Metabolic(dysfunction)-associated fatty liver disease(MAFLD)affects a third of the population and is a leading cause of liver-related death.Since no effective treatments exist,novel approaches to drug development are ...Metabolic(dysfunction)-associated fatty liver disease(MAFLD)affects a third of the population and is a leading cause of liver-related death.Since no effective treatments exist,novel approaches to drug development are required.Unfortunately,outdated terminology and definitions of the disease are hampering efforts to develop new drugs and treatments.An international consensus panel has put forth an influential proposal for the disease to be renamed from nonalcoholic fatty liver disease(NAFLD)to MAFLD,includ-ing a proposal for how the disease should be diagnosed.As allies with the many stakeholders in MAFLD care―including patients,patients’advocates,clinicians,researchers,nurse and allied health groups,regional societies,and others―we are aware of the negative consequences of the NAFLD term and definition.We share the sense of urgency for change and will act in new ways to achieve our goals.Although there is much work to be done to overcome clinical inertia and reverse worrisome recent trends,the MAFLD initiative provides a firm foundation to build on.It provides a roadmap for moving for-ward toward more efficient care and affordable,sustainable drug and device innovation in MAFLD care.We hope it will bring promising new opportunities for a brighter future for MAFLD care and improve care and outcomes for patients of one of the globe’s largest and costliest public health burdens.From this viewpoint,we have revisited this initiative through the perspectives of drug development and regulatory science.展开更多
Population growth, increasing drought, and natural resources degradation are significant global issues.Fortunately, management practices to improve soil health can address many of these issues in ways that are both go...Population growth, increasing drought, and natural resources degradation are significant global issues.Fortunately, management practices to improve soil health can address many of these issues in ways that are both good forthe farmer and the environment. In 2012, the United States Department of Agriculture (USDA) Natural ResourcesConservation Service initiated its“Unlock the Secrets in the Soil” campaign to assist farmers and ranchers with adoptingsoil health systems. Other notable efforts at the federal level include research and education projects by USDAAgricultural Research Service, National Instituite of Food and Agriculture, and Sustainable Agriculture Research andEducation program. The importance of improving soil health is also recognized far beyond federal government programs.The Soil Health Institute, a nonprofit charity, was established to safeguard and enhance the vitality and productivity of soilthrough scientific research and adoption. Crop commodity organizations are promoting soil health, such as the Soil HealthPartnership. The Nature Conservancy is helping companies and private landowners incorporate soil health into theirsustainability efforts. Such efforts are supported by the Foundation for Food and Agriculture Research, as well as by someof the leading global food companies such as General Mills. These are just a few of the many efforts to improve soil healthin the USA. The significance of the expanding global population, natural resource challenges, and responsibilities tocurrent and future generations truly make enhancing soil health a global imperative.展开更多
文摘Metabolic(dysfunction)-associated fatty liver disease(MAFLD)affects a third of the population and is a leading cause of liver-related death.Since no effective treatments exist,novel approaches to drug development are required.Unfortunately,outdated terminology and definitions of the disease are hampering efforts to develop new drugs and treatments.An international consensus panel has put forth an influential proposal for the disease to be renamed from nonalcoholic fatty liver disease(NAFLD)to MAFLD,includ-ing a proposal for how the disease should be diagnosed.As allies with the many stakeholders in MAFLD care―including patients,patients’advocates,clinicians,researchers,nurse and allied health groups,regional societies,and others―we are aware of the negative consequences of the NAFLD term and definition.We share the sense of urgency for change and will act in new ways to achieve our goals.Although there is much work to be done to overcome clinical inertia and reverse worrisome recent trends,the MAFLD initiative provides a firm foundation to build on.It provides a roadmap for moving for-ward toward more efficient care and affordable,sustainable drug and device innovation in MAFLD care.We hope it will bring promising new opportunities for a brighter future for MAFLD care and improve care and outcomes for patients of one of the globe’s largest and costliest public health burdens.From this viewpoint,we have revisited this initiative through the perspectives of drug development and regulatory science.
文摘Population growth, increasing drought, and natural resources degradation are significant global issues.Fortunately, management practices to improve soil health can address many of these issues in ways that are both good forthe farmer and the environment. In 2012, the United States Department of Agriculture (USDA) Natural ResourcesConservation Service initiated its“Unlock the Secrets in the Soil” campaign to assist farmers and ranchers with adoptingsoil health systems. Other notable efforts at the federal level include research and education projects by USDAAgricultural Research Service, National Instituite of Food and Agriculture, and Sustainable Agriculture Research andEducation program. The importance of improving soil health is also recognized far beyond federal government programs.The Soil Health Institute, a nonprofit charity, was established to safeguard and enhance the vitality and productivity of soilthrough scientific research and adoption. Crop commodity organizations are promoting soil health, such as the Soil HealthPartnership. The Nature Conservancy is helping companies and private landowners incorporate soil health into theirsustainability efforts. Such efforts are supported by the Foundation for Food and Agriculture Research, as well as by someof the leading global food companies such as General Mills. These are just a few of the many efforts to improve soil healthin the USA. The significance of the expanding global population, natural resource challenges, and responsibilities tocurrent and future generations truly make enhancing soil health a global imperative.
