The reason why tumors generally have a modest or transient response to antiangiogenic therapy is not well understood. This poses a major challenge for sorafenib treatment of advanced hepatocellular carcinoma(HCC) wher...The reason why tumors generally have a modest or transient response to antiangiogenic therapy is not well understood. This poses a major challenge for sorafenib treatment of advanced hepatocellular carcinoma(HCC) where alternate therapies are lacking. We recently published a paper entitled "Co-option of liver vessels and not sprouting angiogenesis drives acquired sorafenib resistance in hepatocellular carcinoma" in the Journal of the National Cancer Institute, providing a potential explanation for this limited beneit. We found that in mice bearing HCCs that had acquired resistance to sorafenib, tumors had switched from using angiogenesis for growth to co-opting the liver vasculature by becoming more invasive. Accumulating evidence suggests that many human tumor types may use vessel co-option, which has profound implications for the use of anti-angiogenic agents for cancer treatment.展开更多
Advanced hepatocellular carcinoma(HCC)is difficult to treat Sorafenib is a selective inhibitor of vascular endothelial growth factor receptor 2(VEGFR2).HCCs are hypervascular tumors.However,the durability of response ...Advanced hepatocellular carcinoma(HCC)is difficult to treat Sorafenib is a selective inhibitor of vascular endothelial growth factor receptor 2(VEGFR2).HCCs are hypervascular tumors.However,the durability of response to sorafenib is limited.The cover art shows a new explanation for why the anti-tumor effects of sorafenib on HCC may be short-lived and why alternate展开更多
文摘The reason why tumors generally have a modest or transient response to antiangiogenic therapy is not well understood. This poses a major challenge for sorafenib treatment of advanced hepatocellular carcinoma(HCC) where alternate therapies are lacking. We recently published a paper entitled "Co-option of liver vessels and not sprouting angiogenesis drives acquired sorafenib resistance in hepatocellular carcinoma" in the Journal of the National Cancer Institute, providing a potential explanation for this limited beneit. We found that in mice bearing HCCs that had acquired resistance to sorafenib, tumors had switched from using angiogenesis for growth to co-opting the liver vasculature by becoming more invasive. Accumulating evidence suggests that many human tumor types may use vessel co-option, which has profound implications for the use of anti-angiogenic agents for cancer treatment.
文摘Advanced hepatocellular carcinoma(HCC)is difficult to treat Sorafenib is a selective inhibitor of vascular endothelial growth factor receptor 2(VEGFR2).HCCs are hypervascular tumors.However,the durability of response to sorafenib is limited.The cover art shows a new explanation for why the anti-tumor effects of sorafenib on HCC may be short-lived and why alternate
