Background: Despite the growing recognition of the importance of cognitive sym ptoms for the diagnosis and management of atypical parkinsonian syndromes, the c ognitive assessment of the patients in clinical practice ...Background: Despite the growing recognition of the importance of cognitive sym ptoms for the diagnosis and management of atypical parkinsonian syndromes, the c ognitive assessment of the patients in clinical practice often remains very limi ted.Objectives: To examine the ability of a brief and simple cognitive screening test to detect cognitive deficits in atypical parkinsonian syndromes. Methods: Addenbrooke’s cognitive examination (ACE), the mini-mental state examination(M MSE), and the dementia rating scale (DRS) were applied to 26 patients with multi ple system atrophy (MSA), 39 with progressive supranuclear palsy (PSP), and 25 w ith cortico basal degeneration (CBD). The results were then compared with those obtained in 30 healthy age matched volunteers and 30 patients with Alzheimer’s disease. Results: In all four diseases the rate of detection of cognitive impair ment on ACE was higher than on MMSE and comparable with DRS. The severity of cog nitive impairment was most pronounced in the CBD group, which showed a similar d egree of impairment to the Alzheimer group.In contrast, MSA patients were the le ast cognitively impaired.The PSP group took an intermediate position. Conclusion s:Cognitive impairment in atypical parkinsonian syndromes can be detected using a brief and clinically applicable bedside test such as ACE.展开更多
文摘Background: Despite the growing recognition of the importance of cognitive sym ptoms for the diagnosis and management of atypical parkinsonian syndromes, the c ognitive assessment of the patients in clinical practice often remains very limi ted.Objectives: To examine the ability of a brief and simple cognitive screening test to detect cognitive deficits in atypical parkinsonian syndromes. Methods: Addenbrooke’s cognitive examination (ACE), the mini-mental state examination(M MSE), and the dementia rating scale (DRS) were applied to 26 patients with multi ple system atrophy (MSA), 39 with progressive supranuclear palsy (PSP), and 25 w ith cortico basal degeneration (CBD). The results were then compared with those obtained in 30 healthy age matched volunteers and 30 patients with Alzheimer’s disease. Results: In all four diseases the rate of detection of cognitive impair ment on ACE was higher than on MMSE and comparable with DRS. The severity of cog nitive impairment was most pronounced in the CBD group, which showed a similar d egree of impairment to the Alzheimer group.In contrast, MSA patients were the le ast cognitively impaired.The PSP group took an intermediate position. Conclusion s:Cognitive impairment in atypical parkinsonian syndromes can be detected using a brief and clinically applicable bedside test such as ACE.
