Great differences in hazard and losses were shown from two tsunamis, both generated in Chile, one in 1960 and the other in 2010. Numerical simulation was applied to the tsunami analysis. The fault dislocation of the s...Great differences in hazard and losses were shown from two tsunamis, both generated in Chile, one in 1960 and the other in 2010. Numerical simulation was applied to the tsunami analysis. The fault dislocation of the seafioor was assumed to equal to the initial tsunami wave field, which can be calculated by the formula of fault dislocation in the elastic isotropic half-space. The linear long wave theory was used as the tsunami hydrodynamic model, and the finite difference method and leap-frog scheme were selected for solving the equations. The accuracy of the simulated results was verified by the observed data in five tide gauges. By means of two scenario tsunamis, the analytical results show that the earthquake magnitude, bathymetry in rupture zone and rapid release of warning information in 2010 tsunami are the main explanations of the aforementioned great difference.展开更多
Measure is a map from the reality or experimental world to the mathematical world, through which people can more easily understand the properties of entities and the relationship between them. But the traditional soft...Measure is a map from the reality or experimental world to the mathematical world, through which people can more easily understand the properties of entities and the relationship between them. But the traditional software measurement methods have been unable to effectively measure this large-scale software. Therefore, trustworthy measurement gives an accurate measurement to these emerging features, providing valuable perspectives and different research dimensions to understand software systems. The paper introduces the complex network theory to software measurement methods and proposes a statistical measurement methodology. First we study the basic parameters of the complex network, and then introduce two new measurement parameters: structural holes, matching coefficient.展开更多
With the rapid development of the embedded technology, research and implement of the Internet of things will be a new technology revolution, yet the implement of the Internet of things is on the base of the communicat...With the rapid development of the embedded technology, research and implement of the Internet of things will be a new technology revolution, yet the implement of the Internet of things is on the base of the communication between the things. For this reason, realizing the function of communication between singlechip is particularly important. Based on the characteristics of the embedded microcontroller, we analyzed the traditional PC TCP/IP protocol, and appropriately tailored TCP/IP protocol cluster on the basis of the characteristics of embedded singlechip. At last, we realized the reduced TCP/IP protocol cluster suitable for embedded singlechip, on AVR singlechip platform.展开更多
Three-dimensional(3D)cell culture methods have been validated that can replicate the tumor environment in vivo to a large extent,providing an effective tool for studying tumors.In this study,we demonstrated the use of...Three-dimensional(3D)cell culture methods have been validated that can replicate the tumor environment in vivo to a large extent,providing an effective tool for studying tumors.In this study,we demonstrated the use of standard laboratory pipette tips as micro vessels for generating 3D cell spheroids.No microfabrication or wet-chemistry surface modifications were involved in the procedure.Spheroids consisting of single or multiple cell types were generated within 24 h just by pipetting and incubating a cell suspension in pipette tips.Scanning electron microscope and optical microscope proved that the cells grew together tightly,and suggested that while gravity force might have initiated the sedimentation of cells at the bottom of the tip,the active aggregation of cells to form tight cell-cell interactions drove the formation of spheroids.Using common laboratory micropipettes and pipette tips,the rate of spheroid generation and the generation reproducibility was characterized from five boxes each with 80 tips.The ease of transferring reagents allowed modeling of the growth of microvascular endothelial cells in tumor spheroids.Moreover,the pairing and fusion of tumor spheroids could be manipulated in the pipette tips,suggesting the potential for building and assembling heterogeneous micro-tumor tissues in vitro to mimic solid tumors in vivo.This study demonstrated that spheroids can be readily and cost-effectively generated in standard biological laboratories in a timely manner using pipette tips.展开更多
Dear Editor,PD is characterized by the loss of dopaminergic neurons in substantia nigra,and the loss of dopamine resulting in motor deficit.1 Its main pathological hallmarks include the genetic mutations of gene such ...Dear Editor,PD is characterized by the loss of dopaminergic neurons in substantia nigra,and the loss of dopamine resulting in motor deficit.1 Its main pathological hallmarks include the genetic mutations of gene such as a-synudein.2 Increasing study showed that the dopaminergic neurons in midbrain are sensitive and damaged by the PD toxins.展开更多
基金supported by Environmental Protection Research Fund for Public Interest (No.201209040)
文摘Great differences in hazard and losses were shown from two tsunamis, both generated in Chile, one in 1960 and the other in 2010. Numerical simulation was applied to the tsunami analysis. The fault dislocation of the seafioor was assumed to equal to the initial tsunami wave field, which can be calculated by the formula of fault dislocation in the elastic isotropic half-space. The linear long wave theory was used as the tsunami hydrodynamic model, and the finite difference method and leap-frog scheme were selected for solving the equations. The accuracy of the simulated results was verified by the observed data in five tide gauges. By means of two scenario tsunamis, the analytical results show that the earthquake magnitude, bathymetry in rupture zone and rapid release of warning information in 2010 tsunami are the main explanations of the aforementioned great difference.
文摘Measure is a map from the reality or experimental world to the mathematical world, through which people can more easily understand the properties of entities and the relationship between them. But the traditional software measurement methods have been unable to effectively measure this large-scale software. Therefore, trustworthy measurement gives an accurate measurement to these emerging features, providing valuable perspectives and different research dimensions to understand software systems. The paper introduces the complex network theory to software measurement methods and proposes a statistical measurement methodology. First we study the basic parameters of the complex network, and then introduce two new measurement parameters: structural holes, matching coefficient.
文摘With the rapid development of the embedded technology, research and implement of the Internet of things will be a new technology revolution, yet the implement of the Internet of things is on the base of the communication between the things. For this reason, realizing the function of communication between singlechip is particularly important. Based on the characteristics of the embedded microcontroller, we analyzed the traditional PC TCP/IP protocol, and appropriately tailored TCP/IP protocol cluster on the basis of the characteristics of embedded singlechip. At last, we realized the reduced TCP/IP protocol cluster suitable for embedded singlechip, on AVR singlechip platform.
基金supported by the National Key Research and Development Program of China(2021YFD1901205)the National Natural Science Foundation of China(42177022 and 32071595)+3 种基金the Fundamental Research Funds for the Central Universities(2662023PY010)the Spanish Ministry of Science and Innovation(PID2020-115813RA-I00)the Fondo Europeo de Desarrollo Regional(FEDER)the Consejería de Transformación Económica,Industria,Conocimiento y Universidades of the Junta de Andalucía(FEDER Andalucía 2014–2020 Objetivo temático“01-Refuerzo de la investigación,el desarrollo tecnológico y la innovación”)(P20_00879(ANDABIOMA))。
基金supported by the National Natural Science Foundation of China(No.32171401)the Natural Science Foundation of Chongqing(No.CSTB2022NSCQ-MSX0808)the Specific Research Fund of the Innovation Platform for Academicians of Hainan Province(No.YSPTZX202126),China.
文摘Three-dimensional(3D)cell culture methods have been validated that can replicate the tumor environment in vivo to a large extent,providing an effective tool for studying tumors.In this study,we demonstrated the use of standard laboratory pipette tips as micro vessels for generating 3D cell spheroids.No microfabrication or wet-chemistry surface modifications were involved in the procedure.Spheroids consisting of single or multiple cell types were generated within 24 h just by pipetting and incubating a cell suspension in pipette tips.Scanning electron microscope and optical microscope proved that the cells grew together tightly,and suggested that while gravity force might have initiated the sedimentation of cells at the bottom of the tip,the active aggregation of cells to form tight cell-cell interactions drove the formation of spheroids.Using common laboratory micropipettes and pipette tips,the rate of spheroid generation and the generation reproducibility was characterized from five boxes each with 80 tips.The ease of transferring reagents allowed modeling of the growth of microvascular endothelial cells in tumor spheroids.Moreover,the pairing and fusion of tumor spheroids could be manipulated in the pipette tips,suggesting the potential for building and assembling heterogeneous micro-tumor tissues in vitro to mimic solid tumors in vivo.This study demonstrated that spheroids can be readily and cost-effectively generated in standard biological laboratories in a timely manner using pipette tips.
基金supported by the National Natural Science Foundation of China(no.81903829 and 81801398)the grant jointly funded by National Natural Science Foundation of China and the Macao Science and Technology Development Fund(no.0036/2018/AFJ)+1 种基金the Science and Technology Planning Project of Sichuan Province,China(no.2018JY0474,2019JDPT0010,2019YFSY0014,SYZ202076,2020YJ0494,and 2020086)Joint project of Luzhou Municipal People's Government and Southwest Medical University,China(no.2018LZXNYD-YL05,2019LZXNYDJ02,2018LZXNYD-ZK41,2018LZXNYD-ZK42,and 2019LZXNYDJ05).
文摘Dear Editor,PD is characterized by the loss of dopaminergic neurons in substantia nigra,and the loss of dopamine resulting in motor deficit.1 Its main pathological hallmarks include the genetic mutations of gene such as a-synudein.2 Increasing study showed that the dopaminergic neurons in midbrain are sensitive and damaged by the PD toxins.
