The multiple filamentation of terawatt femtosecond （fs） laser pulses is experimentally studied in a natural environment. A more than 30-m long plasma filament with a millimeter diameter is formed by the collimated f...The multiple filamentation of terawatt femtosecond （fs） laser pulses is experimentally studied in a natural environment. A more than 30-m long plasma filament with a millimeter diameter is formed by the collimated fs laser pulse freely propagating in an open atmosphere. This study provides the first quantitative experimental data about the electron density of a long range light filament in the atmosphere. The electron density of such a filament is quantitatively detected by using an electric method, showing that it is at the 1011-cm -3 level.展开更多
Objective:To study the anti-hypertrophic scar effect of the six-herb Chinese medicine composition(SCMC) ointment on the rabbit ear hypertrophic scar models.Methods:The optimal formulation of SCMC ointment matrix was s...Objective:To study the anti-hypertrophic scar effect of the six-herb Chinese medicine composition(SCMC) ointment on the rabbit ear hypertrophic scar models.Methods:The optimal formulation of SCMC ointment matrix was screened by the orthogonal designs and a series of evaluation tests.The SCMC ointment was prepared through emulsifying method.The rabbit ear hypertrophic scar models were established and used to investigate the anti-hypertrophic scar effect of SCMC ointment.Results:Our results demonstrated that all the quality control indications of the SCMC ointment met the requirements.Anti-hypertrophic scar activity results showed that all the rabbit ear scar tissues appeared different degrees of shrink and fading,and took an unobvious but palpable shift from hard to soft texture with the low,middle and high concentration SCMC ointments treatments in vivo.Additionally,on 21 st day the scar area and thickness in different concentrations of SCMC ointment groups were significantly reduced than control group,in a concentration-dependent manner.The immunohistochemical results also indicated that the SCMC ointment had good anti-hypertrophic scar properties and could inhibit hypertrophic scar formation.Conclusion:The SCMC ointment could improve the blood circulation condition of hypertrophic scar tissues.Our research has demonstrated the Chinese medicine composition ointment with good antihypertrophic scar properties that could be used to treat hypertrophic scars.Meanwhile,it provides a theoretical basis for further clinical application.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11574387,11404335,11474002,and 11535001)the National Basic Research Program of China(Grant Nos.2013CBA01501 and 2013CB922401)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grants Nos.XDB16010200 and XDB07030300)the Science Challenge Project,China(Grant No.TZ2016005)
文摘The multiple filamentation of terawatt femtosecond （fs） laser pulses is experimentally studied in a natural environment. A more than 30-m long plasma filament with a millimeter diameter is formed by the collimated fs laser pulse freely propagating in an open atmosphere. This study provides the first quantitative experimental data about the electron density of a long range light filament in the atmosphere. The electron density of such a filament is quantitatively detected by using an electric method, showing that it is at the 1011-cm -3 level.
基金supported by grants from Academic Talent Project of Guizhou Provincial Department of Science and Technology (Qiankehe Platform Talent[2017]5735-28)the Doctorial Startup Foundation of Guizhou University of Traditional Chinese Medicine (2016-3043-043160011)+5 种基金Guizhou discipline construction project (GNYL[2017]008)the National Key Research and Development Program of China (2018YFC1708100)University Students Chinese Medicine Preparation Innovation and Entrepreneurship Studio (Qiangaojiaofa[2017]158)Program for University Students Innovation and Entrepreneurship Plan of Guizhou University of Traditional Chinese Medicine (GZY Dachuanghe (2018) 30)Guizhou Province Top Major Chinese Medicine (Qianjiaogaofa[2017]158)Guizhou High-Level Innovative Talents Training Program (Qiankehe[2015]4032)。
文摘Objective:To study the anti-hypertrophic scar effect of the six-herb Chinese medicine composition(SCMC) ointment on the rabbit ear hypertrophic scar models.Methods:The optimal formulation of SCMC ointment matrix was screened by the orthogonal designs and a series of evaluation tests.The SCMC ointment was prepared through emulsifying method.The rabbit ear hypertrophic scar models were established and used to investigate the anti-hypertrophic scar effect of SCMC ointment.Results:Our results demonstrated that all the quality control indications of the SCMC ointment met the requirements.Anti-hypertrophic scar activity results showed that all the rabbit ear scar tissues appeared different degrees of shrink and fading,and took an unobvious but palpable shift from hard to soft texture with the low,middle and high concentration SCMC ointments treatments in vivo.Additionally,on 21 st day the scar area and thickness in different concentrations of SCMC ointment groups were significantly reduced than control group,in a concentration-dependent manner.The immunohistochemical results also indicated that the SCMC ointment had good anti-hypertrophic scar properties and could inhibit hypertrophic scar formation.Conclusion:The SCMC ointment could improve the blood circulation condition of hypertrophic scar tissues.Our research has demonstrated the Chinese medicine composition ointment with good antihypertrophic scar properties that could be used to treat hypertrophic scars.Meanwhile,it provides a theoretical basis for further clinical application.
