Sequential nonlinear tracking filter without requirement of measurement decorrelation

Sequential measurement processing is of benefit to both estimation accuracy and computational efficiency. When the noises are correlated across the measurement components, decorrelation based on covariance matrix factorization is required in the previous methods in order to perform sequential updates properly. A new sequential processing method, which carries out the sequential updates directly using the correlated measurement components, is proposed. And a typical sequential processing example is investigated, where the converted position measure- ments are used to estimate target states by standard Kalman filtering equations and the converted Doppler measurements are then incorporated into a minimum mean squared error （MMSE） estimator with the updated cross-covariance involved to account for the correlated errors. Numerical simulations demonstrate the superiority of the proposed new sequential processing in terms of better accuracy and consistency than the conventional sequential filter based on measurement decorrelation.

基于网络药理学和分子对接探讨陈皮治疗阿尔茨海默病的作用机制

本研究通过网络药理学和分子对接阐明陈皮(Citri Reticulatae Pericarpium,CRP)治疗阿尔茨海默病(Alzheimer’s disease,AD)的作用机制。首先,在陈皮中筛选出98个有靶点的化合物和628个相关成分靶点,在疾病数据库中检索得到2483个AD靶点。随后,构建CRP-AD交叠靶点图和蛋白互作(PPI)网络图,对PPI网络图进行拓扑属性分析得到66个与CRP治疗AD密切相关的靶点,对66个靶点进行GO功能和KEGG通路富集分析,靶点在多条生物途径富集,包括松弛素信号通路、钙信号通路、HIF-1信号通路和IL-17信号通路。最后,对靶点和CRP活性成分进行分子对接验证,CRP的活性成分(黄烷酮、橘皮素、黄酮醇、香芹酚、紫苏醛)与靶点通过氢键连接,结合能小于0 kg/mol。本研究采用网络药理学和分子对接的方法系统的揭示了陈皮治疗阿尔茨海默病的作用机制,为以后科研以及临床研究提供理论依据。

基于转录组学技术研究泽泻汤对高脂血症大鼠的降脂作用机制

高脂血症是一种脂质代谢紊乱,其特征是血液循环中脂质水平升高。高脂血症一直与心血管事件和代谢综合征相关疾病的发展有关。泽泻汤(ARD)是著名的中药处方,长期以来被用于治疗眩晕症,这是高脂血症患者的一种症状。在本研究中,我们旨在转录水平上研究ARD对高脂血症大鼠的降脂活性和潜在分子机制。同时应用RNA测序和转录组分析,包括差异表达基因(DEGs)分析、GO功能和KEGG通路分析。结果表明,与CON组相比,HFD组中识别出1981个DEGs(上调1370个,下调611个)。与HFD组相比,ARD组检测到474个DEGs(350个上调和124个下调)。此外,GO分析表明DEGs主要参与以下功能:发育过程、对外部刺激的反应、离子迁移、酒精结合和质膜部分。路径分析表明,这些DEGs显著存在于在胆汁分泌、疟疾、细胞粘附分子、视黄醇代谢、鞘脂信号传导途径、化学致癌作用和T细胞受体信号传导途径。研究表明ARD通过多种机制减轻了高脂血症引起的脂质代谢紊乱,这为ARD的进一步药理研究提供了重要的科学依据。