Bone engineering scaffolds with antibacterial activity satisfy the repair of bacterial infected bone defects,which is an expected issue in clinical.In this work,3D-printed polymer-derived forsterite scaffolds were pro...Bone engineering scaffolds with antibacterial activity satisfy the repair of bacterial infected bone defects,which is an expected issue in clinical.In this work,3D-printed polymer-derived forsterite scaffolds were proposed to be deposited with hydroxyapatite(HA)coating via a hydrothermal treatment,achieving the functions of photothermal-induced antibacterial ability and bioactivity.The results showed that polymer-derived forsterite scaffolds possessed the photothermal antibacterial ability to inhibit Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli)in vitro,owing to the photothermal effect of free carbon embedded in the scaffolds.The morphology of HA coating on forsterite scaffolds could be controlled through changing the hydrothermal temperature and the pH value of the reaction solution during hydrothermal treatment.Furthermore,HA coating did not influence the mechanical strength and photothermal effect of the scaffolds,but facilitated the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells(rBMSCs)on scaffolds.Hence,the HA-deposited forsterite scaffolds would be greatly promising for repairing bacterial infected bone defects.展开更多
基金supported by the National Natural Science Foundation of China(Nos.51872185,51972212,and 52072246)Shanghai Natural Science Foundation(No.19ZR1435100).
文摘Bone engineering scaffolds with antibacterial activity satisfy the repair of bacterial infected bone defects,which is an expected issue in clinical.In this work,3D-printed polymer-derived forsterite scaffolds were proposed to be deposited with hydroxyapatite(HA)coating via a hydrothermal treatment,achieving the functions of photothermal-induced antibacterial ability and bioactivity.The results showed that polymer-derived forsterite scaffolds possessed the photothermal antibacterial ability to inhibit Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli)in vitro,owing to the photothermal effect of free carbon embedded in the scaffolds.The morphology of HA coating on forsterite scaffolds could be controlled through changing the hydrothermal temperature and the pH value of the reaction solution during hydrothermal treatment.Furthermore,HA coating did not influence the mechanical strength and photothermal effect of the scaffolds,but facilitated the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells(rBMSCs)on scaffolds.Hence,the HA-deposited forsterite scaffolds would be greatly promising for repairing bacterial infected bone defects.
