The rapidly self-renewing epithelium in the mammalian intestine is maintained by multipotent intestinal stem cells(ISCs) located at the bottom of the intestinal crypt that are interspersed with Paneth cells in the sma...The rapidly self-renewing epithelium in the mammalian intestine is maintained by multipotent intestinal stem cells(ISCs) located at the bottom of the intestinal crypt that are interspersed with Paneth cells in the small intestine andPaneth-like cells in the colon. The ISC compartment is also closely associated with a sub-epithelial compartmentthat contains multiple types of mesenchymal stromal cells. With the advances in single cell and gene editingtechnologies, rapid progress has been made for the identification and characterization of the cellular componentsof the niche microenvironment that is essential for self-renewal and differentiation of ISCs. It has becomeincreasingly clear that a heterogeneous population of mesenchymal cells as well as the Paneth cells collectivelyprovide multiple secreted niche signals to promote ISC self-renewal. Here we review and summarize recentadvances in the regulation of ISCs with a main focus on the definition of niche cells that sustain ISCs.展开更多
Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stemcells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent study re...Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stemcells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent study reported thediscovery of a new population of stromal cells in mice termed MAP3K2-Regulated Intestinal Stromal Cells (MRISCs);these cells reside at the base of colonic crypt and function to protect colonic stem cells during colonicinflammation by expressing the Wnt agonist R-spondin1 (Rspo1).展开更多
基金The research in the Xi’s lab is in part supported by the National Key Research and Development Program of China(2017YFA0103602)GZ is supported by grants from National Natural Science Foundation for Young Scientists of China(31801229)+1 种基金China Postdoctoral Science Foundation(2017 M610779)Beijing Postdoctoral Research Foundation(2016-ZZ-110).
文摘The rapidly self-renewing epithelium in the mammalian intestine is maintained by multipotent intestinal stem cells(ISCs) located at the bottom of the intestinal crypt that are interspersed with Paneth cells in the small intestine andPaneth-like cells in the colon. The ISC compartment is also closely associated with a sub-epithelial compartmentthat contains multiple types of mesenchymal stromal cells. With the advances in single cell and gene editingtechnologies, rapid progress has been made for the identification and characterization of the cellular componentsof the niche microenvironment that is essential for self-renewal and differentiation of ISCs. It has becomeincreasingly clear that a heterogeneous population of mesenchymal cells as well as the Paneth cells collectivelyprovide multiple secreted niche signals to promote ISC self-renewal. Here we review and summarize recentadvances in the regulation of ISCs with a main focus on the definition of niche cells that sustain ISCs.
基金This work was supported by National Natural Science Foundation for Young Scientists of China(31801229 to G.Z.)by National Key Research and Development Program of China(2017YFA0103602 and 2020YFA0800152)from the Chinese Ministry of Science and Technology.
文摘Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stemcells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent study reported thediscovery of a new population of stromal cells in mice termed MAP3K2-Regulated Intestinal Stromal Cells (MRISCs);these cells reside at the base of colonic crypt and function to protect colonic stem cells during colonicinflammation by expressing the Wnt agonist R-spondin1 (Rspo1).
