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Testosterone replacement maintains smooth muscle content in the corpus cavernosum of orchiectomized rats 被引量:1
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作者 Graziele Halmenschlager Ernani Luis Rhoden +4 位作者 Gabriela Almeida Motta Lucas Sagrillo Fagundes Jorge Luiz Medeiros Jr rosalva meurer Claudia Ramos Rhoden 《Asian Journal of Urology》 2017年第4期223-229,共7页
Objective:To evaluate the effects of testosterone(T)on the maintenance of corpus cavernosum(CC)structure and apoptosis.Methods:Animals were divided into three groups:sham operation group(n Z 8)underwent sham operation... Objective:To evaluate the effects of testosterone(T)on the maintenance of corpus cavernosum(CC)structure and apoptosis.Methods:Animals were divided into three groups:sham operation group(n Z 8)underwent sham operation;Orchiectomized(Orchiec)t oily vehicle group(n Z 8)underwent bilateral orchiectomy and received a single dose of oily vehicle by intramuscular injection(i.m.)30 days after orchiectomy;and Orchiec t T group(n Z 8)underwent bilateral orchiectomy and received a single dose of T undecanoate 100 mg/kg i.m.30 days after the surgery.Animals were euthanized 60 days after the beginning of the experiment with an anesthetic overdose of ketamine and xylazine.Blood samples and penile tissue were collected on euthanasia. 展开更多
关键词 Testosterone replacement HISTOMORPHOMETRY Androgen deprivation HYPOGONADISM Corpus cavernosum
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