Pancreatic ductal adenocarcinoma(PDAC)is a major cause of cancer-related death worldwide.Despite recent advances in treatment options,prognosis remains poor,and data estimates from the United States(US)show that PDAC ...Pancreatic ductal adenocarcinoma(PDAC)is a major cause of cancer-related death worldwide.Despite recent advances in treatment options,prognosis remains poor,and data estimates from the United States(US)show that PDAC will surpass colorectal cancer to become the second most common cause of cancer-related death by 2040(1).Surgery followed by adjuvant chemotherapy is the only potentially curative treatment option for patients with PDAC;however,the majority present with advanced stage,non-resectable disease.Early diagnosis could improve the dismal prognosis for this patient group,but this remains challenging due to numerous factors including a lack of approved biomarkers and screening programmes,and non-specificity or late presentation of symptoms.展开更多
文摘Pancreatic ductal adenocarcinoma(PDAC)is a major cause of cancer-related death worldwide.Despite recent advances in treatment options,prognosis remains poor,and data estimates from the United States(US)show that PDAC will surpass colorectal cancer to become the second most common cause of cancer-related death by 2040(1).Surgery followed by adjuvant chemotherapy is the only potentially curative treatment option for patients with PDAC;however,the majority present with advanced stage,non-resectable disease.Early diagnosis could improve the dismal prognosis for this patient group,but this remains challenging due to numerous factors including a lack of approved biomarkers and screening programmes,and non-specificity or late presentation of symptoms.
