Dear Editor,Kindlin-1 plays a major role in the activation of integrins[1].Kindlin-1 is often overexpressed in cancers.Kindlin-1 overexpression has been associated with a higher propensity of breast cancer patients t...Dear Editor,Kindlin-1 plays a major role in the activation of integrins[1].Kindlin-1 is often overexpressed in cancers.Kindlin-1 overexpression has been associated with a higher propensity of breast cancer patients to metastasize to the lungs[2,3].Furthermore,Kindlin-1 depletion in mouse models was found to inhibit tumor growth and lung metastasis[3,4].However,the underlying mechanisms remain poorly explored.展开更多
基金All mouse experiments were performed by competent researchers in accredited facilities(license B75-05-18 and B75-05-17 given by the National Authority)and following the French and European regulation in force on the protection of animals used for scientific purposes and to the Institut Curie recommendation on animal care,including 3R principle.
文摘Dear Editor,Kindlin-1 plays a major role in the activation of integrins[1].Kindlin-1 is often overexpressed in cancers.Kindlin-1 overexpression has been associated with a higher propensity of breast cancer patients to metastasize to the lungs[2,3].Furthermore,Kindlin-1 depletion in mouse models was found to inhibit tumor growth and lung metastasis[3,4].However,the underlying mechanisms remain poorly explored.
