期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Association of bilirubin and protein thiols in relation to copper and ceruloplasmin in hyperbilirubinemic patients
1
作者 Mungli Prakash Jeevan K Shetty +2 位作者 roshan d' souza Suhasa Upadhya Vijay Kumar 《海南医学院学报》 CAS 2009年第1期40-44,共5页
Objective:Bilirubin is a double edged sword in biological system,acting as a toxic molecule and cytoprotectant.Unconjugated bilirubin is proved to show antioxidant activity in vitro and in vivo.In the current work we ... Objective:Bilirubin is a double edged sword in biological system,acting as a toxic molecule and cytoprotectant.Unconjugated bilirubin is proved to show antioxidant activity in vitro and in vivo.In the current work we tried to know the relationship between both conjugated and unconjugated bilirubin with copper and protein thiols in patients with hyperbilirubinemia.Methods:Study was conducted on 56 hyperbilirubinemic cases and 56 healthy controls.Serum copper,ceruloplasmin,protein thiols,total bilirubin,conjugated and unconjugated bilirubin,unconjugated bilirubin/albumin ratio,total protein,albumin,AST,ALT and ALP were estimated.Results:There was significant increase in serum copper,total bilirubin,conjugated and unconjugated bilirubin,unconjugated bilirubin/albumin ratio,AST,ALT,and ALP,and decrease in serum ceruloplasmin,protein thiols,total protein,and albumin in hyperbilirubinemic cases when compared to healthy controls.Conjugated bilirubin correlated positively with liver enzymes AST and ALP,and negatively with protein thiols,total protein and albumin.Unconjugated bilirubin correlated positively with ALT.Protein thiols correlated negatively with copper and positively with ceruloplasmin,and also correlated negatively with liver enzymes like AST,ALT and ALP,and positively with total protein and albumin.Conclusion:Combination of elevated levels of trace elements like copper and availability of reducing agent like bilirubin may prove deleterious by generating free radicals. 展开更多
关键词 蛋白质 硫藤黄菌素 血浆铜蓝蛋白 抗氧添加剂
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部