Cancer is a serious threat to human health.Fungal polysaccharide is a polar biological macromolecule with low toxicity.It has a wide range of biological activities,including immune regulation,antitumor activity,and an...Cancer is a serious threat to human health.Fungal polysaccharide is a polar biological macromolecule with low toxicity.It has a wide range of biological activities,including immune regulation,antitumor activity,and antiviral activity.In recent years,the research results have shown that polysaccharides from fungus in traditional Chinese medicine have excellent antitumor effect in liver cancer,gastric cancer,breast cancer,colon cancer,esophageal cancer,and lung cancer.Therefore,the research and development of fungal polysaccharides are of great significance for the development of antitumor drugs in the future.展开更多
Background and aim:There are still no clinically satisfactory therapy for PBC.This study was performed to assess the safety and efficacy of IAs for the therapy of PBC.Methods:Relevant studies were identified and selec...Background and aim:There are still no clinically satisfactory therapy for PBC.This study was performed to assess the safety and efficacy of IAs for the therapy of PBC.Methods:Relevant studies were identified and selected by searching PubMed,Web of Science and Cochrane Library databases.The primary outcome was defined as the need for mortality or liver transplantation.Adverse effects and liver biochemical variables were a secondary outcome.Results:Nine randomized controlled trials,involving six different treatment regimens with a total of 996 patients,were included in the analysis.On meta-analysis,IAs was not associated with a reduction in risk of mortality or liver transplantation(risk ratio[RR]:0.92,95% confidence interval[CI]:0.69-1.22,P=0.57,P=0%),and have resulted in more adverse effects(RR:1.44,95%CI:1.08-1.92,P=0.01,P=19%).Subgroup analysis showed that IAs monotherapy caused adverse effects such as diarrthea,abdominal pain,and renal insufficiency(RR:1.36,95% CI:1.01-1.82,P=0.04,P=48%).IAs therapy did not prominently improve markers of liver function except for alkaline phosphatases(weighted mean difference[WMD]:-0.38,95% CI:-0.62 to-0.14,P=0.002).Conclusions:IAs cannot reduce the risk of mortality or liver transplantation,whether in IAs monotherapy or combination therapy,and even be associated with more adverse effects.展开更多
The fluctuation law of magnetic fluid seal interface of an agricultural centrifugal pump is theoretically unknown;the pressure and velocity fluctuations are crucial factors that cause interface fluctuation.In this stu...The fluctuation law of magnetic fluid seal interface of an agricultural centrifugal pump is theoretically unknown;the pressure and velocity fluctuations are crucial factors that cause interface fluctuation.In this study,the pressure and velocity fluctuations of the sealing interface on an agricultural centrifugal pump during cavitation were investigated based on the methods of Ansys CFX numerical calculation and experimental verification.The results demonstrated that at the same flow rate,the pressure fluctuation amplitude of the sealing interface decreased gradually from the shaft surface to the bottom of the polar tooth.At different flow rates,the amplitude of the pressure fluctuation decreased with an increase in the flow rate.The cavitation of the medium aggravated the impact and water hammer of the liquid,leading to the occurrence of the jitter phenomenon in the sealing interface to accelerate the fluctuation frequency of the axial velocity of the sealing liquid,which accelerated the emulsification of the magnetic fluid.This law can provide a reference for the design of magnetic fluid sealing devices for agricultural centrifugal pumps.展开更多
文摘Cancer is a serious threat to human health.Fungal polysaccharide is a polar biological macromolecule with low toxicity.It has a wide range of biological activities,including immune regulation,antitumor activity,and antiviral activity.In recent years,the research results have shown that polysaccharides from fungus in traditional Chinese medicine have excellent antitumor effect in liver cancer,gastric cancer,breast cancer,colon cancer,esophageal cancer,and lung cancer.Therefore,the research and development of fungal polysaccharides are of great significance for the development of antitumor drugs in the future.
文摘Background and aim:There are still no clinically satisfactory therapy for PBC.This study was performed to assess the safety and efficacy of IAs for the therapy of PBC.Methods:Relevant studies were identified and selected by searching PubMed,Web of Science and Cochrane Library databases.The primary outcome was defined as the need for mortality or liver transplantation.Adverse effects and liver biochemical variables were a secondary outcome.Results:Nine randomized controlled trials,involving six different treatment regimens with a total of 996 patients,were included in the analysis.On meta-analysis,IAs was not associated with a reduction in risk of mortality or liver transplantation(risk ratio[RR]:0.92,95% confidence interval[CI]:0.69-1.22,P=0.57,P=0%),and have resulted in more adverse effects(RR:1.44,95%CI:1.08-1.92,P=0.01,P=19%).Subgroup analysis showed that IAs monotherapy caused adverse effects such as diarrthea,abdominal pain,and renal insufficiency(RR:1.36,95% CI:1.01-1.82,P=0.04,P=48%).IAs therapy did not prominently improve markers of liver function except for alkaline phosphatases(weighted mean difference[WMD]:-0.38,95% CI:-0.62 to-0.14,P=0.002).Conclusions:IAs cannot reduce the risk of mortality or liver transplantation,whether in IAs monotherapy or combination therapy,and even be associated with more adverse effects.
基金support of the National Natural Science Foundation of China(Grant No.52079118)the Science and Technology Department of Sichuan Province(Grant No.2020YFH0135)+2 种基金the Open Research Subject of Key Laboratory of Fluid and Power Machinery(Xihua University)Ministry of Education(Grant No.LTDL2021-005)Project of Science and Technology Department of Sichuan Province,(Grant No.202573).
文摘The fluctuation law of magnetic fluid seal interface of an agricultural centrifugal pump is theoretically unknown;the pressure and velocity fluctuations are crucial factors that cause interface fluctuation.In this study,the pressure and velocity fluctuations of the sealing interface on an agricultural centrifugal pump during cavitation were investigated based on the methods of Ansys CFX numerical calculation and experimental verification.The results demonstrated that at the same flow rate,the pressure fluctuation amplitude of the sealing interface decreased gradually from the shaft surface to the bottom of the polar tooth.At different flow rates,the amplitude of the pressure fluctuation decreased with an increase in the flow rate.The cavitation of the medium aggravated the impact and water hammer of the liquid,leading to the occurrence of the jitter phenomenon in the sealing interface to accelerate the fluctuation frequency of the axial velocity of the sealing liquid,which accelerated the emulsification of the magnetic fluid.This law can provide a reference for the design of magnetic fluid sealing devices for agricultural centrifugal pumps.
