Background:Patients with hyperplastic polyposis coli syndrome(HPCS)have a propensity to develop colorectal carcinoma(CRC).Patients and Methods:Details were retrieved from the files of patients attending our hospital b...Background:Patients with hyperplastic polyposis coli syndrome(HPCS)have a propensity to develop colorectal carcinoma(CRC).Patients and Methods:Details were retrieved from the files of patients attending our hospital between 1988 and 2004 who fulfilled the World Health Organization criteria for HPCS.Results:Over a period of 16 years,10 cases of HPCS were identified at our hospital(0.625 cases/year or one case every 1.6 years).A mean of 40.3 hyperplastic polyps per patient were found(range 6-159).Other colorectal lesions were found as follows:two patients each had one mixed polyp;there were 15 serrated adenomas in eight patients;and there were 30 tubular,tubulovillous,or villous adenomas in eight patients.Among the 10 patients with HPCS,seven developed a CRC.Of the four villous adenomas,three were associated with a CRC,but only one of the 15 serrated adenomas was associated with a CRC.The pathway of cancer evolution in HPCS patients remains unresolved.Conclusions:Similarly to our results,a review of the literature indicates a high incidence of CRCs in HPCS patients.These patients are at a high risk of developing a CRC and should therefore receive regular colonoscopic surveillance.展开更多
文摘Background:Patients with hyperplastic polyposis coli syndrome(HPCS)have a propensity to develop colorectal carcinoma(CRC).Patients and Methods:Details were retrieved from the files of patients attending our hospital between 1988 and 2004 who fulfilled the World Health Organization criteria for HPCS.Results:Over a period of 16 years,10 cases of HPCS were identified at our hospital(0.625 cases/year or one case every 1.6 years).A mean of 40.3 hyperplastic polyps per patient were found(range 6-159).Other colorectal lesions were found as follows:two patients each had one mixed polyp;there were 15 serrated adenomas in eight patients;and there were 30 tubular,tubulovillous,or villous adenomas in eight patients.Among the 10 patients with HPCS,seven developed a CRC.Of the four villous adenomas,three were associated with a CRC,but only one of the 15 serrated adenomas was associated with a CRC.The pathway of cancer evolution in HPCS patients remains unresolved.Conclusions:Similarly to our results,a review of the literature indicates a high incidence of CRCs in HPCS patients.These patients are at a high risk of developing a CRC and should therefore receive regular colonoscopic surveillance.
