Diet and physical activity influence the composition of gut microbiota,benefit on Alzheimer's disease

Alzheimer's disease is a neurodegenerative disease with complex etiology.Gut microbiota influences the gutbrain axis,which may affect pathways related to the pathogenesis of Alzheimer's disease.Additionally,diet and physical activity are likely to affect the pathology of Alzheimer's disease as well as the gut microbiota.This demonstrates that it may be possible to prevent or halt the progression of Alzheimer's disease by regulating the gut microbiota using diet and physical activity strategies.Therefore,the present study reviews the association between these two interventions and gut microbiota in the human body.It also summarizes how these two interventions benefit Alzheimer's disease.Furthermore,the primary limitations of these two interventions are discussed and promising strategies are proposed,which may be beneficial to further study and develop the intervening measure for the progression of Alzheimer's disease.

多层螺旋CT增强对卵巢交界性浆液性及黏液性肿瘤的诊断价值

目的以病理诊断为依据,评估多层螺旋CT(multi⁃slice spiral CT,MSCT)增强扫描诊断卵巢交界性浆液性肿瘤(serous borderline ovarian tumor,S⁃BOT)和交界性黏液性肿瘤(mucinous borderline ovari⁃an tumor,M⁃BOT)的价值。方法回顾性分析我院经手术病理证实的39例S⁃BOT和46例M⁃BOT患者的术前影像、临床及病理资料,分析并比较肿瘤的MSCT表现。结果以病理结果为金标准,MSCT增强扫描诊断卵巢S⁃BOT和M⁃BOT的灵敏度为87.2%、特异度为89.1%、准确度为88.2%,Kappa值为0.763。S⁃BOT与M⁃BOT在分房、囊液均质、囊壁/间隔增厚、肿块最大经、肿块实性成分平扫CT值及强化率等方面差异有统计学意义(P<0.05)。S⁃BOT单/双房多见,M⁃BOT多房多见;S⁃BOT较M⁃BOT囊液密度更均质;M⁃BOT较S⁃BOT的囊壁/间隔增厚多见;S⁃BOT最大径小于M⁃BOT;S⁃BOT实性成分平扫CT值低于M⁃BOT;二者增强扫描均表现为渐进性延迟强化,S⁃BOT各期强化率均高于M⁃BOT。出血及钙化在两组间差异无统计学意义(P>0.05)。多因素logistic回归显示分房、囊壁/间隔增厚及肿块实性成分平扫CT值在鉴别S⁃BOT及M⁃BOT中具有独立预测价值。结论MSCT增强扫描对卵巢S⁃BOT和M⁃BOT的诊断与病理诊断的一致性较好,其或可作为卵巢S⁃BOT与M⁃BOT的鉴别诊断的有效手段。

肥胖少年的臂-踝脉搏波速度与心血管疾病危险因素的关系探讨

目的探讨肥胖少年的臂-踝脉搏波速度(brachial-ankle pulse wave velocity,BaPWV),与诱发心血管疾病发生的血生化指标的相关性。方法在北京市海淀区选取165例14~17岁的肥胖少年,男90例,女75例,测量体重、身高、血压后,计算BMI,采用动脉硬化检测仪测量臂-踝脉搏波速度(BaPWV),同时检测空腹血生化指标。分析BaPWV与肥胖相关指标,以及心血管疾病危险因素中血生化指标的关系。结果过度肥胖组的BaPWV,与总胆固醇(total cholesterol,TC)、低密度胆固醇(low density lipoprotein cholesterol,LDL-C)、三酰甘油(triglyceride,TG)呈正相关关系;与体重、体质指数(body mass index,BMI)、收缩压呈正相关关系。按照BaPWV测量值分组,BaPWV增高组(高于正常范围,>P_(95))的BaPWV,与总胆固醇(TC)、低密度胆固醇(LDL-C)呈正相关关系;与年龄、体重、体重指数(BMI)呈正相关关系。BaPWV增高与暴露于过度肥胖(BMI>P_(50))之间关联强度的比值比OR=2.159,OR的95%可信区间为1.011~4.613。说明过度肥胖会使BaPWV高于正常范围(>P_(95))的危险度增加2.159倍。结论总胆固醇(TC)和低密度胆固醇(LDL-C),与过度肥胖(BMI>P_(50)),以及BaPWV高于正常范围(>P_(95))有正相关性。过度肥胖会使BaPWV高于正常范围(>P_(95))的危险度增加。

二孩时代孕产妇对育婴知识的知晓及需求情况的调查分析

目的了解孕产妇对育婴知识的知晓情况、影响因素及需求情况,为教学工作、健康宣教及育婴师培训提供依据。方法利用自行设计调查问卷调查随机抽取1072名孕产妇,获取其对婴幼儿日常生活护理、预防接种与常见疾病识别及护理等知识的知晓与需求情况,多因素Logistic回归分析影响知晓率的影响因素。结果1072名孕产妇对育婴知识的总知晓率为61.77%,仅11.94%人能正确回答所有问题。“知晓”组612人,“不足”组460人。多因素Logistic回归分析表明,不同胎次(3胎及以上OR=6.44、2胎OR=2.023)和接受过知识宣传(OR=3.351)是知晓率的影响因素。两组人群获取育婴知识的需求途径主要为医护人员(医院)和知识讲座。结论孕产妇对育婴知识的知晓度不高,倾向于通过医护人员(医院)和知识讲座获取。教学应结合孕产妇对育婴知识的知晓与需求的情况,并运用到实际工作。

城镇空间紧凑度对碳排放的影响研究--以长兴县为例

“双碳”目标为城市发展提供了新方向。紧凑布局是大城市控碳减排的主要策略,这一策略对于县域城镇空间是否适用还需进一步探讨。本研究以浙江省长兴县为例,构建紧凑度综合评价体系,采用熵值法测度2009—2018年的城镇空间紧凑度,判断紧凑度对碳排放是否存在独立作用,并基于测度结果分析了紧凑度对碳排放的影响。结果表明:城镇空间紧凑度与碳排放量均呈现增速逐年放缓的增长态势。在控制变量的情况下,紧凑度对碳排放存在正向作用。经济紧凑度、土地利用紧凑度、基础设施紧凑度的增加使碳排放增加,人口紧凑度、经济紧凑度、基础设施紧凑度和生态环境协同度增加会降低碳排放强度。由于长兴县处于快速城镇化阶段,经济发展以碳排放作为支撑,城镇空间紧凑度促进碳排放,但碳排放强度呈下降趋势,碳排放的经济效益增加,紧凑发展同样适用于县域城镇空间。基于以上结论,本研究提出长兴县城镇空间的紧凑规划策略,为其他县级城市的低碳建设提供借鉴。

《儿科护理学》课程“知识-能力-实践”教学模式探索

在新时代“以就业和需求为导向,以专业建设为宗旨,产教科深度融合”的职业教育理念的指导下,以《儿科护理学》课程教学为切入点,剖析传统课程教学中师资力量短缺薄弱、教学方式单一枯燥和考评方式因循守旧等问题,分析儿科护理教学的专业需求性和社会需求性,并主要从构建教学新模式、变革教学新方法、调整教学新内容、引进教学新技术和完善考评新制度五个方面对课程教学进行改革,建立高素质技能型人才培养目标下“知识-能力-实践”课程教学体系,探索课程建设和人才培养新模式,提高教学质量,构建现代职业院校发展新形态新范式。

Optimal Predictive Control for Path Following of a Full Drive-by-Wire Vehicle at Varying Speeds

The current research of the global chassis control problem for the full drive-by-wire vehicle focuses on the control allocation （CA） of the four-wheel-distributed trac- tion/braking/steering systems. However, the path following performance and the handling stability of the vehicle can be enhanced a step further by automatically adjusting the vehicle speed to the optimal value. The optimal solution for the combined longitudinal and lateral motion control （MC） problem is given. First, a new variable step-size spatial transformation method is proposed and utilized in the prediction model to derive the dynamics of the vehicle with respect to the road, such that the tracking errors can be explicitly obtained over the prediction horizon at varying speeds. Second, a nonlinear model predictive con- trol （NMPC） algorithm is introduced to handle the non- linear coupling between any two directions of the vehicular planar motion and computes the sequence of the optimal motion states for following the desired path. Third, a hierarchical control structure is proposed to separate the motion controller into a NMPC based path planner and a terminal sliding mode control （TSMC） based path fol- lower. As revealed through off-line simulations, the hier- archical methodology brings nearly 1700% improvement in computational efficiency without loss of control per- formance. Finally, the control algorithm is verified through a hardware in-the-loop simulation system. Double-lane- change （DLC） test results show that by using the optimalpredictive controller, the root-mean-square （RMS） values of the lateral deviations and the orientation errors can be reduced by 41% and 30%, respectively, comparing to those by the optimal preview acceleration （OPA） driver model with the non-preview speed-tracking method. Additionally, the average vehicle speed is increased by 0.26 km/h with the peak sideslip angle suppressed to 1.9~. This research proposes a novel motion controller, which provides the full drive-by-wire vehicle with better lane-keeping and colli- sion-avoidance capabilities during autonomous driving.

Oxidation combined with Maillard reaction induced free and protein-bound N^ε-carboxymethyllysine and Nε-carboxyethyllysine formation during braised chicken processing

The objective of this work was to investigate the effects of oxidation and Maillard reaction on free and protein-bound N^ε-carboxymethyllysine(CML)and Nε-carboxyethyllysine(CEL)formation during braised chicken processing.It was found that a positive correlation was observed between carbonyl,fat oxidation,Maillard reaction,CML and CEL(P<0.05).The sulfhydryl groups could be used as potential indicators to evaluate the compounds’interaction levels between Maillard reaction and protein oxidation.Frying promoted the formation of lysine(Lys),glyoxal(GO)and methylglyoxal(MGO)(P<0.05);boiling enhanced the formation of GO and MGO(P<0.05)while inhibited the levels of Lys(P<0.05);sterilizing blocked the formation of MGO and Lys(P<0.01)but improved GO levels(P<0.05).Finally,a perspective was concluded that the Maillard reaction combined with oxidation is one of the main reasons for the formation of free and protein-bound CML and CEL during braised chicken processing.

学龄前男童营养状况与尿促性腺激素及性激素水平的关系研究

背景营养状况可能影响儿童体内促性腺激素(Gn)和性激素水平,目前主要是对7岁以上儿童血液中激素的研究,且研究样本量较小。目的观察不同营养状况学龄前男童的尿Gn(UGn)、尿性激素水平,为无创性UGn和尿性激素的流行病学研究和临床应用提供参考依据。方法 2015年5月-2016年12月选取江苏省无锡市马山和胡埭社区学龄前男童(3岁≤年龄<7岁)为研究对象,测量其身高、体质量,计算其年龄别身高Z评分(HAZ)、年龄别体质量Z评分(WAZ)、体质指数(BMI)、年龄别体质指数Z评分(BAZ),并根据HAZ、WAZ、BAZ评分将其各分为6组。留取学龄前男童过夜晨尿,采用免疫化学发光法检测尿黄体生成素(ULH)、尿卵泡刺激素(UFSH)、尿雌三醇(UE3)、尿雌二醇(UE2)、尿睾酮(UT)。采用Kruskal-Wallis H检验进行多组间差异性比较,采用Kruskal-Wallis单因素方差分析进行多组间两两差异性比较,采用Spearman秩相关进行相关性分析。结果符合本研究纳入标准并成功留尿的学龄前男童共871例,ULH、UFSH、UE3、UE2、UT的检出率分别为6.7%(58/871)、99.4%(866/871)、99.7%(868/871)、99.8%(869/871)、98.0%(854/871)。不同HAZ组间UE3比较,差异有统计学意义(P<0.05),其中He、Hf组均高于Hc组,He组高于Hd组(P<0.05);各组UE2比较,差异有统计学意义(P<0.05),其中Hb组高于Ha、Hc、Hd组,He、Hf组高于Hc组(P<0.05);各组UT比较,差异有统计学意义(P<0.05),其中He、Hf组均高于Hc组,He组高于Hd组(P<0.05)。不同WAZ组间UFSH比较,差异有统计学意义(P<0.05),其中Wf组高于Wc、Wd、We组(P<0.05);各组UE3比较,差异有统计学意义(P<0.05),其中Wf组高于Wc、Wd、We组(P<0.05);各组UE2比较,差异有统计学意义(P<0.05),其中Wc组低于Wb组,Wf组高于Wc、Wd、We组(P<0.05);各组UT比较,差异有统计学意义(P<0.05),其中Wf组高于Wc、Wd、We组(P<0.05)。不同BAZ组间UFSH比较,差异有统计学意义(P<0.05),其中Bf组高于Bb、Bc、Bd组(P<0.05);各组UE3比较,差异有统计学意义(P<0.05),其中Bd组低于Bb组,Bf组高于Bc、Bd、Be组(P<0.05);各组UE2比较,差异有统计学意义(P<0.05),其中Bd组低于Bb组,Bf组高于Bc、Bd、Be组(P<0.05);各组UT比较,差异有统计学意义(P<0.05),其中Bf组高于Bb、Bc、Bd、Be组(P<0.05)。相关性分析结果显示UFSH与身高(rs=0.095)呈正相关(P<0.05),UE3与HAZ(rs=0.106)、身高(rs=0.231)、WAZ(rs=0.082)、BAZ(rs=0.106)、BMI(rs=0.084)均呈正相关(P<0.05),UE2与HAZ(rs=0.081)、身高(rs=0.164)、BAZ(rs=0.081)均呈正相关(P<0.05),UT与HAZ(rs=0.102)、身高(rs=0.217)、WAZ(rs=0.074)、体质量(rs=0.070)、BAZ(rs=0.102)、BMI(rs=0.080)均呈正相关(P<0.05)。结论学龄前男童尿液中ULH的含量较低,而其不同营养状况的UGn和尿性激素水平不同;随着短期营养状况的改善,其UE3、UE2、UT水平有升高的趋势;因此应该时刻关注学龄前男童的营养状况,保护学龄前男童的健康成长。

Optimal Design of Improved L-shaped Coprime Array Based on Difference and Sum Co-array

The concept of difference and sum co-array(DSCA)has become a new design idea for planar sparse arrays.Inspired by the shifting invariance property of DSCA,a specific configuration named here as the improved L-shaped array is proposed.Compared to other traditional 2D sparse array configurations such as 2D nested arrays and hourglass arrays,the proposed configuration has larger central consecutive ranges in its DSCA,thus increasing the DOF.At the same time,the mutual coupling effect is also reduced due to the enlarged spacing between the adjacent sensors.Simulations further demonstrate the superiority of the proposed arrays in terms of detection performance and estimation accuracy.

Glyoxal induced advanced glycation end products formation in chicken meat emulsion instead of oxidation

Advanced glycation end products(AGE) are potential harmful substances formed in the advanced Maillard reaction and increasingly investigated in muscle foods. However, the contribution of oxidation to the AGE formation is controversial. Moreover, reports on glyoxal(GO) induced AGE formation in chicken meat emulsion(CME) are limited. Thus, the effects of GO on emulsifying properties, rheological behavior and AGE formation in CME were investigated. Our findings exhibited that levels of Nε-carboxymethyllysine(CML) and Nε-carboxyethyllysine(CEL) were associated with lipid oxidation but not significantly(P > 0.05). Levels of AGE peaked when GO concentration ranged from 5 mmol/L(CML) to 10 mmol/L(CEL). The droplets’ aggregation associated with the disulfide bond when the concentration of GO was at 0.5–30 mmol/L while non-disulfide bond association occurred at 30–50 mmol/L GO concentration. In conclusion, compared to the effect of oxidation, GO exhibited the main role in the AGE formation of CME. This study will provide theoretical significance for further understanding and controlling the formation of AGE in CME.

Clinical observations of acute onset of myopic optic neuropathy in a real-world setting

AIM: To describe the clinical features of acute myopic onset of optic neuropathy and observe the effects of retrobulbar and systemic glucocorticoid therapy in a realworld setting.METHODS: A retrospective observational case series included 18 patients with a clinical diagnosis of acute onset of myopic optic neuropathy in a real-world setting. While the patients were using retrobulbar and systemic glucocorticoid therapy, various imaging examination data were analysed, and the clinical features of myopic optic neuropathy were summarized for 6 mo to 2 y. RESULTS: The included group of patients with acute onset of myopic optic neuropathy consisted mostly of females(n=11). The visual field(VF) showed abnormalities in bilateral eyes, including the spread of physiological blind spots, central and paracentral dark spots, and centripetal peripheral VF reduction;but central vision with no subjective changes. The visual evoked potential(VEP) was abnormal in all eyes with vision loss. The best corrected visual acuity(BCVA) was improved from 1.04±0.63 to 0.47±0.57(log MAR) af ter glucocor ticoid treatment(P<0.05). In patients with a short course(within 1 wk), recovery was fast and achieved the same BCVA as recorded before the onset within 6 d. However, in patients with the long course(1 to 2 wk), recovery was slow and did not achieve the BCVA recorded before the onset within 10 d. The changes of intraocular pressure(IOP) were not obvious before and after treatment(18.68±5.30 vs 19.55±5.34 mm Hg, P>0.05). There was no recurrence during long-term followup observation.CONCLUSION: The acute onset of myopic optic neuropathy is characterized by BCVA and VF abnormalities in bilateral eyes. Retrobulbar and systemic glucocorticoid therapy is effective.

Aerodynamics and Flight Dynamics of Free-Falling Ash Seeds

Samaras or winged seeds spread themselves by wind. Ash seed, unlike other samaras, has a high aspect ratio wing which can generate enough lift force to slow down descent by rotating about the vertical axis and spinning around its wing span axis simultaneously. This unique kinematics and inherent fluid mechanism are definitely of great interest. Detailed kinematics of free falling ash seeds were measured using high-speed cameras, then corresponding aerodynamic forces and moments were calculated employing computational fluid dynamics. The results show that both rotating and spinning directions are in the same side and the spinning angular velocity is about 6 times of rotating speed. The terminal descending velocity and cone angles are similar to other samaras. Analysis of the forces and moments shows that the lift is enough to balance the weight and the vertical rotation results from a processional motion of total angular moment because the spin-cycle-averaged aer-odynamic moment is perpendicular to the total angular moment and can only change its direction but maintain its magnitude, which is very similar to a spinning top in processional motion except that the total angular moment of ash seed is not along the spin axis but almost normal to it. The flow structures show that both leading and trailing edge vortices contribute to lift generation and the spanwise spinning results in an augmentation of the lift, implying that ash seeds with high aspect ratio wing may evolve in a different way in utilizing fluid mechanisms to facilitate dispersal.

二维超声检查与ABUS在乳腺微小结节良恶性鉴别中的诊断效能

目的:探究二维超声检查与自动乳腺超声诊断系统(ABUS)在乳腺微小结节良恶性鉴别中的诊断价值。方法:选择本院2018年10月-2020年2月收治的经病理检查明确为乳腺微小结节患者80例(111个结节),所有患者均行二维超声及ABUS检查。比较不同检查方法在各象限中乳腺微小结节的检出情况,分析二维超声、ABUS在乳腺微小结节良恶性诊断中的应用价值,另分析二维超声及ABUS检查与病理检查结果的一致性。结果:ABUS乳腺微小结节检出率均高于二维超声,差异有统计学意义(P<0.05);ABUS鉴别诊断乳腺微小结节良恶性的灵敏度、特异度、准确度均高于二维超声,差异有统计学意义(P<0.05)。Kappa检验显示:ABUS与病理结果的一致性良好(Kappa=0.891,P=0.000);二维超声与病理结果的一致性不佳(Kappa=0.396,P=0.000)。结论:与二维超声检查相比,采用ABUS在诊断乳腺微小结节良恶性中应用价值较高,能够明确结节位置,为临床诊断提供参考依据,值得推广应用。

青春期少年1607例臂-踝脉搏波速度分析

目的探讨臂-踝脉搏波速度(BaPWV)在青春期少年人群中的分布特点。方法采用横断面调查研究。2020年6月至2021年5月选自北京市海淀区5所中学的12~17岁青春期少年1607例。其中男782例,女825例。测量其血压、体质量、身高后,计算体质量指数(BMI),采用动脉硬化检测仪测量BaPWV。多组计量资料差异性比较采用单因素方差分析,其中2组间的差异性比较采用LSD法。2组计量资料的差异性比较采用两独立样本t检验,相关性分析采用Pearson相关分析。结果12~17岁青春期少年的BaPWV中位数水平随着年龄的增长呈现逐渐增加的趋势,由12岁BaPWV中位数982.50 cm/s,呈逐渐上升趋势,至17岁时达到最高值1113.50 cm/s,12~17岁青少年的BaPWV与年龄呈正相关(r=0.936,P=0.006)。在区分了性别的人群研究中,12岁男性和女性的BaPWV中位数分别为962.25 cm/s和997.50 cm/s,均随年龄递增呈逐渐上升趋势,至17岁时男性和女性的BaPWV中位数分别达到1122.50 cm/s和1096.00 cm/s,男性和女性的BaPWV均与年龄呈正相关(r=0.903,P=0.014;r=0.945,P=0.004)。男性BaPWV与收缩压、舒张压、年龄、体质量、身高、BMI均呈正相关(r=0.308,P<0.001;r=0.289,P<0.001;r=0.478,P<0.001;r=0.190,P<0.001;r=0.315,P<0.001;r=0.109,P=0.002)。女性BaPWV也与收缩压、舒张压、年龄、体质量、身高、BMI均呈正相关(r=0.340,P<0.001;r=0.285,P<0.001;r=0.379,P<0.001;r=0.115,P=0.001;r=0.170,P=0.001;r=0.097,P=0.014)。整体人群中肥胖组与正常组之间的BaPWV比较差异有统计学意义(t=-3.428,P=0.001)。在性别方面的比较显示:12~13岁组的男女之间BaPWV比较差异无统计学意义(t=0.123,P=0.902),但在14~15岁组和16~17岁组中,男女之间BaPWV比较差异均有统计学意义(t=2.315,P=0.021;t=2.152,P=0.032),均表现为女性平均BaPWV水平低于同组男性。结论12~17岁青春期少年的BaPWV水平随着年龄的增长呈现逐渐增高趋势。收缩压、舒张压、体质量、BMI、年龄、身高均与BaPWV呈正相关。肥胖可增加其血管僵硬度。不同性别的青春期发育对血管僵硬度有不同影响。

基于典型事故场景的雪天高速换道自动驾驶策略

针对雪天低附道路下的车辆高速换道安全问题,提出了一种智能汽车高速安全换道自动驾驶策略。基于典型交通事故案例,研究了车辆雪天高速换道安全特性。构建了Gaussian分布换道轨迹模型,利用决策树和分层加权评分,提出了适应不同驾驶模式的车路协同安全换道决策和路径规划方法。基于PreScan再现交通事故场景,验证低附路面下车辆高速换道智能驾驶策略。仿真结果表明:提出的自动驾驶决策规划机制可有效避免交通事故的发生,可为智能驾驶决策系统开发提供参考。

Cycle stability of lithium/garnet/lithium cells with different intermediate layers

The garnet-type electrolytes such as Ta-doped Li7La3Zr2Ol2 （LLZTO） have been viewed as the promising electrolytes for solid-state lithium batteries, but it exhibits problem of high interfacial resistance （1960 Ω·cm^2） and short circuit when being cycled in Li/LLZTO/Li cells at the current density above 0.5 mA·cm^-2. Introduction of intermediate layers in between lithium and LLZTO is helpful for decreasing the interfacial resistance and suppressing the growth of lithium dendrites. In this work, three kinds of intermediate layers of Au, Nb and Si with the thickness of 100 nm were prepared. Although the interfacial resistance with the Au layer decreases from 1960 to 32 Ω·cm^2, the cells can only cycle for 0.67 h at 0.5 mA·cm^-2, related to the Au peeled off from the LLZTO. The Nb layers lead to the initial interfacial resistance of 14 Ω·cm^2, while showing extension of cycle time to 50 h with the increase in interracial resistance due to the formation of the resistive Li-Nb-O phase. The Si layers induce the interfacial resistance as low as 5 Ω·cm^2 and the cycles as long as 120 h, which is attributed to the improvement in electrical contact between Li and electrolyte as well as the maintenance of conductive interface during cycles.

Acoustofluidic separation of cells andparticles

Acoustofluidics,the integration of acoustics and microfluidics,is a rapidly growing research field that is addressing challenges in biology,medicine,chemistry,engineering,and physics.In particular,acoustofluidic separation of biological targets from complex fluids has proven to be a powerful tool due to the label-free,biocompatible,and contact-free nature of the technology.By carefully designing and tuning the applied acoustic field,cells and other bioparticles can be isolated with high yield,purity,and biocompatibility.Recent advances in acoustofluidics,such as the development of automated,point-of-care devices for isolating sub-micron bioparticles,address many of the limitations of conventional separation tools.More importantly,advances in the research lab are quickly being adopted to solve clinical problems.In this review article,we discuss working principles of acoustofluidic separation,compare different approaches of acoustofluidic separation,and provide a synopsis of how it is being applied in both traditional applications,such as blood component separation,cell washing,and fluorescence activated cell sorting,as well as emerging applications,including circulating tumor cell and exosome isolation.

Machine learning models for outcome prediction of Chinese uveal melanoma patients: A 15-year follow-up study

Dear Editor Uveal melanoma(UM)is the most frequent primary malig-nant intraocular tumor in adults with an estimated inci-dence of 4-5 per million per year in western countries[1].About 50%of UM patients eventually develop metas-tasis.In a previous study,the prognosis of Chinese UM was mainly correlated with visual clinical features and gene sequencing results.Models designed to predict UM prognosis have been previously described[2],but these studies were based on Caucasians,not Chinese.

Building a bridge between ecology and Chinese herbal medicines

The modernization of traditional Chinese medicine(TCM) industry not only needs inheritance and development of the theory of TCM, but also requires application modern science and technology of related fields(Liu, 2016).