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Research and application of composite stochastic resonance in enhancement detection
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作者 高蕊 焦尚彬 薛琼婕 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第1期264-273,共10页
Aiming at the problem that the intermediate potential part of the traditional bistable stochastic resonance model cannot be adjusted independently, a new composite stochastic resonance(NCSR) model is proposed by combi... Aiming at the problem that the intermediate potential part of the traditional bistable stochastic resonance model cannot be adjusted independently, a new composite stochastic resonance(NCSR) model is proposed by combining the Woods–Saxon(WS) model and the improved piecewise bistable model. The model retains the characteristics of the independent parameters of WS model and the improved piecewise model has no output saturation, all the parameters in the new model have no coupling characteristics. Under α stable noise environment, the new model is used to detect periodic signal and aperiodic signal, the detection results indicate that the new model has higher noise utilization and better detection effect.Finally, the new model is applied to image denoising, the results showed that under the same conditions, the output peak signal-to-noise ratio(PSNR) and the correlation number of NCSR method is higher than that of other commonly used linear denoising methods and improved piecewise SR methods, the effectiveness of the new model is verified. 展开更多
关键词 Woods–Saxon improved piecewise model composite stochastic resonance(SR) image denoising
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Construction and Practice of a Practical Teaching System for Normal Universities Based on Ability Cultivation
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作者 rui gao Li Yang 《Open Journal of Applied Sciences》 2023年第10期1704-1713,共10页
This study aims to explore the effect of project-based teaching methods on improving students’ abilities in normal universities. This study delves into the practice teaching system based on ability training implement... This study aims to explore the effect of project-based teaching methods on improving students’ abilities in normal universities. This study delves into the practice teaching system based on ability training implemented in normal universities, examining the application of this teaching model in teacher education and the potential challenges it may encounter. Our case study reveals that the Project-Based Learning (PBL) approach can effectively transform students from passive recipients of knowledge into active problem solvers, thereby enhancing their critical thinking, problem-solving, teamwork, and communication skills. However, challenges do exist, including ensuring active participation from all students, providing equal opportunities for each student to develop and showcase their abilities, and completing complex projects within a limited timeframe. Therefore, teachers may need to adjust their teaching strategies, and schools need to provide more resources and support. These adjustments can help the practice teaching system based on ability training better serve teacher education and offer students a higher-quality educational experience. 展开更多
关键词 Ability Training Practice Teaching Project-Based Learning Critical Thinking Problem Solving
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Elaborately tuning the electronic structure of single-atom nickel sites using nickel nanoparticles to markedly enhance the electrochemical reduction of nitrate into ammonia
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作者 Zichao Xi Jiaqian Wang +4 位作者 Baocang Liu Xuan Xu Peng Jing rui gao Jun Zhang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第8期32-42,I0003,共12页
The electrochemical reduction of nitrate to ammonia(NH3) can be used to recycle nitrogen and offers a decarbonized route for sustainable NH3production,but requires efficient electrocatalysts.Herein,we have rationally ... The electrochemical reduction of nitrate to ammonia(NH3) can be used to recycle nitrogen and offers a decarbonized route for sustainable NH3production,but requires efficient electrocatalysts.Herein,we have rationally designed and fabricated a novel self-supported electrocatalyst comprised of Ni nanoparticles(NiNPs) embedded in Ni single atoms(NiSAs) anchored to nitrogen-doped carbon nanotubes grown on carbon cloth(NiNPs@NiSAs-NCNTs/CC) used for an efficient nitrate reduction reaction(NO3-RR) to produce NH_(3).The electrocatalyst can attain a maximum NH3yield rate of 27.67±1.16 mgNH3h^(-1)cm^(-2)at-1.4 V vs.reversible hydrogen electrode(RHE) and nearly 100% Faradic efficiency in the range of-1.2--1.4 V vs.RHE in a neutral medium,outperforming the previously reported Ni-based catalysts.Our experimental analysis and theoretical calculations have demonstrated that the moderate electrondeficient state of NiSAsregulated by NiNPsnot only facilitates the enrichment of NO_(3)^(-),but also benefits the formation of NO3*and decrease in the energy barrier of the rate-limiting step,thus resulting in the enhanced NO3-RR performance. 展开更多
关键词 Nitratereductionreaction Moderateelectron-deficient state Self-supported ELECTROCATALYST Enrichmentof NO_(3)^(-) Theoreticalcalculations
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Mantle sources of Cenozoic volcanoes around the South China Sea revealed by geochemical and isotopic data using the principal component analysis
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作者 Shuangshuang CHEN Zewei WANG +1 位作者 rui gao Yongzhang ZHOU 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第2期562-574,共13页
Principal component analysis(PCA)was employed to determine the implications of geochemical and isotopic data from Cenozoic volcanic activities in the Southeast Asian region,including China(South China Sea(SCS),Hainan ... Principal component analysis(PCA)was employed to determine the implications of geochemical and isotopic data from Cenozoic volcanic activities in the Southeast Asian region,including China(South China Sea(SCS),Hainan Island,Fujian-Zhejiang coast,Taiwan Island),and parts of Vietnam and Thailand.We analyzed 15 trace element indicators and 5 isotopic indicators for 623 volcanic rock samples collected from the study region.Two principal components(PCs)were extracted by PCA based on the trace elements and Sr-Nd-Pb isotopic ratios,which probably indicate an enriched oceanic island basalt-type mantle plume and a depleted mid-ocean ridge basalt-type spreading ridge.The results show that the influence of the Hainan mantle plume on younger volcanic activities(<13 Ma)is stronger than that on older ones(>13 Ma)at the same location in the Southeast Asian region.PCA was employed to verify the mantle-plume-ridge interaction model of volcanic activities beneath the expansion center of SCS and refute the hypothesis that the tension of SCS is triggered by the Hainan plume.This study reveals the efficiency and applicability of PCA in discussing mantle sources of volcanic activities;thus,PCA is a suitable research method for analyzing geochemical data. 展开更多
关键词 volcanic rocks geochemical indicators mantle source principal component analysis South China Sea
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Weak signal detection method based on novel composite multistable stochastic resonance
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作者 焦尚彬 高蕊 +1 位作者 薛琼婕 史佳强 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第5期178-187,共10页
The weak signal detection method based on stochastic resonance is usually used to extract and identify the weak characteristic signal submerged in strong noise by using the noise energy transfer mechanism.We propose a... The weak signal detection method based on stochastic resonance is usually used to extract and identify the weak characteristic signal submerged in strong noise by using the noise energy transfer mechanism.We propose a novel composite multistable stochastic-resonance(NCMSR)model combining the Gaussian potential model and an improved bistable model.Compared with the traditional multistable stochastic resonance method,all the parameters in the novel model have no symmetry,the output signal-to-noise ratio can be optimized and the output amplitude can be improved by adjusting the system parameters.The model retains the advantages of continuity and constraint of the Gaussian potential model and the advantages of the improved bistable model without output saturation,the NCMSR model has a higher utilization of noise.Taking the output signal-to-noise ratio as the index,weak periodic signal is detected based on the NCMSR model in Gaussian noise andαnoise environment respectively,and the detection effect is good.The application of NCMSR to the actual detection of bearing fault signals can realize the fault detection of bearing inner race and outer race.The outstanding advantages of this method in weak signal detection are verified,which provides a theoretical basis for industrial practical applications. 展开更多
关键词 weak signal detection composite multistable stochastic resonance bearing fault detection
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Quality influencing factors of dispersion curves from short period dense arrays based on a convolutional neural network across the north section of the Xiaojiang fault area
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作者 Si Chen rui gao +5 位作者 Zhanwu Lu Yao Liang Wei Cai Lifu Cao Zilong Chen Guangwen Wang 《Earthquake Science》 2023年第3期200-211,共12页
The number of dispersion curves increases significantly when the scale of a short-period dense array increases.Owing to a substantial increase in data volume,it is important to quickly evaluate dispersion curve qualit... The number of dispersion curves increases significantly when the scale of a short-period dense array increases.Owing to a substantial increase in data volume,it is important to quickly evaluate dispersion curve quality as well as select the available dispersion curve.Accordingly,this study quantitatively evaluated dispersion curve quality by training a convolutional neural network model for ambient noise tomography using a short-period dense array.The model can select high-quality dispersion curves that exhibit a≤10%difference between the results of manual screening and the proposed model.In addition,this study established a dispersion curve loss function by analyzing the quality of the dispersion curve and the corresponding influencing factors,thereby estimating the number of available dispersion curves for the existing observation systems.Furthermore,a Monte Carlo simulation experiment is used to illustrates the station-pair interval distance probability density function,which is independent of station number in the observational system with randomly deployed stations.The results suggested that the straight-line length should exceed 15 km to ensure that loss rate of dispersion curves remains<0.5,while maintaining the threshold ambient noise tomography accuracy within the study area. 展开更多
关键词 convolutional neural network ambient noise tomography dispersion curve
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Study on the Risk Factors of Central Venous-Related Bloodstream Infection in Outpatients
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作者 Lu Yan Cuiyu Han +2 位作者 Xuerun Du Yujie Gu rui gao 《Journal of Clinical and Nursing Research》 2023年第4期120-125,共6页
Objective:To analyze the risk factors of catheter-related bloodstream infection in outpatients and propose feasible prevention and control measures.Methods:The medical records of outpatients with peripherally inserted... Objective:To analyze the risk factors of catheter-related bloodstream infection in outpatients and propose feasible prevention and control measures.Methods:The medical records of outpatients with peripherally inserted central catheter(PICC)from January 2020 to December 2021 were selected for retrospective analysis,and the factors that may be related to the occurrence of catheter-related bloodstream infection were analyzed by logistic multivariate analysis.Results:The incidence rate of catheter-related bloodstream infection among the enrolled patients was 4.78%.It was found that age,duration of catheterization,catheter site,number of punctures,and diabetes were all risk factors for catheter-associated bloodstream infection,and the differences were statistically significant.Conclusion:Age,duration of catheterization,catheterization site,and diabetes are all risk factors for catheter-related bloodstream infection,and medical personnel should fully understand and learn more about these risk factors and actively develop countermeasures to reduce the risk of catheter-related bloodstream infection. 展开更多
关键词 OUTPATIENT Central venous catheter Bloodstream infection
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紫外/氯工艺中磺胺类药物的转化:机理和毒性评价 被引量:1
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作者 高睿 杨潇 +3 位作者 冯天宇 贾晓蕊 周庆 李爱民 《环境化学》 CAS CSCD 北大核心 2021年第5期1319-1329,共11页
磺胺类药物(sulfonamides,SAs)是一种常用的抗菌药物,由于在水生环境中经常被发现,因此备受关注。本文研究了紫外/氯(UV/Cl)工艺中3种磺胺类药物的转化过程及其产物毒性变化,并与氯化、紫外/过氧化氢(UV/H_(2)O_(2))工艺进行比较。结果... 磺胺类药物(sulfonamides,SAs)是一种常用的抗菌药物,由于在水生环境中经常被发现,因此备受关注。本文研究了紫外/氯(UV/Cl)工艺中3种磺胺类药物的转化过程及其产物毒性变化,并与氯化、紫外/过氧化氢(UV/H_(2)O_(2))工艺进行比较。结果显示,磺胺类药物在UV/Cl工艺中转化效率最高,氯类自由基在其中起到关键作用。在不同pH条件下,磺胺类药物在UV/Cl工艺中的转化效率会随pH值的增加而降低,但在pH值接近pKa值时突然升高,推测该现象与反应活性成分和SAs形态的变化有关。此外,对转化产物毒性的进一步研究发现,UV/Cl工艺的转化产物毒性最低(发光菌抑制率为6.99%—12.06%),但是未能显著降低SAs原溶液的毒性,并且由于氯代产物的出现,磺胺噻唑在转化后表现出更高的毒性。 展开更多
关键词 磺胺类药物 紫外/氯工艺 PH 动力学 水处理 毒性
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金属卟啉修饰的多孔聚苯胺基氧还原电催化剂 被引量:1
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作者 韩洪仨 王彦青 +5 位作者 张云龙 丛媛媛 秦嘉琪 高蕊 柴春晓 宋玉江 《物理化学学报》 SCIE CAS CSCD 北大核心 2021年第9期201-210,共10页
碳基非金属氧还原(ORR)电催化剂的研究近年来发展迅速,通过掺入杂原子等方法虽获得了一定的ORR活性,但仍需进一步提高。以此类电催化剂为基体,引入更多的活性位点,有可能获得更好的ORR活性。本文首先以带负电荷的SiO_(2)纳米球通过静电... 碳基非金属氧还原(ORR)电催化剂的研究近年来发展迅速,通过掺入杂原子等方法虽获得了一定的ORR活性,但仍需进一步提高。以此类电催化剂为基体,引入更多的活性位点,有可能获得更好的ORR活性。本文首先以带负电荷的SiO_(2)纳米球通过静电作用吸附带正电荷的质子化苯胺分子,再通过聚合反应实现聚苯胺(PANI)对SiO_(2)纳米球的包覆,之后将四甲氧基苯基铁卟啉(FeP)沉积在PANI表面,经高温热解,并去除SiO_(2)模板,得到了一种新型的多孔ORR电催化剂。在0.1 mol·L^(−1) KOH水溶液中,电催化剂的ORR半波电位达0.843 V(vs.可逆氢电极(RHE)),优于文献报道的大部分碳基非金属ORR电催化剂,与商业Pt/C相近。显著提高的ORR活性可能源于孔结构(平均孔径18 nm,孔容1.1 cm^(3)·g^(−1))、高比表面积(687.5 m^(2)·g^(−1))和高氮含量(6.4%)。在加速耐久性测试中,电催化剂的ORR半波电位衰减25 mV,与其它碳基非金属ORR电催化剂相当,且远优于商业Pt/C(衰减74 mV)。另外,电催化剂应用于氢氧根交换膜燃料电池(HEMFC)时的单池峰值功率密度达42 mW·cm−2。 展开更多
关键词 金属卟啉 聚苯胺 模板 多孔材料 氧还原反应
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High-resolution crustal structure of the Yinchuan basin revealed by deep seismic reflection profiling:implications for deep processes of basin 被引量:8
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作者 Xing fuHuang Shaoying Feng +1 位作者 rui gao Wenhui Li 《Earthquake Science》 CSCD 2016年第2期83-92,共10页
The Yinchuan basin, located on the western margin of the Ordos block, has the characteristics of an active continental rift. A NW-striking deep seismic reflection profile across the center of Yinchuan basin precisely ... The Yinchuan basin, located on the western margin of the Ordos block, has the characteristics of an active continental rift. A NW-striking deep seismic reflection profile across the center of Yinchuan basin precisely revealed the fine structure of the crust. The images showed that the crust in the Yinchuan basin was characterized by vertical stratifications along a detachment located at a two-way travel time(TWT) of 8.0 s.The most outstanding feature of this seismic profile was the almost flat Mohorovicˇic′ discontinuity(Moho) and a high-reflection zone in the lower crust. This sub-horizontal Moho conflicts with the general assumption of an uplifted Moho under sedimentary basins and continental rifts, and may indicate the action of different processes at depth during the evolution of sedimentary basins or rifts.We present a possible interpretation of these deep processes and the sub-horizontal Moho. The high-reflection zone, which consists of sheets of high-density, mantlederived materials, may have compensated for crustal thinning in the Yinchuan basin, leading to the formation of a sub-horizontal Moho. These high-density materials may have been emplaced by underplating with mantlesourced magma. 展开更多
关键词 深地震反射剖面 银川盆地 地壳结构 深部过程 高分辨率 鄂尔多斯地块 岩浆底侵作用 大陆裂谷
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Frozen subduction in the Yangtze block:insights from the deep seismic profiling and gravity anomaly in east Sichuan fold belt 被引量:7
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作者 Xiaosong Xiong rui gao +2 位作者 Haiyan Wang Jisheng Zhang Lianghui Guo 《Earthquake Science》 CSCD 2016年第2期61-70,共10页
The Sichuan basin is the main part of the middle-upper Yangtze block, which has been experienced a long-term tectonic evolution since Archean. The Yangtze block was regarded as a stable block until the collision with ... The Sichuan basin is the main part of the middle-upper Yangtze block, which has been experienced a long-term tectonic evolution since Archean. The Yangtze block was regarded as a stable block until the collision with the Cathaysia block in late Neoproterozoic. A new deep seismic reflection profile conducted in the eastern Sichuan fold belt(ESFB) discovered a serials of south-dipping reflectors shown from lower crust to the mantle imply a frozen subduction zone within the Yangtze block. In order to prove the speculation, we also obtain the middle-lower crustal gravity anomalies by removing the gravity anomalies induced by the sedimentary rocks and the mantle beneath the Moho, which shows the mid-lower crustal structure of the Sichuan basin can be divided into eastern and western parts. Combined with the geochronology and Aeromagnetic anomalies, we speculated the Yangtze block was amalgamated by the West Sichuan and East Sichuan blocks separated by the Huayin-Chongqing line. The frozen subduction zone subsequently shifted to a shear zone accommodated the lower crustal shortening when the decollement at the base of the Nanhua system functioned in the upper plate. 展开更多
关键词 四川盆地 华夏地块 重力异常 俯冲带 褶皱带 地震剖面 深地震反射剖面 冻结
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Stress distribution and surrounding rock control of mining near to the overlying coal pillar in the working face 被引量:6
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作者 rui gao Bin Yu Xiangbin Meng 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2019年第6期881-887,共7页
The occurrence of overlying coal pillar(OCP)exerts a strong effect on the stress and strain distribution of the surrounding rock in the stope.In this paper,the stress distribution characteristics are analyzed via the ... The occurrence of overlying coal pillar(OCP)exerts a strong effect on the stress and strain distribution of the surrounding rock in the stope.In this paper,the stress distribution characteristics are analyzed via the numerical calculation with the account of OCP presence or absence.In addition,this study revealed the joint effect of side pressure relief area of the goaf and stress concentration in OCP on the final stress distribution.Furthermore,the rules of abutment stress distribution affected by three influencing factors,namely horizontal-vertical distances between OCP and working face and buried depth of OCP,are analyzed.The functional model linking the peak stress of surrounding rock with the above influencing factors is developed.The field application of the above results proved that the rib spalling and deformation of a 2.95 m-high and 5.66 m-wide roadway could be efficiently controlled by rationally adjusting working states of the support,and adopting the hydraulic prop coordinated with the p type metal beam and anchor cable to strengthen the surrounding rock of working face and roadway,respectively.The proposed measures are considered appropriate to satisfy the safe operation requirements. 展开更多
关键词 Overlying COAL pillar(OCP) Stress distribution Influencing factors SURROUNDING ROCK control
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The thickness and structural characteristics of the crust across Tibetan plateau from active-sources seismic profiles 被引量:5
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作者 Qiusheng Li rui gao +6 位作者 Zhanwu Lu Ye Guan Jisheng Zhang Pengwu Li Haiyan Wang Rizheng He Marianne Karplus 《Earthquake Science》 CSCD 2009年第1期21-31,共11页
The Tibetan plateau as one of the youngest orogen on the Earth was considered as the result of continent-continent collision between the Eurasian and Indian plates.The thickness and structure of the crust beneath Tibe... The Tibetan plateau as one of the youngest orogen on the Earth was considered as the result of continent-continent collision between the Eurasian and Indian plates.The thickness and structure of the crust beneath Tibetan plateau is essential to understand deformation behavior of the plateau.Active-source seismic profiling is most available geo-physical method for imaging the structure of the continental crust.The results from more than 25 active-sources seismic profiles carried out in the past twenty years were reviewed in this article.A preliminary cross crustal pattern of the Tibetan Pla-teau was presented and discussed.The Moho discontinuity buries at the range of 60-80 km on average and have steep ramps located roughly beneath the sutures that are compatible with the successive stacking/accretion of the former Cenozoic blocks northeastward.The deepest Moho(near 80 km) appears closely near IYS and the crustal scale thrust system beneath southern margin of Tibetan plateau suggests strong dependence on collision and non-distributed deformation there.However,the ~20 km order of Moho offsets hardly reappears in the inline section across northern Tibetan plateau.Without a universally accepted,convincing dynamic explanation model accommodated the all of the facts seen in controlled seismic sections,but vertical thickening and northeastern shorten of the crust is quite evident and interpretable to a certain extent as the result of continent-continent collision.Simultaneously,weak geophysical signature of the BNS suggests that convergence has been accommodated perhaps partially through pure-shear thickening accompanied by removal of lower crustal material by lateral escape.Recent years the result of Moho with ~7 km offset and long extend in south-dip angle beneath the east Kunlun oro-gen and a grand thrust fault at the northern margin of Qilian orogen has attract more attention to action from the northern blocks.The broad lower-velocity area in the upper-middle crust of the Lhasa block was once considered as resulted from partially melted rocks.However the low normal vP/vS ratio and the Moho stepwise rise fail to support significant partial melting in the middle-lower crust of the central-northern Tibetan plateau.Furthermore,the lower-velocity of crust occasionally disappears,and/or local thinned exhibits their non-stationary spatial distribution. 展开更多
关键词 大陆地壳 西藏高原 地震剖面 结构 厚度 地球物理方法 东昆仑造山带 大陆碰撞
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A novel design of 3D carbon host for stable lithium metal anode 被引量:6
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作者 Hang Liu Jie Di +8 位作者 Ping Wang rui gao Han Tian Pengfei Ren Qingxi Yuan Wanxia Huang ruiping Liu Qiang Liu Ming Feng 《Carbon Energy》 SCIE CAS 2022年第4期654-664,共11页
Rational design of porous conductive hosts with high electrical conductivity,large surface area,and adequate interior space is desirable to suppressing dendritic lithium growth and accommodating large volume change of... Rational design of porous conductive hosts with high electrical conductivity,large surface area,and adequate interior space is desirable to suppressing dendritic lithium growth and accommodating large volume change of lithium metal anode during the Li plating/stripping process.However,due to the conductive nature of the conductive hosts,Li is easily deposited directly on the top of the hosts,which hinders it from fully functioning.To circumvent the issue,in this study,we designed a novel porous carbon host with a gradient-pore-size structure based on one-dimensional(1D)carbon with different diameters.With this kind of host,stable cycling with high and stable Coulombic efficiency of~98%is achieved at 0.5 mA cm^(−2) with an areal capacity of 1 mAh cm^(−2) over 320 cycles.In contrast,the normal three-dimensional(3D)carbon nanotube host presents a moss-like Li morphology with wildly fluctuating Coulombic efficiency after 100 cycles.The results reveal that the unique gradient-pore-size structure of the 3D conductive host greatly improves the performance of lithium metal batteries. 展开更多
关键词 3D conductive hosts anodes CARBON Li dendrites lithium metal batteries
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Development and application of rapid rehabilitation system for reconstruction of maxillofacial soft-tissue defects related to war and traumatic injuries 被引量:5
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作者 Shi-Zhu Bai Zhi-Hong Feng +4 位作者 rui gao Yan Dong Yun-Peng Bi Guo-Feng Wu Xi Chen 《Journal of Medical Colleges of PLA(China)》 CAS 2014年第1期59-65,共7页
Background: Maxillofacial war injuries usually cause severe facial organ defects and deformities, handicapping the patient's daily activities, even result in a tendency to commit suicide. The application of maxill... Background: Maxillofacial war injuries usually cause severe facial organ defects and deformities, handicapping the patient's daily activities, even result in a tendency to commit suicide. The application of maxillofacial prosthesis is an alternative to surgery in functional–aesthetic facial reconstruction. Computer aided design and computer aided manufacturing has opened up a new approach to the fabrication of maxillofacial prosthesis. An intelligentized rapid simulative design and manufacture system for prosthesis was developed to facilitate the prosthesis fabrication procedure.Methods: Maxillofacial prosthesis rapid simulation design and rapid fabrication system consists of three components: digital impression, intelligentized prosthesis designing, and rapid manufacturing. The patients' maxillofacial digital impressions were taken with Structured-light 3D scanner; and then the 3D model of prostheses and their negative molds could be designed in specific software; finally, with the resin molds fabricated by rapid prototyping machine, the prostheses could be produced directly and quickly.Results: Fifteen patients of maxillofacial defect caused by traumatic injuries received prosthesis rehabilitation provided by the established system. The contour of the prostheses coordinated properly with the appearance of the patients, and the uniform-thickness border sealed well to adjacent tissues. All the patients were satisfied with their prostheses.Conclusions: The rapid simulative rehabilitation system of maxillofacial defects has been approaching completion. It could provide advanced technological reservation for the Army in the issue of maxillofacial defect rehabilitation. 展开更多
关键词 CAD/CAM MAXILLOFACIAL DEFECT PROSTHESIS design def
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新冠病毒肺炎临床试验核心指标集 被引量:5
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作者 金鑫瑶 庞博 +32 位作者 张俊华 刘清泉 杨忠奇 封继宏 刘学政 张磊 王保和 黄宇虹 Alice Josephine Fauci 马玉玲 Myeong Soo Lee 元唯安 谢雁鸣 唐健元 高蕊 杜亮 张硕 祁寒梅 孙宇 郑文科 杨丰文 蔡慧姿 王可仪 欧益 黄明 朱彦 喻佳洁 田金徽 赵敏 胡镜清 姚晨 李幼平 张伯礼 《Engineering》 SCIE EI 2020年第10期1294-1300,共7页
自2019年12月新型冠状病毒肺炎(Coronavirus Disease 2019, COVID-19)暴发以来,已有大量相关临床研究完成注册或已启动。然而,不同研究间临床结局指标存在显著的异质性,同时一些不关键的指标会造成研究资源的浪费。本研究旨在构建COVID... 自2019年12月新型冠状病毒肺炎(Coronavirus Disease 2019, COVID-19)暴发以来,已有大量相关临床研究完成注册或已启动。然而,不同研究间临床结局指标存在显著的异质性,同时一些不关键的指标会造成研究资源的浪费。本研究旨在构建COVID-19临床试验核心结局指标集(core outcome set, COS),为相关临床研究方案设计、开展和证据转化提供参考。本研究的实施参照《有效性试验核心结局指标(COMET)手册》(1.0版),研究组成员包括呼吸系统和危重医学、中医学、循证医学、临床药理学、统计学专家以及医学杂志编辑等。通过检索临床试验注册网站(chictr.org.cn和clinicaltrials.gov)中COVID-19相关临床研究方案,提取方案中的结局指标,形成指标池。78个COVID-19临床试验方案纳入研究,收集结局指标259个,合并规范后确定132个结局指标,涉及7个指标域。经遴选,形成了包括58个结局指标在内的初始指标清单。经过两轮德尔菲调查和一轮共识会议,最终确立针对COVID-19不同临床分型的核心指标集(COS-COVID)。COS-COVID包括1个轻型指标(病毒核酸检测转阴时间)、4个普通型指标(住院时间、复合事件发生率、临床症状积分和病毒核酸检测转阴时间)、5个重型指标(复合事件发生率、住院时间、PaO2/FiO2、机械通气时间和病毒核酸检测转阴时间)、1个危重型指标(全因死亡率)及1个康复期指标(肺功能)。COS-COVID作为目前临床评价COVID-19干预效果最具临床价值及操作性的指标集合,对证据评估和决策具有重要意义。随着对疾病认知的不断深入和COS-COVID应用的反馈,课题组将对本核心指标集进行进一步完善并更新。 展开更多
关键词 核心指标集 COVID-19 2019-nCoV 冠状病毒疾病 临床试验
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Modified halloysite nanotubes reduce the toxic effects of zearalenone in gestating sows on growth and muscle development of their offsprings 被引量:3
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作者 rui gao Qingwei Meng +4 位作者 Jianan Li Min Liu Yuanyuan Zhang Chongpeng Bi Anshan Shan 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2016年第4期570-578,共9页
Background: Zearalenone(ZEN) is an estrogenic mycotoxin that is primarily produced by Fusarium fungi and has been proven to affect the reproductive capacity of many species to varying degrees. The present experiment w... Background: Zearalenone(ZEN) is an estrogenic mycotoxin that is primarily produced by Fusarium fungi and has been proven to affect the reproductive capacity of many species to varying degrees. The present experiment was designed to study the maternal persistent effects of zearalenone toxicity in gestating sows on growth and muscle development of their offsprings, and the alleviation of zearalenone toxicity by modified halloysite nanotubes(MHNTs).Methods: Eighteen sows were fed with one of three dietary treatments that included the following:(1) a control diet,(2) a contaminated grain diet(with 50 % moldy corn, 2.77 mg/kg ZEN), and(3) a contaminated grain diet(with 50 %moldy corn, 2.76 mg/kg ZEN) + 1 % MHNTs. Each sow was exclusively fed its experimental diets from 35 to 70 d of gestation at a total of 2 kg daily. Muscle samples were collected from six piglets per treatment at birth, weaning and finishing.Results: The results showed that feeding the sows with the ZEN-contaminated diets from 35 to 70 d of gestation decreased the ADG, ADFI and G:F of their offsprings(P < 0.05). The muscle fiber numbers in the newborn, weaning and growing-finishing pigs and the muscle fiber diameters at birth and weaning were also decreased by maternal ZEN exposure(P < 0.05). The expressions of IGF-I, IGF-II, Myf-5 and Mstn at birth and IGF-II, Pax7, Myf-5 and Myo D1 at weaning were altered by feeding gestating sows with ZEN-contaminated diets(P < 0.05). The MHNTs reduced most of the ZEN-induced toxic effects: the ADG and ADFI on growth performance, the muscle fiber numbers at weaning and finishing and the muscle fiber diameters at weaning(P < 0.05). The expression levels of IGF-II and Mstn in newborn piglets and IGF-II and Myf-5 in weaning piglets were also prevented by adding 1 % MHNTs(P < 0.05).Conclusions: The present study demonstrated that the offsprings of sows fed with ZEN-contaminated diets from 35 to 70 day of gestation exhibited weakening on growth performance, physiological changes in their muscle fibers and alterations of m RNA expression in their muscle tissues, and also indicated that MHNTs prevented most of the ZENinduced weakening in the muscle tissues. 展开更多
关键词 玉米赤霉烯酮 生长肥育猪 妊娠母猪 肌肉组织 毒性作用 埃洛石 后代 改性
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Modulational Instability of Trapped Two-Component Bose-Einstein Condensates 被引量:2
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作者 周建文 李晓旬 +4 位作者 高瑞 秦文山 蒋浩浩 李涛涛 薛具奎 《Chinese Physics Letters》 SCIE CAS CSCD 2019年第9期10-13,共4页
The modulational instability of two-component Bose-Einstein condensates(BECs)under an external parabolic potential is discussed.Based on the trapped two-component Gross-Pitaevskill equations,a time-dependent dispersio... The modulational instability of two-component Bose-Einstein condensates(BECs)under an external parabolic potential is discussed.Based on the trapped two-component Gross-Pitaevskill equations,a time-dependent dispersion relation is obtained analytically by means of the modified lens-type transformation and linear stability analysis.It is shown that a modulational unstable time scale exists for trapped two-component BECs.The modulational properties-which are determined by the wave number,external trapping parameter,intraand inter-species atomic interactions-are modified significantly.The analytical results are confirmed by direct numerical simulation.Our results provide a criterion for judging the occurrence of instability of the trapped two-component BECs in experiment. 展开更多
关键词 Modulational INSTABILITY of TRAPPED TWO-COMPONENT BOSE-EINSTEIN CONDENSATES COMPONENT
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Liver regeneration using decellularized splenic scaffold: a novel approach in tissue engineering 被引量:2
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作者 Jun-Xi Xiang Xing-Long Zheng +4 位作者 rui gao Wan-Quan Wu Xu-Long Zhu Jian-Hui Li Yi Lv 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2015年第5期502-508,共7页
BACKGROUND: The potential application of decellularized liver scaffold for liver regeneration is limited by severe shortage of donor organs. Attempt of using heterograft scaffold is accompanied with high risks of zoon... BACKGROUND: The potential application of decellularized liver scaffold for liver regeneration is limited by severe shortage of donor organs. Attempt of using heterograft scaffold is accompanied with high risks of zoonosis and immunological rejection. We proposed that the spleen, which procured more extensively than the liver, could be an ideal source of decellularized scaffold for liver regeneration. METHODS: After harvested from donor rat, the spleen was processed by 12-hour freezing/thawing ×2 cycles, then circulation perfusion of 0.02% trypsin and 3% Triton X-100 sequentially through the splenic artery for 32 hours in total to prepare decellularized scaffold. The structure and component characteristics of the scaffold were determined by hematoxylin and eosin and immumohistochemical staining, scanning electron microscope, DNA detection, porosity measurement, biocompatibility and cytocompatibility test. Recellularization of scaffold by 5×106 bone marrow mesenchymal stem cells(BMSCs) was carried out to preliminarily evaluate the feasibility of liver regeneration by BMSCs reseeding and differentiation in decellularized splenic scaffold.RESULTS: After decellularization, a translucent scaffold, which retained the gross shape of the spleen, was generated. Histological evaluation and residual DNA quantitation revealed the remaining of extracellular matrix without nucleus and cytoplasm residue. Immunohistochemical study proved the existence of collagens I, IV, fibronectin, laminin and elastin in decellularized splenic scaffold, which showed a similarity with decellularized liver. A scanning electron microscope presented the remaining three-dimensional porous structure of extracellular matrix and small blood vessels. The poros-ity of scaffold, aperture of 45.36±4.87 μm and pore rate of 80.14%±2.99% was suitable for cell engraftment. Subcutaneous implantation of decellularized scaffold presented good histocompatibility, and recellularization of the splenic scaffold demonstrated that BMSCs could locate and survive in the decellularized matrix. CONCLUSION: Considering the more extensive organ source and satisfying biocompatibility, the present study indicated that the three-dimensional decellularized splenic scaffold might have considerable potential for liver regeneration when combined with BMSCs reseeding and differentiation. 展开更多
关键词 细胞支架 肝再生 脾脏 组织工程 骨髓间充质干细胞 扫描电镜观察 生物相容性 细胞外基质
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Controlling mine pressure by subjecting high-level hard rock strata to ground fracturing 被引量:2
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作者 rui gao Tiejun Kuang +2 位作者 Yanqun Zhang Wenyang Zhang Chunyang Quan 《International Journal of Coal Science & Technology》 EI CAS CSCD 2021年第6期1336-1350,共15页
When mining extra-thick coal seams,the main cause of strong ground pressure are the high-level thick and hard strata,but as yet there is no active and effective control technology.This paper proposes the method of sub... When mining extra-thick coal seams,the main cause of strong ground pressure are the high-level thick and hard strata,but as yet there is no active and effective control technology.This paper proposes the method of subjecting hard roofs to ground fracturing,and physical simulation is used to study the control effect of ground fracturing on the strata structure and energy release.The results show that ground fracturing changes the structural characteristics of the strata and reduces the energy release intensity and the spatial extent of overburden movement,thereby exerting significant control on the ground pressure.The Datong mining area in China is selected as the engineering background.An engineering test was conducted on site by ground horizontal well fracturing,and a 20-m-thick hard rock layer located 110 m vertically above the coal seam was targeted as the fracturing layer.On-site microseismic monitoring shows that the crack propagation length is up to 216 m and the height is up to 50 m.On-site mine pressure monitoring shows that(1)the roadway deformation is reduced to 100 mm,(2)the periodic weighting characteristics of the hydraulic supports are not obvious,and(3)the ground pressure in the working face is controlled significantly,thereby showing that the ground fracturing is successful.Ground fracturing changed the breaking characteristics of the high-level hard strata,thereby helping to ameliorate the stress concentration in the stope and providing an effective control approach for hard rock. 展开更多
关键词 Ground fracturing High-level hard roof Breakage characteristics Pressure control Safety mining
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