Dear Editor Proline-rich antimicrobial peptides （PrAMPs） are a class of antimicrobial peptides containing a high content of proline residues. PrAMPs selectively target Gram-negative bacteria through special transpor...Dear Editor Proline-rich antimicrobial peptides （PrAMPs） are a class of antimicrobial peptides containing a high content of proline residues. PrAMPs selectively target Gram-negative bacteria through special transporters such as SmbA to enter cyto- plasm （Mattiuzzo et al., 2007）. On the other hand, PrAMPs present a low toxicity to mammalian cells, because they cannot effectively penetrate the mammalian cellular mem- brane （Hansen et al., 2012） or they are internalized through an endocytotic process to minimize interaction with cytosolic ribosomes （Tomasinsig et al., 2006）. Therefore, PrAMPs are promising candidates to treat infections and to deliver drugs （Schmidt et al., 2016）.展开更多
文摘Dear Editor Proline-rich antimicrobial peptides （PrAMPs） are a class of antimicrobial peptides containing a high content of proline residues. PrAMPs selectively target Gram-negative bacteria through special transporters such as SmbA to enter cyto- plasm （Mattiuzzo et al., 2007）. On the other hand, PrAMPs present a low toxicity to mammalian cells, because they cannot effectively penetrate the mammalian cellular mem- brane （Hansen et al., 2012） or they are internalized through an endocytotic process to minimize interaction with cytosolic ribosomes （Tomasinsig et al., 2006）. Therefore, PrAMPs are promising candidates to treat infections and to deliver drugs （Schmidt et al., 2016）.
