Inspired by structures of antenna-reaction centers in photosynthesis, the complex micelle was prepared from zinc tetra-phenyl porphyrin （ZnTPP）, fullerene derivative （PyC60） and poly（ethylene glycol）-block-poly...Inspired by structures of antenna-reaction centers in photosynthesis, the complex micelle was prepared from zinc tetra-phenyl porphyrin （ZnTPP）, fullerene derivative （PyC60） and poly（ethylene glycol）-block-poly（E-caprolactone） （PEG-b- PCL）. The core-shell structure made the hydrophobic donor-acceptor system work in aqueous. In micellar core, coordination interaction occurred between ZnTPP and PyC60 molecules which ensured the enhanced energy migration from the donor to the acceptor. The enhanced interaction between porphyrin and fullerene was confirmed by absorption, steady-state fluorescence and transient fluorescence. The generation of singlet oxygen and superoxide radical was detected by iodide method and reduction of nitro blue tetrazolium, respectively, which confirmed that electron transfer reaction in the complex micellar core occurred. Moreover, the complex micelle exhibited effective electron transfer performance in photodebromination of 2,3-dibromo-3-phenylpropionic acid. The complex micellar structure endowed the donor-acceptor system with improved stability under irradiation. This strategy could be helpful for designing new electron transfer platform and artificial photosynthetic system.展开更多
Phototherapy,including photodynamic therapy(PDT)and photothermal therapy(PTT),that employs phototherapeutic agents to generate cytotoxic reactive oxygen species(ROS)or hyperthermia,is a promising approach for disease ...Phototherapy,including photodynamic therapy(PDT)and photothermal therapy(PTT),that employs phototherapeutic agents to generate cytotoxic reactive oxygen species(ROS)or hyperthermia,is a promising approach for disease therapy.However,conventional organic phototherapeutic agents suffer poor photostability and aggregation-caused quenching(ACQ)in the aggregate state,restricting their therapeutic efficacy.Aggregation-induced emission(AIE)agents can solve these issues with strong emission in the aggregate state and reverse designation to generate heat.This review summarizes the recent advances in the development of AIE phototherapy agents for enhanced PDT and PTT performances in biomedical applications.First,design strategies of AIE agents that adjust the intersystem crossing process or intramolecular charge transfer to boost ROS generation or regulate ROS types are discussed.The AIE agents with ROS generation ability for biomedical applications including antitumor and antibacterial performances are then introduced.Next,designs and examples of AIE agents that enhance PTT performances through molecular motions are described.Finally,the current challenges and perspectives of AIE agents in the phototherapy field are discussed.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.91527306,51390483,21620102005,51603231 and 51503104)the Natural Science Foundation of Tianjin(Nos.16JCQNJC02500 and16JCQNJC03000)
文摘Inspired by structures of antenna-reaction centers in photosynthesis, the complex micelle was prepared from zinc tetra-phenyl porphyrin （ZnTPP）, fullerene derivative （PyC60） and poly（ethylene glycol）-block-poly（E-caprolactone） （PEG-b- PCL）. The core-shell structure made the hydrophobic donor-acceptor system work in aqueous. In micellar core, coordination interaction occurred between ZnTPP and PyC60 molecules which ensured the enhanced energy migration from the donor to the acceptor. The enhanced interaction between porphyrin and fullerene was confirmed by absorption, steady-state fluorescence and transient fluorescence. The generation of singlet oxygen and superoxide radical was detected by iodide method and reduction of nitro blue tetrazolium, respectively, which confirmed that electron transfer reaction in the complex micellar core occurred. Moreover, the complex micelle exhibited effective electron transfer performance in photodebromination of 2,3-dibromo-3-phenylpropionic acid. The complex micellar structure endowed the donor-acceptor system with improved stability under irradiation. This strategy could be helpful for designing new electron transfer platform and artificial photosynthetic system.
基金supported by the National Key R&D Program of China(nos.2017YFA0701301 and 2017YFA 0205400)National Natural Science Foundation of China(nos.51690153,21720102005,and 51903120)the Fundamental Research Funds for the Central Universities(no.020514913212).
文摘Phototherapy,including photodynamic therapy(PDT)and photothermal therapy(PTT),that employs phototherapeutic agents to generate cytotoxic reactive oxygen species(ROS)or hyperthermia,is a promising approach for disease therapy.However,conventional organic phototherapeutic agents suffer poor photostability and aggregation-caused quenching(ACQ)in the aggregate state,restricting their therapeutic efficacy.Aggregation-induced emission(AIE)agents can solve these issues with strong emission in the aggregate state and reverse designation to generate heat.This review summarizes the recent advances in the development of AIE phototherapy agents for enhanced PDT and PTT performances in biomedical applications.First,design strategies of AIE agents that adjust the intersystem crossing process or intramolecular charge transfer to boost ROS generation or regulate ROS types are discussed.The AIE agents with ROS generation ability for biomedical applications including antitumor and antibacterial performances are then introduced.Next,designs and examples of AIE agents that enhance PTT performances through molecular motions are described.Finally,the current challenges and perspectives of AIE agents in the phototherapy field are discussed.
