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The evolution of robotics:research and application progress of dental implant robotic systems 被引量:3
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作者 Chen Liu Yuchen Liu +3 位作者 rui xie Zhiwen Li Shizhu Bai Yimin Zhao 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第2期173-185,共13页
The use of robots to augment human capabilities and assist in work has long been an aspiration.Robotics has been developing since the 1960s when the first industrial robot was introduced.As technology has advanced,rob... The use of robots to augment human capabilities and assist in work has long been an aspiration.Robotics has been developing since the 1960s when the first industrial robot was introduced.As technology has advanced,robotic-assisted surgery has shown numerous advantages,including more precision,efficiency,minimal invasiveness,and safety than is possible with conventional techniques,which are research hotspots and cutting-edge trends.This article reviewed the history of medical robot development and seminal research papers about current research progress.Taking the autonomous dental implant robotic system as an example,the advantages and prospects of medical robotic systems would be discussed which would provide a reference for future research. 展开更多
关键词 ROBOT ROBOTIC APPLICATION
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Fully automatic AI segmentation of oral surgery-related tissues based on cone beam computed tomography images 被引量:1
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作者 Yu Liu rui xie +5 位作者 Lifeng Wang Hongpeng Liu Chen Liu Yimin Zhao Shizhu Bai Wenyong Liu 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第3期413-424,共12页
Accurate segmentation of oral surgery-related tissues from cone beam computed tomography(CBCT)images can significantly accelerate treatment planning and improve surgical accuracy.In this paper,we propose a fully autom... Accurate segmentation of oral surgery-related tissues from cone beam computed tomography(CBCT)images can significantly accelerate treatment planning and improve surgical accuracy.In this paper,we propose a fully automated tissue segmentation system for dental implant surgery.Specifically,we propose an image preprocessing method based on data distribution histograms,which can adaptively process CBCT images with different parameters.Based on this,we use the bone segmentation network to obtain the segmentation results of alveolar bone,teeth,and maxillary sinus.We use the tooth and mandibular regions as the ROI regions of tooth segmentation and mandibular nerve tube segmentation to achieve the corresponding tasks.The tooth segmentation results can obtain the order information of the dentition.The corresponding experimental results show that our method can achieve higher segmentation accuracy and efficiency compared to existing methods.Its average Dice scores on the tooth,alveolar bone,maxillary sinus,and mandibular canal segmentation tasks were 96.5%,95.4%,93.6%,and 94.8%,respectively.These results demonstrate that it can accelerate the development of digital dentistry. 展开更多
关键词 SURGERY CBCT BEAM
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Maximum Power Point Tracking Technology for PV Systems: Current Status and Perspectives
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作者 Bo Yang rui xie Zhengxun Guo 《Energy Engineering》 EI 2024年第8期2009-2022,共14页
Maximum power point tracking(MPPT)technology plays a key role in improving the energy conversion efficiency of photovoltaic(PV)systems,especially when multiple local maximum power points(LMPPs)occur under partial shad... Maximum power point tracking(MPPT)technology plays a key role in improving the energy conversion efficiency of photovoltaic(PV)systems,especially when multiple local maximum power points(LMPPs)occur under partial shading conditions(PSC).It is necessary to modify the operating point efficiently and accurately with the help of MPPT technology to maximize the collected power.Even though a lot of research has been carried out and impressive progress achieved for MPPT technology,it still faces some challenges and dilemmas.Firstly,the mathematical model established for PV cells is not precise enough.Second,the existing algorithms are often optimized for specific conditions and lack comprehensive adaptability to the actual operating environment.Besides,a single algorithm may not be able to give full play to its advantages.In the end,the selection criteria for choosing the suitable MPPT algorithm/converter combination to achieve better performance in a given scenario is very limited.Therefore,this paper systematically discusses the current research status and challenges faced by PV MPPT technology around the three aspects of MPPT models,algorithms,and hardware implementation.Through in-depth thinking and discussion,it also puts forward positive perspectives on future development,and five forward-looking solutions to improve the performance of PV systems MPPT are suggested. 展开更多
关键词 PV systems MPPT partial shading condition DC-DC converter
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人参皂苷Rh2对免疫低下小鼠的免疫调节作用 被引量:21
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作者 钱颖 黄容容 +5 位作者 孙锐 冯觉平 李森林 谢锐 胡钦予 向明 《医药导报》 CAS 北大核心 2018年第12期1446-1454,共9页
目的研究人参皂苷Rh2的免疫调控功能。方法 6周龄C57BL/6J雄性小鼠采用X射线一次性全身照射建立放疗模型,腹腔注射甲氨蝶呤建立免疫低下模型。两种模型均分为空白对照组(n=10)、模型对照组(n=15)、胸腺五肽组(n=15)、人参皂苷Rh2组(n=15... 目的研究人参皂苷Rh2的免疫调控功能。方法 6周龄C57BL/6J雄性小鼠采用X射线一次性全身照射建立放疗模型,腹腔注射甲氨蝶呤建立免疫低下模型。两种模型均分为空白对照组(n=10)、模型对照组(n=15)、胸腺五肽组(n=15)、人参皂苷Rh2组(n=15)。空白对照组和模型对照组按每只0.2 mL灌胃0.9%氯化钠溶液,胸腺五肽组按0.1 mg·kg^(-1)腹腔注射胸腺五肽,人参皂苷Rh2组按10 mg·kg^(-1)灌胃,每天1次。放疗模型于第3,5,7天取材,甲氨蝶呤致免疫低下模型第15天取材。采用流式细胞术检测脾脏和胸腺中免疫细胞的百分率,酶联免疫吸附测定(ELISA)检测血清中细胞因子的含量。结果人参皂苷Rh2可缓解小鼠放疗和甲氨蝶呤导致的体质量下降。与模型对照组比较,Rh2能增加脾脏、胸腺淋巴细胞中CD_4^+T细胞和CD_8^+T细胞的数量(P<0.05或P<0.01),增加脾脏中自然杀伤细胞(NK)的数量,提高T细胞受体(TCR)的表达(P<0.05或P<0.01),减少脾脏中髓来源的抑制性细胞(MDSC)的数量(P<0.05或P<0.01),提高树突状细胞(DCs)表面共刺激分子MHCII的表达(P<0.05),降低DCs表面负性调控分子:程序性死亡分子1配体(PD-L1)的表达(P<0.05),促进血清中Th1型细胞因子白细胞介素2(IL-2)和肿瘤坏死因子α(TNF-α)的分泌(P<0.05或P<0.01)。结论人参皂苷Rh2能缓解小鼠放疗以及免疫抑制剂所致的免疫低下状态,该作用与促进天然免疫细胞分化成熟以及免疫效应细胞的增殖,提高Th1型细胞因子的分泌水平,增强免疫功能有关。 展开更多
关键词 人参皂苷RH2 甲氨蝶呤 放射治疗 免疫调节
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内镜黏膜下剥离术治疗老年人大肠侧向发育型肿瘤的初步研究 被引量:12
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作者 李红平 周光群 +7 位作者 刘雪梅 谢睿 狄连君 王海波 刘黔 周晏因 赵逵 庹必光 《中国内镜杂志》 2018年第11期56-61,共6页
目的回顾性对比分析老年人与中青年人大肠侧向发育型肿瘤(LST)的临床病理特点,探讨内镜黏膜下剥离术(ESD)对老年人大肠侧向发育型肿瘤的治疗效果。方法选取2011年9月-2016年9月在外院及该院检查发现,并在该院拟行ESD的LST患者,其中老年... 目的回顾性对比分析老年人与中青年人大肠侧向发育型肿瘤(LST)的临床病理特点,探讨内镜黏膜下剥离术(ESD)对老年人大肠侧向发育型肿瘤的治疗效果。方法选取2011年9月-2016年9月在外院及该院检查发现,并在该院拟行ESD的LST患者,其中老年组(≥60岁)53例,中青年组(30~59岁)37例,比较老年组和中青年组的性别、病变形态分型、病变部位、病理类型、手术方法、平均住院时间及术后并发症等情况。结果病变形态分型,老年人以结节混合型(LST-G-M)为主,与中青年组比较,差异有统计学意义(P <0.05);中青年组以平坦隆起型(LST-NG-F)为主,与老年组比较,差异有统计学意义(P <0.05);两组pit pattern分型,老年人以Ⅲ_L型、Ⅳ型为主,青年组以Ⅱ型、Ⅲ_L型为主,Ⅱ型两组比较,差异有统计学意义(P <0.05);两组患者病变好发于直肠,尤其以老年组明显,与中青年组比较差异有统计学意义(P <0.05),其次是升结肠,其余均少见,左半结肠的发病率高于右半结肠;病理情况,老年组以管状绒毛状腺瘤为主,容易伴局部癌变,与中青年组比较差异有统计学意义(P <0.05)。结论老年人LST是大肠癌发病的高危人群,若老年人检查发现LST,排除手术禁忌后应及时行内镜下切除;ESD是治疗大肠LST的重要手段,尤其适合老年人LST的治疗,值得临床运用与推广。 展开更多
关键词 内镜黏膜下剥离术 老年人 大肠侧向发育型肿瘤
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放疗联合高强度聚焦超声治疗胰腺癌的研究 被引量:8
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作者 施琦 马士杰 +3 位作者 周传文 谢睿 李苗苗 沈鹏 《中国现代医学杂志》 CAS 2020年第7期59-63,共5页
目的探讨放疗联合高强度聚焦超声治疗胰腺癌的疗效。方法将南京医科大学附属淮安第一医院收治的100例中晚期胰腺癌患者随机分为观察组及对照组,每组50例。对照组采用放疗,观察组在对照组的基础上联合高强度聚焦超声治疗;治疗前后检测患... 目的探讨放疗联合高强度聚焦超声治疗胰腺癌的疗效。方法将南京医科大学附属淮安第一医院收治的100例中晚期胰腺癌患者随机分为观察组及对照组,每组50例。对照组采用放疗,观察组在对照组的基础上联合高强度聚焦超声治疗;治疗前后检测患者血清学指标、影像学指标,观察临床症状及不良反应。结果治疗后两组患者血清糖类抗原199(CA199)、糖类抗原242(CA242)、骨桥蛋白(OPN)、中性粒细胞明胶酶相关运载蛋白(NGAL)及视黄醇结合蛋白4(RBP4)水平比较,差异有统计学意义(P<0.05),观察组低于对照组。两组患者血清谷丙转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、血尿素氮(BUN)及肌酐(Cr)水平比较,差异有统计学意义(P<0.05),观察组低于对照组。两组治疗前后血清中DJ-1及microRNA-155(miR-155)比较,差异有统计学意义(P<0.05)。治疗后两组患者血清DJ-1及miR-155水平均有所降低,且治疗后观察组低于对照组。观察组患者回声均有不同程度增强,其中5例肿瘤组织内出现小的无回声区。对照组患者回声未出现明显增强。观察组患者疼痛完全缓解率为89%(41/46),对照组患者疼痛程度无明显缓解。观察组患者食欲均出现不同程度的改善,体重均出现不同程度的增加,对照组患者饮食及体重无明显改变。治疗后,观察组平均体重重于对照组(P<0.05)。结论采用调强放疗联合高强度聚焦超声治疗胰腺癌后可有效提高临床疗效,并降低患者血清DJ-1及miR-155水平。 展开更多
关键词 胰腺肿瘤 螺旋断层调强放疗 高强度聚焦超声 DJ-1 microRNA-155
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TRPV6对结肠癌SW480细胞生物学行为及小鼠模型中结肠肿瘤发生的影响 被引量:3
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作者 谢臣武 刘模荣 +4 位作者 董辉 徐靖宇 谢睿 文国荣 刘莲花 《中国肿瘤临床》 CAS CSCD 北大核心 2018年第21期1079-1085,共7页
目的:通过观察沉默瞬时受体阳离子通道亚家族V成员6(transient receptor potential cation channel,subfamily V member 6,TRPV6)对结肠癌SW480细胞生物学行为的影响和细胞内钙的浓度变化,以及1,25(OH)_2D_3、CaCl_2及CuCl_2在SD大鼠结... 目的:通过观察沉默瞬时受体阳离子通道亚家族V成员6(transient receptor potential cation channel,subfamily V member 6,TRPV6)对结肠癌SW480细胞生物学行为的影响和细胞内钙的浓度变化,以及1,25(OH)_2D_3、CaCl_2及CuCl_2在SD大鼠结肠肿瘤模型建立中的影响,探索TRPV6在结肠癌发生过程中的相关作用,为结肠癌的防治寻找新的靶点。方法:通过构建慢病毒颗粒感染结肠癌SW480细胞,采用免疫组织化学法、Western bolt、PCR技术检测TRPV6蛋白及m RNA的表达,MTT法、迁移及凋亡实验观察结肠癌SW480细胞增殖、迁移及凋亡变化,高速离子成像系统测定结肠癌SW480细胞内的Ca^(2+)浓度变化。以二甲基肼(dimethyl hydrazine,DMH)建立SD大鼠结肠肿瘤模型,分为实验组(DMH组)和干预组[(DMH+1,25(OH)_2D_3组、DMH+CuCl_2组)]、对照组,干预组分别予1,25(OH)_2D_3(37.5 nmol/kg)、CuCl2(375μmol/kg)对模型进行干预。观察各组大鼠结肠腺瘤及腺癌的发生情况,Western blot检测各组结肠组织中TRPV6蛋白的表达情况。结果:TRPV6-RNAi转染结肠癌SW480细胞后,TRPV6 m RNA及蛋白表达减少,细胞Ca^(2+)浓度水平降低,结肠癌SW480细胞的增殖率、迁移能力下降,细胞凋亡率增加,与空白对照组及阴性对照组比较差异具有统计学意义(P<0.05)。对照组大鼠成瘤率为0,DMH+1,25(OH)_2D_3组为100%,DMH组为84.62%,DMH+CuCl_2组为33.33%。各组大鼠大肠中均有TRPV6蛋白的表达,表达情况为DMH+1,25(OH)_2D_3组>DMH组>DMH+CuCl_2组>对照组,差异具有统计学意义(P<0.05)。结论:降低结肠癌SW480细胞Ca^(2+)浓度水平可抑制结肠癌SW480细胞的增殖、迁移能力,诱导细胞凋亡。1,25(OH)_2D_3可以增加实验鼠结肠组织TRPV6蛋白表达,促进结肠肿瘤的形成。CuCl_2可以使实验鼠结肠组织中的TRPV6蛋白表达降低,并抑制结肠肿瘤的形成。 展开更多
关键词 TRPV6 基因沉默 钙离子通道 结肠癌 二甲基肼
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针尖载药可溶性聚合物微针的制备及释药性能 被引量:3
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作者 李新娇 巨晓洁 +3 位作者 谢锐 汪伟 刘壮 褚良银 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2021年第9期124-132,140,共10页
可溶性聚合物微针是一种新型经皮给药系统,受到医药领域的广泛关注。皮肤弹性会导致微针刺入不完全造成药物浪费。为了解决这一问题,文中通过优化微针溶液配方和制备工艺,采用分步浇注法制备了针尖载药可溶性聚合物微针,提高了给药效率... 可溶性聚合物微针是一种新型经皮给药系统,受到医药领域的广泛关注。皮肤弹性会导致微针刺入不完全造成药物浪费。为了解决这一问题,文中通过优化微针溶液配方和制备工艺,采用分步浇注法制备了针尖载药可溶性聚合物微针,提高了给药效率,并通过构建不同组成结构的聚合物微针实现了释药性能的调控。研究中选择具有生物相容性的聚合物材料,以磺酰罗丹明B为模型药物。结果表明,药物主要集中在微针针尖,占针体高度60%左右。所制备的针尖载药可溶性聚合物微针具有高力学强度和刺入皮肤能力,载药量稳定。体外释药结果表明,通过选择不同的聚合物材料,载药针尖可以实现快速溶解或缓慢溶胀,从而实现药物的快速释放或缓慢释放。文中提出的可溶性聚合物微针实现了针尖载药和释药性能调控,在经皮给药方面具有潜在的应用前景。 展开更多
关键词 微针 经皮给药 释药 可溶性聚合物
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具有油相隔离层的微流控法可控制备中空微纤维 被引量:2
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作者 谭昕玥 巨晓洁 +3 位作者 谢锐 汪伟 刘壮 褚良银 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2022年第3期1-9,17,共10页
利用具有油相隔离层的微流控法连续可控制备了海藻酸钙(CaAlg)中空微纤维。内外相流体通过微流控装置出口挤出,通过调整装置出口与凝固浴液面距离、外相流速和收集速度在油相隔离层中形成同轴射流,射流突破油水相界面进入凝固浴后交联形... 利用具有油相隔离层的微流控法连续可控制备了海藻酸钙(CaAlg)中空微纤维。内外相流体通过微流控装置出口挤出,通过调整装置出口与凝固浴液面距离、外相流速和收集速度在油相隔离层中形成同轴射流,射流突破油水相界面进入凝固浴后交联形成CaAlg中空纤维。实验中,微流控装置出口与凝固浴液面的最优距离为2 mm,外相流速越大,收集速度越小,射流越稳定。在形成稳定射流的条件范围内,制备得到了结构均一的CaAlg中空纤维,通过调整内外相流速和收集速度可以精确调控中空纤维的直径。根据流动连续性方程建立了简单的分析模型用于中空纤维直径的预测,该模型给出了内相流速、外相流速、收集速度与纤维直径的显式关系,并根据实验数据验证了模型预测的准确性。 展开更多
关键词 微流控 油相隔离层 海藻酸钙 中空纤维
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Role of gut microbiota via the gut-liver-brain axis in digestive diseases 被引量:21
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作者 Jian-Hong Ding Zhe Jin +7 位作者 Xiao-Xu Yang Jun Lou Wei-Xi Shan Yan-Xia Hu Qian Du Qiu-Shi Liao rui xie Jing-Yu Xu 《World Journal of Gastroenterology》 SCIE CAS 2020年第40期6141-6162,共22页
The gut-brain axis is a bidirectional information interaction system between the central nervous system(CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex... The gut-brain axis is a bidirectional information interaction system between the central nervous system(CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and neuroimmunity of the CNS, which is called the microbiota-gut-brain axis. Due to the close anatomical and functional interaction of the gut-liver axis, the microbiota-gut-liver-brain axis has attracted increased attention in recent years. The microbiota-gut-liver-brain axis mediates the occurrence and development of many diseases, and it offers a direction for the research of disease treatment. In this review, we mainly discuss the role of the gut microbiota in the irritable bowel syndrome, inflammatory bowel disease, functional dyspepsia, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatic encephalopathy via the gut-liver-brain axis, and the focus is to clarify the potential mechanisms and treatment of digestive diseases based on the further understanding of the microbiota-gut-liver-brain axis. 展开更多
关键词 Microbiota-gut-brain axis Gut-liver axis Gut microbiota Digestive diseases Herbaceous medications
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具有钾离子和谷胱甘肽双重响应特性的树状大分子药物载体的制备与控释性能
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作者 张璐 刘玉琼 +4 位作者 巨晓洁 谢锐 汪伟 刘壮 褚良银 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2022年第2期131-139,146,共10页
文中制备了一种具有钾离子(K^(+))和谷胱甘肽(GSH)双重响应性的树状大分子作为抗癌药物纳米载体。将具有K^(+)响应性的聚(N-异丙基丙烯酰胺-共聚-苯并-18-冠-6-丙烯酰胺)高分子(PNB)和末端带叶酸(FA)的聚乙二醇高分子(FA-PEG-SH)先后接... 文中制备了一种具有钾离子(K^(+))和谷胱甘肽(GSH)双重响应性的树状大分子作为抗癌药物纳米载体。将具有K^(+)响应性的聚(N-异丙基丙烯酰胺-共聚-苯并-18-冠-6-丙烯酰胺)高分子(PNB)和末端带叶酸(FA)的聚乙二醇高分子(FA-PEG-SH)先后接枝到聚酰胺-胺树状大分子(PAMAM)表面,制备得到多功能树状大分子PAMAM-g-PNB-ss-PEG-FA。该树状大分子具有明显的K^(+)响应性,37℃下表现出K^(+)诱导的分子构象转变,在K^(+)浓度5 mmol/L的溶液中呈现收缩状态,在K^(+)浓度150 mmol/L的溶液中呈现伸展状态。同时,PAMAM-g-PNB-ss-PEG-FA还具有明显的还原响应性,当从低浓度GSH溶液转换到高浓度GSH溶液时,二硫键断裂,PAMAM-g-PNB-ss-PEG-FA粒径显著减小。以疏水抗肿瘤药阿霉素(DOX)为模型药物,PAMAM-g-PNB-ss-PEG-FA树状大分子表现出明显的高浓度K^(+)和GSH诱导的释药行为。并且,PAMAM-g-PNB-ss-PEG-FA在一定浓度范围内对正常细胞及肿瘤细胞均无明显毒性。体外细胞实验证实,负载DOX的PAMAM-g-PNB-ss-PEG-FA能够被4T1细胞摄取,并且在肿瘤细胞内能响应胞内高浓度K^(+)和GSH而实现药物快速释放。 展开更多
关键词 K+响应性 谷胱甘肽响应性 树状大分子 靶向释放
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咪唑类离子液体中聚(N-异丙基丙烯酰胺)凝胶的体积相变行为
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作者 邓亚珍 刘壮 +3 位作者 巨晓洁 汪伟 谢锐 褚良银 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2021年第11期1-5,12,共6页
通过热引发的方法制备了聚(N-异丙基丙烯酰胺)(PNIPAM)水凝胶,对PNIPAM水凝胶进行真空冷冻干燥与溶剂置换后得到PNIPAM离子液体凝胶。通过扫描电镜(SEM)及温敏平衡体积溶胀实验分别表征了PNIPAM凝胶的微观结构和PNIPAM凝胶在真空干燥前... 通过热引发的方法制备了聚(N-异丙基丙烯酰胺)(PNIPAM)水凝胶,对PNIPAM水凝胶进行真空冷冻干燥与溶剂置换后得到PNIPAM离子液体凝胶。通过扫描电镜(SEM)及温敏平衡体积溶胀实验分别表征了PNIPAM凝胶的微观结构和PNIPAM凝胶在真空干燥前后的离子液体中体积相变行为。SEM结果表明,真空冷冻干燥后的PNIPAM凝胶具有大量微米级网络结构;温敏平衡体积溶胀实验表明,相同温度下PNIPAM离子液体凝胶的平衡体积随着离子液体阳离子上取代烷基的增长而增大,与真空干燥后的离子液体中的体积相变行为相比,在未真空干燥的离子液体中,PNIPAM离子液体凝胶在低温下的平衡体积显著减小、体积溶胀比增大。说明阳离子取代烷基链的增长有利于PNIPAM在离子液体中的溶胀,且水分对其体积相变行为有较大影响。 展开更多
关键词 聚(N-异丙基丙烯酰胺) 离子液体 体积相变 凝胶
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Absorption Characteristics of Novel Compound Calcium Carbonate Granules:Effects of Gastric Acid Deficiency and Exogenous Weak Acids 被引量:10
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作者 Hong-dan CHEN Yi-ping CHEN +3 位作者 rui xie Qin-yu HU Qi CHENG Ming XIANG 《Current Medical Science》 SCIE CAS 2019年第2期337-342,共6页
Calcium carbonates are commonly administered as supplements for conditions of calcium deficiency.We report here pharmacokinetic characteristics of a novel formulation,calcium carbonate compound granules(CCCGs).forming... Calcium carbonates are commonly administered as supplements for conditions of calcium deficiency.We report here pharmacokinetic characteristics of a novel formulation,calcium carbonate compound granules(CCCGs).forming complexes of calcium carbonate and calcium citrate in water.CCCGs were compared to a kind of commonly?used calcium carbonate preparation(CC)in the market in 5-week-old mice that had been treated with omeprazole,to suppress gastric acid secretion,and in untreated control mice.The results showed that:(1)CCCGs had better water solubility than CC in vitro;(2)In control mice,calcium absorption rates after CCCGs administration were comparable to those after CC administration;(3)Inhibition of gastric acid secretion did not affect calcium absorption after CCCGs,but moderately decreased it after CC;(4)The presence of phytic acid or tannin did not affect calcium absorption rates after CCCGs but did for CC;and(5)In nonnal mice,CCCGs did not inhibit gastric emptying and intestinal propulsion,and did not alter the gastrointestinal honnones.The results suggest that CCCGs may be therapeutically advantageous over more commonly used calcium supplement formulations,particularly for adolescents,because of their stable calcium absorption characteristics and their relatively favorable adverse effect profile. 展开更多
关键词 CALCIUM carbonate gastric ACID inhibition phytic ACID TANNIN CALCIUM absorption
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Graphene-based membranes for molecular and ionic separations in aqueous environments 被引量:8
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作者 Zhuang Liu Wei Wang +2 位作者 Xiaojie Ju rui xie Liangyin Chu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2017年第11期1598-1605,共8页
Graphene-based laminar materials open up to new applications for molecular and ionic separations in aqueous environments due to the atomic thickness, mechanical strength, chemical stability and other fantastic propert... Graphene-based laminar materials open up to new applications for molecular and ionic separations in aqueous environments due to the atomic thickness, mechanical strength, chemical stability and other fantastic properties.Recent advances on controlling the structure and chemical functionality of graphene-based membranes can potentially lead to new classes of tools for desalination, dehydration, toxicant rejection, specific ionic separation and so on. The recent developments of graphene-based membranes prepared by using a concept to form interlayer space between graphene sheets and creating nanoscale or sub-nanoscale pores in a graphene lattice, together with their mass-transfer mechanisms and potential applications in aqueous environments are reviewed. A summary and outlook is further provided on the opportunities and challenges in this arising field.This article is expected to address the intricate details of mass transport through two distinct graphene-based membranes in aqueous environment and to optimize the fabrication of graphene-based membranes as a fascinating separation system for a wide range of applications. 展开更多
关键词 GRAPHENE membranesTwo-dimensional materialsSeparationWater treatmentDesalinationion SELECTIVITY
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Neurofibromatosis type 1-associated multiple rectal neuroendocrine tumors: A case report and review of the literature 被引量:4
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作者 rui xie Kuang-I Fu +2 位作者 Shao-Min Chen Bi-Guang Tuo Hui-ChaoWu 《World Journal of Gastroenterology》 SCIE CAS 2018年第33期3806-3812,共7页
Neurofibromatosis type 1(NF-1) is commonly associated with benign or malignant tumors in both the central and peripheral nervous systems. However, rare cases of NF-1-associated multiplerectal neuroendocrine tumors hav... Neurofibromatosis type 1(NF-1) is commonly associated with benign or malignant tumors in both the central and peripheral nervous systems. However, rare cases of NF-1-associated multiplerectal neuroendocrine tumors have been reported. This report describes a case of a 39 year old female with NF-1 and intermittent hematochezia as a primary symptom. Physical examination showed multiple subcutaneous nodules and café au lait spots with obvious scoliosis of the back. Imaging examinations and colonoscopy found malformation of the left external iliac vein and multiple gray-yellow nodules with varying sizes and shapes in the rectal submucosal layer. Histological and immunohistochemical results suggested multiple rectal neuroendocrine tumors, a rare disease with few appreciable symptoms and a particularly poor prognosis. The patient with NF-1 presented here had not only multiple rectal neuroendocrine neoplasms but also vascular malformations, scoliosis and other multiple system lesions. This case therefore contributes to improving clinical understanding, diagnosis and treatment of related complications for patients with NF-1 who present with associated medical conditions. 展开更多
关键词 NEUROFIBROMATOSIS type 1 MULTIPLE RECTAL NEUROENDOCRINE tumors Vascular MALFORMATIONS SCOLIOSIS
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Roles of Na^+/Ca^(2+) exchanger 1 in digestive system physiology and pathophysiology 被引量:3
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作者 Qiu-Shi Liao Qian Du +2 位作者 Jun Lou Jing-Yu Xu rui xie 《World Journal of Gastroenterology》 SCIE CAS 2019年第3期287-298,共12页
The Na^+/Ca^(2+) exchanger(NCX) protein family is a part of the cation/Ca^(2+) exchanger superfamily and participates in the regulation of cellular Ca^(2+) homeostasis. NCX1, the most important subtype in the NCX fami... The Na^+/Ca^(2+) exchanger(NCX) protein family is a part of the cation/Ca^(2+) exchanger superfamily and participates in the regulation of cellular Ca^(2+) homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. In the past few years, the function of NCX1 in the digestive system has received increasing attention; NCX1 not only participates in the healing process of gastric ulcer and gastric mucosal injury but also mediates the development of digestive cancer, acute pancreatitis, and intestinal absorption.This review aims to explore the roles of NCX1 in digestive system physiology and pathophysiology in order to guide clinical treatments. 展开更多
关键词 Na^+/Ca^2+exchanger DIGESTIVE system diseases Ion channel Sodium Calcium
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Cholecystectomy does not significantly increase the risk of fatty liver disease 被引量:3
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作者 Hong-Gang Wang Li-Zhen Wang +6 位作者 Hang-Jiang Fu Peng Shen Xiao-Dan Huang Fa-Ming Zhang rui xie Xiao-Zhong Yang Guo-Zhong Ji 《World Journal of Gastroenterology》 SCIE CAS 2015年第12期3614-3618,共5页
AIM: To investigate the relationship between cholecystectomy and fatty liver disease(FLD) in a Chinese population.METHODS: A total of 32428 subjects who had voluntarily undergone annual health checkups in the Second A... AIM: To investigate the relationship between cholecystectomy and fatty liver disease(FLD) in a Chinese population.METHODS: A total of 32428 subjects who had voluntarily undergone annual health checkups in the Second Affiliated Hospital of Nanjing Medical University from January 2011 to May 2013 were included in this study. Basic data collection, physical examination, laboratory examination, and abdominal ultrasound examination were performed.RESULTS: Subjects undergoing cholecystectomy were associated with greater age, female sex, higher body mass index, and higher levels of systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, and triglycerides. However, no significant differences were found in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, gammaglutamyl transpeptidase, albumin, and serum uric acid. The overall prevalence of FLD diagnosed by ultrasonography was high at 38.4%. The prevalence of FLD was significantly higher for subjects who had undergone cholecystectomy(46.9%) than those who had not undergone cholecystectomy(38.1%; χ2 test, P < 0.001). Cholecystectomy was positively associated with FLD(OR = 1.433, 95%CI: 1.259-1.631). However, after adjusting for possible factors associated withFLD, multivariate regression analysis showed that the association between cholecystectomy and FLD was not statistically significant(OR = 1.096; 95%CI: 0.939-1.279). CONCLUSION: According to our study results, cholecystectomy may not be a significant risk factor for FLD. 展开更多
关键词 CHOLECYSTECTOMY FATTY LIVER DISEASE Relationship C
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State-of-the-art review of MPPT techniques for hybrid PV-TEG systems:modeling,methodologies,and perspectives 被引量:4
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作者 Bo Yang rui xie +1 位作者 Jinhang Duan Jingbo Wang 《Global Energy Interconnection》 EI CSCD 2023年第5期567-591,共25页
The development of alternative renewable energy technologies is crucial for alleviating climate change and promoting energy transformation.Of the currently available technologies,solar energy has promising application... The development of alternative renewable energy technologies is crucial for alleviating climate change and promoting energy transformation.Of the currently available technologies,solar energy has promising application prospects owing to its merits of being clean,safe,and sustainable.Solar energy is converted into electricity through photovoltaic(PV)cells;however,the overall conversion efficiency of PV modules is relatively low,and most of the captured solar energy is dissipated in the form of heat.This not only reduces the power generation efficiency of solar cells but may also have a negative impact on the electrical parameters of PV modules and the service life of PV cells.To overcome the shortcomings,an efficient approach involves combining a PV cell with a thermoelectric generator(TEG)to form hybrid PV-TEG systems,which simultaneously improve the energy conversion efficiency of the PV system by reducing the operating temperature of the PV modules and increasing the power output by utilizing the waste heat generated from the PV system to generate electricity via the TEGs.Based on a thorough examination of the literature,this study comprehensively reviews 14 maximum power point tracking(MPPT)algorithms currently applied to hybrid PV-TEG systems and classifies them into five major categories for further discussion,namely conventional,mathematics-based,metaheuristic,artificial intelligence,and other algorithms.This review aims to inspire advanced ideas and research on MPPT algorithms for hybrid PV-TEG systems. 展开更多
关键词 Photovoltaic Thermoelectric generator Hybrid PV-TEG MPPT Partial shading condition
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Simulation of drop breakage in liquid–liquid system by coupling of CFD and PBM: Comparison of breakage kernels and effects of agitator configurations 被引量:2
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作者 rui xie Jun Li +2 位作者 Yang Jin Da Zou Ming Chen 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2019年第5期1001-1014,共14页
This work focuses on drop breakage for liquid-liquid system with an adoption of numerical simulation by using computational fluid dynamics and population balance model (PBM) coupled with two-fluid model (TFM). Two dif... This work focuses on drop breakage for liquid-liquid system with an adoption of numerical simulation by using computational fluid dynamics and population balance model (PBM) coupled with two-fluid model (TFM). Two different breakage kernels based on identical breakage mechanism but different descriptions of breaking time are take n into account in this work. Eight cases corresp on ding to distinct configurations of agitator are carried out to validate numerical predictions, namely agitators with different porosity and hole diameters, respectively implemented in Cases 1 to 5 and Cases 6 to 8. The results are compared with experimental data for testing the applicability of both kernels. Simulations are implemented, in this work, with an approach of class method for the solution of population balance model by the special-purpose computational fluid dynamics solver Fluent 16.1 based on finite volume method, and the grids used for meshing the solution domain are accomplished in a commercial software Gambit 2.4.6. The effects of configurations of agitator corresponding to different parameters mentioned above on final Sauter mean diameter are equally concentrated in this work. Analysis of both kernels and comparisons with experimental results reveal that, the second kernel has more decent agreement with experiments, and the results of investigations on effects of agitator configurations show that the in fluences of these parameters on Sauter mean diameter are marginal, but appropriate porosity and hole diameter are actually able to decrease Sauter mean diameter. These outcomes allow us to draw general conclusions and help investigate performances of liquid-liquid system. 展开更多
关键词 Stirred vessel LIQUID-LIQUID system Computational fluid dynamics Population balance model BREAKAGE kernel AGITATOR configuration
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Unexplained abdominal pain due to a fish bone penetrating the gastric antrum and migrating into the neck of the pancreas: A case report 被引量:2
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作者 rui xie Bi-Guang Tuo Hui-Chao Wu 《World Journal of Clinical Cases》 SCIE 2019年第6期805-808,共4页
BACKGROUND Ingestion of foreign bodies results in gastrointestinal perforation in approximately 1% of patients,and fish bones are the objects that most commonly lead to bowel perforation. When it does occur,the termin... BACKGROUND Ingestion of foreign bodies results in gastrointestinal perforation in approximately 1% of patients,and fish bones are the objects that most commonly lead to bowel perforation. When it does occur,the terminal ileum is the most common site of perforation,followed by the duodenal C-loop. However,involvement of the pancreas is very rare. Because clinical symptoms are nonspecific and gastrointestinal perforation may present as only odynophagia or abdominal pain,a definite preoperative diagnosis and clinical intervention may be delayed.CASE SUMMARY We report the case of a 32-year-old man who presented to our hospital because of abdominal pain that had worsened over 5 d. He had no significant past history except that he had eaten fish 1 wk previously. Upper endoscopy revealed an irregular submucosal tumor on the front wall of the gastric antrum. Endoscopic ultrasonography and computed tomography showed a fish bone penetrating the gastric antrum and migratingin to the neck of the pancreas. The patient underwent laparoscopic surgery and had no complications one week after the operation.CONCLUSION A recent history of foreign body ingestion and imaging examinations are helpful for diagnosis of unexplained abdominal pain caused by foreign bodies. 展开更多
关键词 UNEXPLAINED ABDOMINAL pain Fish bone Gastrointestinal PERFORATION PANCREAS Case report
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