心电向量图诊断高血压早期心脏靶器官损害的临床应用及影响因素

目的探讨心电向量图(vectorcardiogram,VCG)对高血压心脏电活动异常的诊断价值,并分析早期心脏靶器官损害的影响因素。方法选取昆明市中医医院心血管病科2022年1月至2023年2月的高血压病住院患者80例,经超声心动图(ultrasound cardiogram,UCG)排外心脏结构异常。比较心电图(electrocardiogram,ECG)与VCG对异常心室除极与复极指标的检出情况。按心电向量检查结果将80例病例分为正常组(n=40)与异常组(n=40),比较2组早期心脏损害的相关影响因素指标,将差异有统计学意义的因素做二元Logistic回归分析,筛选出早期心脏损害的独立影响因素。结果VCG检出异常心室复极指标较ECG有优势(P<0.05),二者对异常除极指标的检出差异无统计学意义(P>0.05)。正常组与异常组比较,在年龄、规律服药、家族史、糖尿病、24 h平均收缩压(24 h average systolic blood pressure,24 h SBP)、白昼平均收缩压(daytime average systolic blood pressure,DSBP)、夜间平均收缩压(night average systolic blood pressure,NSBP)、血压负荷值、清晨血压、脉压差等指标上,差异有统计学意义(P<0.05)。二元Logistic回归分析显示,年龄[OR(95%CI)=0.891,0.998]、夜间平均收缩压[OR(95%CI)=1.018,2.10]、家族史[OR(95%CI)=0.029,0.499]、糖尿病[OR(95%CI)=0.042,0.916]是高血压早期心脏损害的独立影响因素。结论VCG为高血压早期心脏靶器官损害的有效检测手段。

Review on analytical technologies and applications in metabolomics

Over the past decade,the swift advancement of metabolomics can be credited to significant progress in technologies such as mass spectrometry,nuclear magnetic resonance,and multivariate statistics.Currently,metabolomics garners widespread application across diverse fields including drug research and development,early disease detection,toxicology,food and nutrition science,biology,prescription,and chinmedomics,among others.Metabolomics serves as an effective characterization technique,offering insights into physiological process alterations in vivo.These changes may result from various exogenous factors like environmental conditions,stress,medications,as well as endogenous elements including genetic and protein-based influences.The potential scientific outcomes gleaned from these insights have catalyzed the formulation of innovative methods,poised to further broaden the scope of this domain.Today,metabolomics has evolved into a valuable and widely accepted instrument in the life sciences.However,comprehensive reviews focusing on the sample preparation and analytical methodologies employed in metabolomics within the life sciences are surprisingly scant.This review aims to fill that gap,providing an overview of current trends and recent advancements in metabolomics.Particular emphasis is placed on sample preparation,sophisticated analytical techniques,and their applications in life science research.

瓯江口凤鲚鱼卵、仔稚鱼的时空分布及其与环境因子关系

为了解凤鲚(Coilia mystus)早期群体在瓯江口的时空分布及其影响因素,研究根据瓯江口渔业资源调查数据,利用两阶段广义加性模型(Two-stage GAM)分析影响凤鲚鱼卵仔稚鱼分布的环境因子。采用交叉验证评价模型的预测性能,对2020年5-7月的凤鲚鱼卵、仔稚鱼出现率及资源量进行预测。结果表明:5-7月是瓯江口凤鲚的主要繁殖期,鱼卵主要分布在瓯江上游七都岛附近低盐水域,仔稚鱼在瓯江水域均有分布,瓯江下游灵昆岛近岸水域仔稚鱼的相对资源丰度高于瓯江上游。GAM模型分析表温、表盐是影响凤鲚早期群体分布的主要环境因子,表盐对鱼卵的分布具有极显著影响(P<0.01),适宜表盐在1以下,适宜表温在24-26℃;仔稚鱼对水温、盐度的适宜度宽于鱼卵,表温对仔稚鱼的分布具有显著影响(P<0.05),适宜表温为22-27℃,适宜表盐为5-13。交叉验证分析认为模型对鱼卵的预测性能(AUC均值0.83)优于仔稚鱼(AUC均值0.71)。2020年预测结果显示,凤鲚鱼卵的适宜栖息环境较窄,主要集中在江心屿上游及灵昆岛下游附近水域,仔稚鱼主要栖息在江心屿至灵昆岛水域。瓯江口作为凤鲚的主要栖息场所之一,掌握凤鲚早期群体在瓯江口的分布特征及与环境因子间的关系,能够为其产卵场栖息地的保护和资源养护管理提供科学依据。

瓯江口凤鲚生长、死亡和最适开捕体长

根据2015、2018—2020年瓯江口水域渔业资源监测调查资料,对1359尾凤鲚的体长、全长和体重等生物学信息进行测定,利用体长频率分布估算凤鲚种群生长、死亡参数等。结果表明,瓯江口凤鲚体长为5.2—21.9 cm;体长和体重的关系式W=0.0035×L^(3.0783)。用ELEFAN技术拟合的von Bertalanffy生长方程的各参数为L_(∞)=26.60 cm,k=0.47及t_(0)=–0.55 a;Z=2.30,M=1.00,F=1.30,E=0.567,表明资源处于过度开发状态;凤鲚的首次捕捞体长Lc=15.35 cm,对应首次捕捞平均年龄为1.28 a,小于临界年龄(1.36 a)和体重生长的拐点年龄(1.85 a),表明当前渔业主要捕捞对象为幼鱼和补充群体,无法保证资源的有效补充。在瓯江口凤鲚目前的资源状态下,应努力降低捕捞死亡率,并加强对凤鲚栖息环境的保护,而对目前以小型化和低龄化为主的凤鲚群体,以控制开捕体长为主,根据Beverton-Holt动态模型,建议开捕体长为15.50 cm,对应开捕年龄为1.31 a。

Forecasting method of monthly wind power generation based on climate model and long short-term memory neural network

Predicting wind power gen eration over the medium and long term is helpful for dispatchi ng departme nts,as it aids in constructing generation plans and electricity market transactions.This study presents a monthly wind power gen eration forecast!ng method based on a climate model and long short-term memory(LSTM)n eural n etwork.A non linear mappi ng model is established between the meteorological elements and wind power monthly utilization hours.After considering the meteorological data(as predicted for the future)and new installed capacity planning,the monthly wind power gen eration forecast results are output.A case study shows the effectiveness of the prediction method.

Cobalt-based multicomponent nanoparticles supported on N-doped graphene as advanced cathodic catalyst for zinc-air batteries

To improve the efficiency of cathodic oxygen reduction reaction(ORR)in zinc-air batteries(ZABs),an adsorption-complexation-calcination method was proposed to generate cobalt-based multicomponent nanoparticles comprising Co,Co_(3)O_(4)and CoN,as well as numerous N heteroatoms,on graphene nanosheets(Co/Co_(3)O_(4)/CoN/NG).The Co/Co_(3)O_(4)/CoN nanoparticles with the size of less than 50 nm are homogeneously dispersed on N-doped graphene(NG)substrate,which greatly improve the catalytic behaviors for ORR.The results show that the half-wave potential is as high as 0.80 V vs.RHE and the limiting current density is 4.60 mA·cm^(−2),which are close to those of commercially available platinum/carbon(Pt/C)catalysts.Applying as cathodic catalyst for ZABs,the battery shows large specific capacity and open circuit voltage of 843.0 mAh∙g^(−1) and 1.41 V,respectively.The excellent performance is attributed to the efficient two-dimensional structure with high accessible surface area and the numerous multiple active sites provided by highly scattered Co/Co_(3)O_(4)/CoN particles and doped nitrogen on the carbon matrix.

Advancing the pressure sensing performance of conductive CNT/PDMS composite film by constructing a hierarchical-structured surface

Flexible pressure sensors have attracted wide attention due to their applications to electronic skin,health monitoring,and human-machine interaction.However,the tradeoff between their high sensitivity and wide response range remains a challenge.Inspired by human skin,we select commercial silicon carbide sandpaper as a template to fabricate carbon nanotube(CNT)/polydimethylsiloxane(PDMS)composite film with a hierarchical structured surface(h-CNT/PDMS)through solution blending and blade coating and then assemble the h-CNT/PDMS composite film with interdigitated electrodes and polyurethane(PU)scotch tape to obtain an h-CNT/PDMS-based flexible pressure sensor.Based on in-situ optical images and finite element analysis,the significant compressive contact effect between the hierarchical structured surface of h-CNT/PDMS and the interdigitated electrode leads to enhanced pressure sensitivity and a wider response range(0.1661 kPa^(-1),0.4574 kPa^(-1)and 0.0989 kPa^(-1)in the pressure range of 0–18 kPa,18–133 kPa and 133–300 kPa)compared with planar CNT/PDMS composite film(0.0066 kPa^(-1)in the pressure range of 0–240 kPa).The prepared pressure sensor displays rapid response/recovery time,excellent stability,durability,and stable response to different loading modes(bending and torsion).In addition,our pressure sensor can be utilized to accurately monitor and discriminate various stimuli ranging from human motions to pressure magnitude and spatial distribution.This study supplies important guidance for the fabrication of flexible pressure sensors with superior sensing performance in next-generation wearable electronic devices.

Time-Critical Tasks Implementation in MEC Based Multi-Robot Cooperation Systems

Mobile edge computing(MEC) deployment in a multi-robot cooperation(MRC) system is an effective way to accomplish the tasks in terms of energy consumption and implementation latency. However, the computation and communication resources need to be considered jointly to fully exploit the advantages brought by the MEC technology. In this paper, the scenario where multi robots cooperate to accomplish the time-critical tasks is studied, where an intelligent master robot(MR) acts as an edge server to provide services to multiple slave robots(SRs) and the SRs are responsible for the environment sensing and data collection. To save energy and prolong the function time of the system, two schemes are proposed to optimize the computation and communication resources, respectively. In the first scheme, the energy consumption of SRs is minimized and balanced while guaranteeing that the tasks are accomplished under a time constraint. In the second scheme, not only the energy consumption, but also the remaining energies of the SRs are considered to enhance the robustness of the system. Through the analysis and numerical simulations, we demonstrate that even though the first policy may guarantee the minimization on the total SRs’ energy consumption, the function time of MRC system by the second scheme is longer than that by the first one.

Five-year follow-up of 263 cases of functional bowel disorder

AIM: To determine the mortality associated with functional bowel disorders (FBDs) and their possible relationship with organic bowel disease. METHODS: Patients who satisfied the Rome Ⅲ criteria for FBD (retrospective diagnosis) were followed up by telephone interview and/or outpatient review at 5 years after their first attendance. The patients were divided into the following groups: irritable bowel syndrome, functional abdominal bloating, functional constipation, functional diarrhea and unspecified FBD. The survival of the FBD patients overall and of those with each FBD were compared with data obtained from the Guangzhou population in 2005. The incidences of colonic cancer overall and for each FBD were compared with data from the Chinese population obtained from 56 cancer registries in 19 provinces of the country in 2008. RESULTS: Two hundred and sixty-three patients were followed-up. Five patients died, which was not significantly different from the expected survival rate. No differences in mortality among the FBDs were found. There were nine cases of organic bowel disease: three colonic cancers and six colonic polyps. The incidence of colonic cancer in FBD patients was higher than that in the general Chinese population (0.23% vs 0.03%, P < 0.05). There were significant differences in the incidence of colonic cancer among the FBDs (0/134, 0/24, 2/29, 1/66, 0/10, respectively, P<0.05); functional constipation was the most common. The incidence of colonic polyps was similar among the FBDs. The baseline age of patients who died was greater than that of those who survived (66.60±6.84 years vs 45.14±10.34 years, P<0.05). The baseline age of patients who had colonic cancer or polyps during follow-up was greater than that of those without colonic cancer or polyps (60.33±1.53 years vs 45.38±10.62 years; 54.50±6.47 years vs 45.34±10.68 years, P<0.05). CONCLUSION: FBDs do not increase the risk of death. The incidence of colonic cancer in patients with FBDs may be increased, especially in those with functional constipation and in the elderly.

Immediate and legacy effects of snow exclusion on soil fungal diversity and community composition

Background:Soil fungi play crucial roles in ecosystem functions.However,how snow cover change associated with winter warming affects soil fungal communities remains unclear in the Tibetan forest.Methods:We conducted a snow manipulation experiment to explore immediate and legacy effects of snow exclusion on soil fungal community diversity and composition in a spruce forest on the eastern Tibetan Plateau.Soil fungal communities were performed by the high throughput sequencing of gene-fragments.Results:Ascomycota and Basidiomycota were the two dominant fungal phyla and Archaeorhizomyces,Aspergillus and Amanita were the three most common genera across seasons and snow manipulations.Snow exclusion did not affect the diversity and structure of soil fungal community in both snow-covered and snow-free seasons.However,the relative abundance of some fungal communities was different among seasons.Soil fungal groups were correlated with environmental factors(i.e.,temperature and moisture)and soil biochemical variables(i.e.,ammonium and enzyme).Conclusions:These results suggest that the season-driven variations had stronger impacts on soil fungal community than short-term snow cover change.Such findings may have important implications for soil microbial processes in Tibetan forests experiencing significant decreases in snowfall.

Review on microbial metabolomics of probiotics and pathogens:Methodologies and applications

In recent years,microbial metabolomics,a new field that has attracted wide attention,provides a map of metabolic pathways and clarifies the interaction mechanism between microorganisms and hosts.Many microorganisms are found in the human intestine,oral cavity,vagina,etc.Probiotics could maintain the good health of the host,while pathogens and an imbalance of bacterial flora lead to a series of diseases of the body and mind.Metabolomics is a science for qualitative and quantitative analysis of all metabolites in an organism or biological system,which could provide key information to understand the related metabolic pathways and associated changes.This approach analyzes the final products of cellular regulatory processes,the level of which can be regarded as the ultimate response of the biological system to genetic or environmental changes.Microbial metabolomics has been widely used in different research fields,such as microbial phenotypic classification,mutant screening,metabolic pathways,microbial metabolic engineering,fermentation engineering monitoring and optimization,microbial environmental pollution,and so on.However,there are only a few reviews on microbial metabolomics of probiotics and pathogens.This review summarizes the main methodologies,including sample preparation,identification of metabolites,data processing,and analysis.Recent applications in microbial metabolomics of probiotics and pathogens are also described.This paper first summarized the research progress and application of microbial metabolomics from two aspects:probiotics and pathogenic bacteria.Probiotics and pathogenic bacteria do not exist independently most of the time;hence,these were reviewed in the research field of coexistence of probiotics and pathogenic bacteria,which was subdivided into important microbial research fields closely related to human health,including the human gut,oral cavity,food,and nutrition-related microorganisms.Then,the main problems and trends associated with microbial metabolomics are discussed.

Photovoltaic effects in reconfigurable heterostructured black phosphorus transistors

We demonstrate a reconfigurable black phosphorus electrical field transistor,which is van der Waals heterostructured with few-layer graphene and hexagonal boron nitride flakes.Varied homojunctions could be realized by controlling both source–drain and top-gate voltages.With the spatially resolved scanning photocurrent microscopy technique,photovoltaic photocurrents originated from the band-bending regions are observed,confirming nine different configurations for each set of fixed voltages.In addition,as a phototransistor,high responsivity(～800 mA/W)and fast response speed(～230μs)are obtained from the device.The reconfigurable van der Waals heterostructured transistors may offer a promising structure towards electrically tunable black phosphorus-based optoelectronic devices.

Medical imaging-based companion diagnostics for solid tumors

Heterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses.Companion diagnostics(CDx),a clinical technique that gives doctors vital biomarker information to enhance patient outcomes through matching specific treatments to patients,is becoming more and more important.However,most current US Food and Drug Administration(FDA)-approved CDx tests have difficulty dynamically reflecting variations in biomarkers in the solid tumor microenvironment because they are used in vitro and ex vivo.Consequently,new medical imaging-based CDx tests have been widely used to detect interpatient and intrapatient tumor heterogeneity to assess the intratumoral distribution of specific biomarkers and microenvironment variables.They provide patient stratification for targeted therapies and the differentiation of patient populations that benefit from alternative treatments.This review provides an overview of the recent advances in medical imaging-based CDx for solid tumors and summarizes the various tumor microenvironment biomarkers utilized in imaging-based CDx.We believe that this review offers additional details and directions for promoting medical imaging-based CDx development.

浙江中南部近岸海域春季主要鱼类空间生态位

基于2016年4、5月(春季)在浙江中南部近岸海域进行的2个航次渔业资源调查数据,计算浙江中南部近岸海域主要鱼类的相对重要性指数(IRI)、平均拥挤度、生态位宽度及生态位重叠值(Qik)。结果表明:浙江中南部近岸海域主要鱼类(IRI>100)共24种,生态位宽度值差异较大,相对重要性指数与生态位宽度值呈极显著正相关。春季鱼类的生态位重叠值极低,4月Qik>0.6的种对有6对,占总对数的3.9%;5月Qik>0.6的种对有5对,占总对数的4.8%。冗余分析表明,温度、盐度、深度和溶解氧是影响浙江中南部近岸海域主要鱼类分布的重要因素,主要鱼类在这些环境因子上存在生态分化现象。

大陈洋产卵场保护区甲壳类群落结构特征及其与环境因子的关系

为了解浙江省大陈洋产卵场保护区甲壳类的群落结构特征,于2018年春季(4月)和秋季(11月)对甲壳类生物资源进行了底拖网调查,应用相对重要性指数(IRI)、生物多样性指数和典范对应分析(CCA)等方法对其群落结构及其与环境因子的关系进行了综合分析。结果表明:共鉴定出甲壳类38种,隶属14科25属,其中口虾蛄、三疣梭子蟹、双斑蟳和哈氏仿对虾为优势种。春季甲壳类资源密度在50 m以浅海域较高;秋季在50 m以深海域较高,且保护区内南部甲壳类资源密度高于北部。关于多样性特征,春季甲壳类丰富度指数(D)、多样性指数(H)和均匀度指数(J)均高于秋季,空间分布上50 m以深海域甲壳类的H最高。根据生物量进行等级聚类分析(CLUSTER)和非度量多维标度排序(NMDS)分析,春季可将甲壳类划分为3个群落,秋季划分为4个群落,春季甲壳类群落结构组内差异性较秋季显著。典范对应分析结果表明,水深、底温、盐度和溶解氧为影响甲壳类种类组成和时空变化的主要环境因子。

Flexible conductive Ag nanowire/cellulose nano?bril hybrid nanopaper for strain and temperature sensing applications

With the rapid development of smart wearable devices, flexible and biodegradable sensors are in urgent needs. In this study, ‘‘green" electrically conductive Ag nanowire (Ag NW)/cellulose nanofiber (CNF) hybrid nanopaper was fabricated to prepare flexible sensors using the facial solution blending and vacuum filtration technique. The amphiphilic property of cellulose is beneficial for the homogeneous dispersion of Ag NW to construct effective electrically conductive networks. Two different types of strain sensors were designed to study their applications in strain sensing. One was the tensile strain sensor where the hybrid nanopaper was sandwiched between two thermoplastic polyurethane (TPU) films through hot compression, and special micro-crack structure was constructed through the pre-strain process to enhance the sensitivity. Interestingly, typical pre-strain dependent strain sensing behavior was observed due to different crack densities constructed under different pre-strains. As a result, it exhibited an ultralow detection limit as low as 0.2%, good reproducibility under different strains and excellent stability and durability during 500 cycles (1% strain, 0.5 mm/min). The other was the bending strain sensor where the hybrid nanopaper was adhered onto TPU film, showing stable and recoverable linearly sensing behavior towards two different bending modes (tension and compression). Importantly, the bending sensor displayed great potential for human motion and physiological signal detection. Furthermore, the hybrid nanopaper also exhibited stable and reproducible negative temperature sensing behavior when it was served as a temperature sensor. This study provides a guideline for fabricating flexible and biodegradable sensors.

强健超弹的蜘蛛网状聚酰亚胺纤维基导电复合气凝胶用于极端温度下的线性压力传感器

压力传感器是人工触觉感应的基石.尽管人们对高性能压力传感器进行了广泛的研究,但解决传感器的高灵敏度、宽线性响应范围和宽工作温度范围仍然面临巨大挑战.在此,我们创新性地应用三乙胺实现了疏水聚酰亚胺纤维(PIFs)在碳纳米管(CNT)水溶液中的均匀分散,同时纤维的结构不会受到破坏,并利用冻干和热酰亚胺化技术制备了强健超弹的蜘蛛网状(PIF/CNT)导电复合气凝胶.该气凝胶作为压力传感器具有宽线性感应范围(0.01-53.34 kPa)、超低检测限(10 Pa)、高灵敏度(0.507 kPa^(-1))、快速响应/恢复时间(85/80 ms)、稳定的快速压缩响应(500 mm min^(-1))和优异的抗循环疲劳能力(5000次)等优异的传感性能.有限元分析表明,多级纤维网络有利于相邻的导电纤维之间的接触面积在外部压力下有明显的线性变化,使之表现出优异的线性传感性能.该传感器可用于人体生理和运动信号检测、电子皮肤和智能控制,且在极端温度(-100-300℃)下表现出出色的传感稳定性和热绝缘性,可用于极端太空环境下太空服和月球/火星栖息地充气结构的传感单元.本工作为开发下一代线性压力传感器提供了一个简单有效的方法.

Photodynamic therapy accelerates skin wound healing through promoting re-epithelialization

Background:Epidermal stem cells(EpSCs)that reside in cutaneous hair follicles and the basal layer of the epidermis are indispensable for wound healing and skin homeostasis.Little is known about the effects of photochemical activation on EpSC differentiation,proliferation and migration during wound healing.The present study aimed to determine the effects of photodynamic therapy(PDT)on wound healing in vivo and in vitro.Methods:We created mouse full-thickness skin resection models and applied 5-aminolevulinic acid(ALA)for PDT to the wound beds.Wound healing was analysed by gross evaluation and haematoxylin–eosin staining in vivo.In cultured EpSCs,protein expression was measured using flow cytometry and immunohistochemistry.Cell migration was examined using a scratch model;apoptosis and differentiation were measured using flow cytometry.Results:PDT accelerated wound closure by enhancing EpSC differentiation,proliferation and migration,thereby promoting re-epithelialization and angiogenesis.PDT inhibited inflammatory infiltration and expression of proinflammatory cytokines,whereas the secretion of growth factors was greater than in other groups.The proportion of transient amplifying cells was significantly greater in vivo and in vitro in the PDT groups.EpSC migration was markedly enhanced after ALAinduced PDT.Conclusions:Topical ALA-induced PDT stimulates wound healing by enhancing re-epithelialization,promoting angiogenesis as well as modulating skin homeostasis.This work provides a preliminary theoretical foundation for the clinical administration of topical ALA-induced PDT in skin wound healing.

Nitrogen addition mediates the response of foliar stoichiometry to phosphorus addition: a meta-analysis

Background:Changes in foliar nitrogen(N)and phosphorus(P)stoichiometry play important roles in predicting the efects of global change on ecosystem structure and function.However,there is substantial debate on the efects of P addition on foliar N and P stoichiometry,particularly under diferent levels of N addition.Thus,we conducted a global meta-analysis to investigate how N addition alters the efects of P addition on foliar N and P stoichiometry across different rates and durations of P addition and plant growth types based on more than 1150 observations.Results:We found that P addition without N addition increased foliar N concentrations,whereas P addition with N addition had no efect.The positive efects of P addition on foliar P concentrations were greater without N addition than with N addition.Additionally,the efects of P addition on foliar N,P and N:P ratios varied with the rate and duration of P addition.In particular,short-term or low-dose P addition with and without N addition increased foliar N concentration,and the positive efects of short-term or low-dose P addition on foliar P concentrations were greater without N addition than with N addition.The responses of foliar N and P stoichiometry of evergreen plants to P addition were greater without N addition than with N addition.Moreover,regardless of N addition,soil P availability was more efective than P resorption efciency in predicting the changes in foliar N and P stoichiometry in response to P addition.Conclusions:Our results highlight that increasing N deposition might alter the response of foliar N and P stoichiometry to P addition and demonstrate the important efect of the experimental environment on the results.These results advance our understanding of the response of plant nutrient use efciency to P addition with increasing N deposition.

Macrophage LMO7 deficiency facilitates inflammatory injury via metabolic-epigenetic reprogramming

Inflammatory bowel disease(IBD)is a formidable disease due to its complex pathogenesis.Macrophages,as a major immune cell population in IBD,are crucial for gut homeostasis.However,it is still unveiled how macrophages modulate IBD.Here,we found that LIM domain only 7(LMO7)was downregulated in pro-inflammatory macrophages,and that LMO7 directly degraded 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(PFKFB3)through K48-mediated ubiquitination in macrophages.As an enzyme that regulates glycolysis,PFKFB3 degradation led to the glycolytic process inhibition in macrophages,which in turn inhibited macrophage activation and ultimately attenuated murine colitis.Moreover,we demonstrated that PFKFB3 was required for histone demethylase Jumonji domaincontaining protein 3(JMJD3)expression,thereby inhibiting the protein level of trimethylation of histone H3 on lysine 27(H3K27me3).Overall,our results indicated the LMO7/PFKFB3/JMJD3 axis is essential for modulating macrophage function and IBD pathogenesis.Targeting LMO7 or macrophage metabolism could potentially be an effective strategy for treating inflammatory diseases.