Objective:To summarize and analyze the effects of radiofrequency ablation (RFA) on patients' condition and quality of life after treatment of large liver cancer.Methods: A total of 51 patients with primary liver c...Objective:To summarize and analyze the effects of radiofrequency ablation (RFA) on patients' condition and quality of life after treatment of large liver cancer.Methods: A total of 51 patients with primary liver cancer with a diameter of 4-7 cm were selected from our hospital. The related tumor markers and liver function indexes were analyzed before and after treatment, and the patients' progression-free survival was analyzed with long-term follow-up.Results: On the 3rd day after the treatment, the AFP level of the patients was not significantly different from that before the treatment (P>0.05), and on the 7th day after the treatment, the AFP level was significantly lower than that before the treatment (P<0.05). The levels of CA199 and ferritin were slightly higher on the 3rd day after treatment than before treatment (P<0.05), and the levels of CA199 and ferritin were significantly lower on the 7th day after treatment than before treatment (P<0.05). The index of liver function at 3 days after treatment was slightly higher than that before treatment (P<0.05), and there was no significant difference in liver function at 7 d after treatment (P>0.05). Progression-free survival was observed at 1 month (90.2%), 38 at 3 months (74.5%), 33 at 6 months (64.7%), and 28 at 12 months (54.9%). After 1 month of treatment, the ECOG of 48 patients recovered to the pre-treatment level, with 3 cases of deterioration (including 2 deaths);After 3 months of treatment, there was no significant change in ECOG in 42 patients, and the ECOG score deteriorated in 9 patients (including 3 deaths). After 6 months of treatment, 36 cases of ECOG were unchanged, while 12 cases were deteriorated (including 5 deaths). After 12 months of treatment, 30 cases of ECOG were unchanged, with 21 cases of deterioration (including 9 deaths).Conclusion: Radiofrequency ablation can better alleviate the disease and improve the quality of life of patients with primary liver cancer with diameter of 4-7 cm. Further studies are needed to compare the effects of other local treatments.展开更多
文摘Objective:To summarize and analyze the effects of radiofrequency ablation (RFA) on patients' condition and quality of life after treatment of large liver cancer.Methods: A total of 51 patients with primary liver cancer with a diameter of 4-7 cm were selected from our hospital. The related tumor markers and liver function indexes were analyzed before and after treatment, and the patients' progression-free survival was analyzed with long-term follow-up.Results: On the 3rd day after the treatment, the AFP level of the patients was not significantly different from that before the treatment (P>0.05), and on the 7th day after the treatment, the AFP level was significantly lower than that before the treatment (P<0.05). The levels of CA199 and ferritin were slightly higher on the 3rd day after treatment than before treatment (P<0.05), and the levels of CA199 and ferritin were significantly lower on the 7th day after treatment than before treatment (P<0.05). The index of liver function at 3 days after treatment was slightly higher than that before treatment (P<0.05), and there was no significant difference in liver function at 7 d after treatment (P>0.05). Progression-free survival was observed at 1 month (90.2%), 38 at 3 months (74.5%), 33 at 6 months (64.7%), and 28 at 12 months (54.9%). After 1 month of treatment, the ECOG of 48 patients recovered to the pre-treatment level, with 3 cases of deterioration (including 2 deaths);After 3 months of treatment, there was no significant change in ECOG in 42 patients, and the ECOG score deteriorated in 9 patients (including 3 deaths). After 6 months of treatment, 36 cases of ECOG were unchanged, while 12 cases were deteriorated (including 5 deaths). After 12 months of treatment, 30 cases of ECOG were unchanged, with 21 cases of deterioration (including 9 deaths).Conclusion: Radiofrequency ablation can better alleviate the disease and improve the quality of life of patients with primary liver cancer with diameter of 4-7 cm. Further studies are needed to compare the effects of other local treatments.
