Dear Editor, Voltage-gated sodium （Nav） channels are membrane pro- teins that are responsible for the propagation of action potentials in mammals by mediating Na~ influx in excitable cells such as nerve and muscle. ...Dear Editor, Voltage-gated sodium （Nav） channels are membrane pro- teins that are responsible for the propagation of action potentials in mammals by mediating Na~ influx in excitable cells such as nerve and muscle. In human, Nay channels are therapeutic targets as their mutations con- tribute to many diseases. Structures of prokaryotic Nay channels, e.g., NavAb （Payandeh et al., 2011）, NavRh （Zhang et al., 2012） and NavMs （Mccusker et al., 2012）, were successively determined in the past years. Recently, the cryo-EM structures of two eukaryotic Nay channels were reported （Shen et al., 2017; Yan et al., 2017）. Nay channels contain 24 transmembrane helices.展开更多
基金We gratefully thank Dr. Huaizong Shen and Dr. Gaoxingyu Huang for their assistance in preparing the figure of the electron density map of NavPaS. This work was supported by the National Natural Science Foundation of China （Grant Nos. 31670723 and 31621092） and by the funds from the Ministry of Science and Technology of China （No. 2015CB910100） as well as the Beijing Advanced Innovation Center for Structural Biology.
文摘Dear Editor, Voltage-gated sodium （Nav） channels are membrane pro- teins that are responsible for the propagation of action potentials in mammals by mediating Na~ influx in excitable cells such as nerve and muscle. In human, Nay channels are therapeutic targets as their mutations con- tribute to many diseases. Structures of prokaryotic Nay channels, e.g., NavAb （Payandeh et al., 2011）, NavRh （Zhang et al., 2012） and NavMs （Mccusker et al., 2012）, were successively determined in the past years. Recently, the cryo-EM structures of two eukaryotic Nay channels were reported （Shen et al., 2017; Yan et al., 2017）. Nay channels contain 24 transmembrane helices.
