The maintenance of proteostasis is essential for cellular and organism healthspan.How proteostasis collapse influences reproductive span remains largely unclear.In Caenorhabditis elegans,excess accumulation of vitello...The maintenance of proteostasis is essential for cellular and organism healthspan.How proteostasis collapse influences reproductive span remains largely unclear.In Caenorhabditis elegans,excess accumulation of vitellogenins,the major components in yolk proteins,is crucial for the development of the embryo and occurs throughout the whole body during the aging process.Here,we show that vitellogenin accumulation leads to reproduction cessation.Excess vitellogenin is accumulated in the intestine and transported into the germline,impairing lysosomal activity in these tissues.The lysosomal function in the germline is required for reproductive span by maintaining oocyte quality.In contrast,autophagy and sperm depletion are not involved in vitellogenin accumulation-induced reproductive aging.Our findings provide insights into how proteome imbalance has an impact on reproductive aging and imply that improvement of lysosomal function is an effective approach for mid-life intervention for maintaining reproductive health in mammals.展开更多
基金supported by the National Natural Science Foundation of China (U1802233)the Major Science and Technology Project in Yunnan Province of China (202001BB050001)。
文摘The maintenance of proteostasis is essential for cellular and organism healthspan.How proteostasis collapse influences reproductive span remains largely unclear.In Caenorhabditis elegans,excess accumulation of vitellogenins,the major components in yolk proteins,is crucial for the development of the embryo and occurs throughout the whole body during the aging process.Here,we show that vitellogenin accumulation leads to reproduction cessation.Excess vitellogenin is accumulated in the intestine and transported into the germline,impairing lysosomal activity in these tissues.The lysosomal function in the germline is required for reproductive span by maintaining oocyte quality.In contrast,autophagy and sperm depletion are not involved in vitellogenin accumulation-induced reproductive aging.Our findings provide insights into how proteome imbalance has an impact on reproductive aging and imply that improvement of lysosomal function is an effective approach for mid-life intervention for maintaining reproductive health in mammals.
