Hepatocellular carcinoma(HCC) is the predominant subject of liver malignancies which arouse global concern. Advanced studies have found that long noncoding RNAs(lnc RNAs) are differentially expressed in HCC and implic...Hepatocellular carcinoma(HCC) is the predominant subject of liver malignancies which arouse global concern. Advanced studies have found that long noncoding RNAs(lnc RNAs) are differentially expressed in HCC and implicate they may play distinct roles in the pathogenesis and metastasis of HCC. However, the underlying mechanisms remain largely unclear. In this review, we summarized the functions and mechanisms of those known aberrantly expressed lncR NAs identified in human HCC tissues. We hope to enlighten more comprehensive researches on the detailed mechanisms of lncR NAs and their application in clinic, such as being used as diagnostic and prognostic biomarkers and the targets for potential therapy. Although studies on lncR NAs in HCC are still deficient, an improved understanding of the roles played by lncR NAs in HCC will lead to a much more effective utilization of those lnc RNAs as novel candidates in early detection, diagnosis, prevention and treatment of HCC.展开更多
Dear editor,Ovarian cancer is one of the most prevalent gynecological malignant tumors.Its five-year overall survival rate is less than 30%,mostly due to advanced metastasis and chemotherapy resistance[1].However,the ...Dear editor,Ovarian cancer is one of the most prevalent gynecological malignant tumors.Its five-year overall survival rate is less than 30%,mostly due to advanced metastasis and chemotherapy resistance[1].However,the mechanisms involved in ovarian cancer metastasis are still poorly understood.Hypoxia is a tumor microenvironment(TME)factor that facilitates tumor progression[2].Changes in TME and cross-talk signaling pathway is crucial for ovarian cancer metastasis and indicate that these tumor biological characteristics are ruled by lots of conserved mechanisms[3,4].Exosomes are crucial signalosomes between various cell types crosstalk and can carry complex mRNAs and microRNAs(miRNAs)functions between cells[5].Tumor-derived exosomes(TDEs)have been shown to not only contribute to TME remodeling but also as a contributor to premetastatic niche formation[6].There are evidence showing that cancer-secreted miRNAs may mediate cell-cell communication in many diseases,including ovarian cancer.For instance,Liu X et al.展开更多
基金Supported by Partly Fund of Guangxi Provincial Health Bureau Scientific Research Project,No.Z2014054Youth Science Foun-dation of Guangxi Medical University,No.GXMUYSF201311+4 种基金Guangxi University Science and Technology Research Projects,No.LX2014075Natural Science Foundation of GuangxiNos.2015GXNSFBA139157,2015GXNSFCA139009National Natural Science Foundation of China,Nos.NSFC81360327,NSFC81560489NSFC81560469
文摘Hepatocellular carcinoma(HCC) is the predominant subject of liver malignancies which arouse global concern. Advanced studies have found that long noncoding RNAs(lnc RNAs) are differentially expressed in HCC and implicate they may play distinct roles in the pathogenesis and metastasis of HCC. However, the underlying mechanisms remain largely unclear. In this review, we summarized the functions and mechanisms of those known aberrantly expressed lncR NAs identified in human HCC tissues. We hope to enlighten more comprehensive researches on the detailed mechanisms of lncR NAs and their application in clinic, such as being used as diagnostic and prognostic biomarkers and the targets for potential therapy. Although studies on lncR NAs in HCC are still deficient, an improved understanding of the roles played by lncR NAs in HCC will lead to a much more effective utilization of those lnc RNAs as novel candidates in early detection, diagnosis, prevention and treatment of HCC.
基金supported by the National Natural Science Foundation of China(81301789)the Shandong Province Natural Science Foundation(ZR2011HQ013)+1 种基金the Key Research and Development Projects in Shandong Province,China(2016GSF201150)the Scientific and Technological Development Projects of Shandong Province Medical and Health Science(No.2015WS0244).
文摘Dear editor,Ovarian cancer is one of the most prevalent gynecological malignant tumors.Its five-year overall survival rate is less than 30%,mostly due to advanced metastasis and chemotherapy resistance[1].However,the mechanisms involved in ovarian cancer metastasis are still poorly understood.Hypoxia is a tumor microenvironment(TME)factor that facilitates tumor progression[2].Changes in TME and cross-talk signaling pathway is crucial for ovarian cancer metastasis and indicate that these tumor biological characteristics are ruled by lots of conserved mechanisms[3,4].Exosomes are crucial signalosomes between various cell types crosstalk and can carry complex mRNAs and microRNAs(miRNAs)functions between cells[5].Tumor-derived exosomes(TDEs)have been shown to not only contribute to TME remodeling but also as a contributor to premetastatic niche formation[6].There are evidence showing that cancer-secreted miRNAs may mediate cell-cell communication in many diseases,including ovarian cancer.For instance,Liu X et al.
