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Protective Effect of Chlorogenic Acid against Carbon Tetrachloride-induced Acute Liver Damage in Rats 被引量:4
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作者 Zong-xi sun Song Liu +1 位作者 Zhi-quan Zhao rui-qiang su 《Chinese Herbal Medicines》 CAS 2014年第1期36-41,共6页
Objective To evaluate the protective effect of chlorogenic acid (CGA) on carbon tetrachloride (CCh)-induced liver injury of rats. Methods The anti-oxidative activity of CGA was investigated with several establishe... Objective To evaluate the protective effect of chlorogenic acid (CGA) on carbon tetrachloride (CCh)-induced liver injury of rats. Methods The anti-oxidative activity of CGA was investigated with several established in vitro systems. The hepatoprotective activity of CGA against CCI4-induced acute liver injury in eats was studied. The levels of alanine aminotranferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TB) were measured. The histopathological examination was carried out to supplement the biochemical results. Results CGA possessed strong anti-oxidative ability in vitro. The CCh-induced liver toxicity experiment showed that the rats pretreated with CGA (300 or 500 mg/kg) had lower levels of ALT, AST, ALP, and TB than those of the CCI4-treated group. These data were supplemented with histopathological examination of rat liver sections. CGA did not show any mortality at the dose up to 5000 mg/kg. Conclusion CGAcould protect the liver againstCCI4-induced oxidative damage in rats, and the possible mechanism of the activity may be due to its free radical-scavenging and anti-oxidative activity. 展开更多
关键词 acute liver damage ANTI-OXIDATION carbon tetrachloride chlorogenic acid HEPATOPROTECTION
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