Antipsychotics such as phenothiazines,pimozide,flupentixol and brexpiprazole have been shown to have good antitumor effects.Brexpiprazole,the successor to aripiprazole,has a better safety profile.Brexpiprazole promote...Antipsychotics such as phenothiazines,pimozide,flupentixol and brexpiprazole have been shown to have good antitumor effects.Brexpiprazole,the successor to aripiprazole,has a better safety profile.Brexpiprazole promotes the death of tumor cells by inhibiting the prolif-eration of tumor stem cells,resolving the resistance of tumor cells to EGFR-TKIs,and promoting the sensitivity of tumor cells to chemothera-peutic agents,thus inhibiting the development of colorectal,lung,glioblastoma,pancreatic,and gastric cancers.This review focuses on the antitumor effects of antipsychotic drugs,especially the inhibitory effect of brexpiprazole on tumor cells,aiming to provide a theoretical basis for antipsychotic drugs in antitumor field.展开更多
文摘Antipsychotics such as phenothiazines,pimozide,flupentixol and brexpiprazole have been shown to have good antitumor effects.Brexpiprazole,the successor to aripiprazole,has a better safety profile.Brexpiprazole promotes the death of tumor cells by inhibiting the prolif-eration of tumor stem cells,resolving the resistance of tumor cells to EGFR-TKIs,and promoting the sensitivity of tumor cells to chemothera-peutic agents,thus inhibiting the development of colorectal,lung,glioblastoma,pancreatic,and gastric cancers.This review focuses on the antitumor effects of antipsychotic drugs,especially the inhibitory effect of brexpiprazole on tumor cells,aiming to provide a theoretical basis for antipsychotic drugs in antitumor field.
