Neuroinflammation is an important pathological feature and an early event in the pathogenesis of Alzheimer's disease(AD),which is characterized by activation of microglia and astrocytes.Low-density lipoprotein rec...Neuroinflammation is an important pathological feature and an early event in the pathogenesis of Alzheimer's disease(AD),which is characterized by activation of microglia and astrocytes.Low-density lipoprotein receptor related protein 1(LRP1)is an endocytic receptor that is abundantly expressed in neurons,microglia,and astrocytes,and plays a critical role in AD pathogenesis.There is increasing evidence to show that LRP1 regulates inflammatory responses by modulating the release of pro-inflammatory cytokines and phagocytosis.展开更多
Alkenes are ubiquitous,and the difunctionalization of alkenes represents one of the most practical approaches for the construction of value-added compounds.Dicarbonylation of alkenes provides direct access to value-ad...Alkenes are ubiquitous,and the difunctionalization of alkenes represents one of the most practical approaches for the construction of value-added compounds.Dicarbonylation of alkenes provides direct access to value-added 1,4-dicarbonyl compounds.However,selectivity control for unsymmetric 1,2-dicarbonylation is of great challenge.We herein describe NHCs and photocatalysis co-catalyzed three-component radical 1,2-dicarbonylation of alkenes by distinguishing two carbonyl groups,providing structurally diversified 1,4-diketones.Distinct properties of acyl radical and NHCs-stabilized ketyl radical contributed to selectivity control.Acyl radicals are rapidly added to alkenes delivering alkyl radicals,which undergo subsequent radicalradical cross-coupling with NHCs-stabilized ketyl-type radicals,affording 1,2-dicarbonylation products.This transformation features mild reaction conditions,broad substrate scope,and excellent selectivity,providing a general and practical approach for the dicarbonylation of olefins.展开更多
文摘Neuroinflammation is an important pathological feature and an early event in the pathogenesis of Alzheimer's disease(AD),which is characterized by activation of microglia and astrocytes.Low-density lipoprotein receptor related protein 1(LRP1)is an endocytic receptor that is abundantly expressed in neurons,microglia,and astrocytes,and plays a critical role in AD pathogenesis.There is increasing evidence to show that LRP1 regulates inflammatory responses by modulating the release of pro-inflammatory cytokines and phagocytosis.
基金supported by the National Natural Science Foundation of China (22001157,21831002,22193012)the Ten Thousand Talents Program+2 种基金the Fundamental Research Funds for the Central Universities (2412022QD016,2412021QD007)the Natural Science Foundation of Jilin Province (YDZJ202201ZYTS338)the Natural Science Foundation of Shaanxi Province (2020JQ-404)
文摘Alkenes are ubiquitous,and the difunctionalization of alkenes represents one of the most practical approaches for the construction of value-added compounds.Dicarbonylation of alkenes provides direct access to value-added 1,4-dicarbonyl compounds.However,selectivity control for unsymmetric 1,2-dicarbonylation is of great challenge.We herein describe NHCs and photocatalysis co-catalyzed three-component radical 1,2-dicarbonylation of alkenes by distinguishing two carbonyl groups,providing structurally diversified 1,4-diketones.Distinct properties of acyl radical and NHCs-stabilized ketyl radical contributed to selectivity control.Acyl radicals are rapidly added to alkenes delivering alkyl radicals,which undergo subsequent radicalradical cross-coupling with NHCs-stabilized ketyl-type radicals,affording 1,2-dicarbonylation products.This transformation features mild reaction conditions,broad substrate scope,and excellent selectivity,providing a general and practical approach for the dicarbonylation of olefins.
