Case Study on AI Robotics in Senior Living in China

Currently,in China,as the elderly population rapidly increases due to the increase in aging,the importance of the elderly’s living environment and quality of life is increasing.Accordingly,the development of technology presents the possibility of providing a better life to the elderly.This study is conducted to investigate and analyze the current status and performance of artificial intelligence robot technology introduced in the elderly residential space in China,and contribute to the improvement of the living and convenience of the elderly.First,we investigate the cases of various types of artificial intelligence robots currently being used in the residential environment for the elderly in China.Second,by evaluating the technical performance and function of each artificial intelligence robot,we will look at how it meets the needs of the elderly’s special bedfall,health care,and social interaction.Third,we analyze the impact of artificial intelligence robots on the daily life of the elderly and investigate users’experiences and effects to understand social effects.Fourth,based on the obtained results,suggestions and future prospects for effectively introducing artificial intelligence robots into the residential environment for the elderly in China are presented.Through this,it is expected to contribute to understanding how artificial intelligence robot technology is being applied in the residential environment of the elderly in China,and to find ways to improve the convenience and quality of life of the elderly.

Comparative analysis on gas–solid drag models in MFIX-DEM simulations of bubbling fluidized bed

In this study,the open-source software MFIX-DEM simulations of a bubbling fluidized bed(BFB)are applied to assess nine drag models according to experimental and direct numerical simulation(DNS)results.The influence of superficial gas velocity on gas–solid flow is also examined.The results show that according to the distribution of time-averaged particle axial velocity in y direction,except for Wen–Yu and Tenneti–Garg–Subramaniam(TGS),other drag models are consistent with the experimental and DNS results.For the TGS drag model,the layer-by-layer movement of particles is observed,which indicates the particle velocity is not correctly predicted.The time domain and frequency domain analysis results of pressure drop of each drag model are similar.It is recommended to use the drag model derived from DNS or fine grid computational fluid dynamics–discrete element method(CFD-DEM)data first for CFD-DEM simulations.For the investigated BFB,the superficial gas velocity less than 0.9 m·s^(-1) should be adopted to obtain normal hydrodynamics.

Application of shear-sensitive liquid crystal coating to visualization of transition and reattachment in compressor cascade

The present paper aims at introducing Shear-Sensitive Liquid Crystal Coating(SSLCC)technology into compressor cascade measurement for the first time and serves as a basis for better understanding of the influence from the boundary layers. Optical path layout, which is the most significant difficulty in internal flow field measurement, will be solved in this paper by selfdesigned image acquisition device. Massive experiments with different Mach number and incidence are conducted at a continuous subsonic cascade wind tunnel to capture the boundary layer phenomenon. Image processing methods, such as Three-Dimensional(3-D) reconstruction and Hue conversion, are used to improve the accuracy for transition position detection. The analysis of the color-images indicates that complex flow phenomena including transition, flow separation,and reattachment are captured successfully, and the effect of Mach number and incidence on the boundary layer flow is also discussed. The results show that: the Mach number has a significant effect on transition position; the incidence has little effect on transition position, but it has a great impact on the transition distance and leading-edge separation; influenced by the end-walls, the reattachment occurs in advance under positive angle of attack conditions.

Genomic characterization reveals distinctmutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract

Background:Neuroendocrine carcinomas of the gastrointestinal tract(GINECs)remain a disease of grim prognosis with limited therapeutic options.Their molecular characteristics are still undefined.This study aimed to explore the underlying genetic basis and heterogeneity of GI-NECs.Methods:Comprehensive genomic analysis using whole-exome sequencing was performed on 143 formalin-fixed,paraffin-embedded samples of surgically resected GI-NEC with a thorough histological evaluation.Mutational signatures,somatic mutations,and copy number aberrations were analyzed and compared across anatomic locations and histological subtypes.Survival analysis was conducted to identify the independent factors.Results:In total,143GI-NECswere examined:the stomach,87 cases(60.8%);the esophagus,29 cases(20.3%);the colorectum,20 cases(14.0%);and the small intestine,7 cases(4.9%).Eighty-three(58.0%)and 60(42.0%)cases were subclassified into small cell and large cell subtypes,respectively.GI-NECs showed distinct genetic alterations from their lung counterparts and non-neuroendocrine carcinomas in the same locations.Obvious heterogeneity of mutational signatures,somatic mutations,and copy number variations was revealed across anatomic locations rather than histological subtypes.Except for tumor protein p53(TP53)and retinoblastoma 1(RB1),the most frequently mutated genes in the stomach,esophagus,colorectum,and small intestine were low-density lipoprotein receptor-related protein 1B(LRP1B),notch receptor 1(NOTCH1),adenomatosis polyposis coli(APC),catenin beta 1(CTNNB1),respectively.Mutations in the WNT-β-catenin,NOTCH and erythroblastic leukemia viral oncogene B(ERBB)pathwayswere prevalently identified in gastric,esophageal,and colorectalNECs,respectively.Importantly,104(72.7%)GI-NECs harbored putative clinically relevant alterations,and non-gastric location and RB1 bi-allelic inactivation with copy number alterations were identified as two independent poor prognostic factors.Furthermore,we found that tumor cells in GI-NECs first gain clonal mutations in TP53,RB1,NOTCH1 and APC,followed by subsequent wholegenome doubling(WGD)and post-WGD clonal mutations in LRP1B,CUB and Sushi multiple domains 3(CSMD3),FAT tumor suppressor homolog 4(FAT4)and erb-b2 receptor tyrosine kinase 4(ERBB4),and finally develop subclonal mutations.Conclusions:GI-NECs harbor distinct genomic landscapes and demonstrate significant genetic heterogeneity across different anatomic locations.Moreover,potentially actionable alterations and prognostic factors were revealed for GI-NECs.

浅析醒脑开窍针刺法治疗缺血性脑卒中肢体功能障碍针刺时机研究的思路构建与方案设计

针刺时机研究不仅可以协助找寻疾病的最佳针刺治疗时机,同时可以最大化针刺的治疗效果,提高患者的康复几率。时机研究中混杂因素众多,而针刺作为一种复杂的个体化干预措施,进一步加大了研究的难度。该文通过分析总结"醒脑开窍针刺法治疗缺血性脑卒中肢体功能障碍针刺时机研究"的方案设计要点,从暴露分组、研究人群、纳排标准、结局指标、Logistic多因素回归分析、配对设计、偏倚控制等方面对针刺时机研究方案的设计和实施进行论述,以期为后续此类研究提供更加新颖开阔的研究思路。

Experimental investigation on static/dynamic characteristics of a fast-response pressure sensitive paint

An optical-based technique using Pressure-Sensitive Paint(PSP) is a promising method to measure the distribution of surface pressure on an aerodynamic model. The static and dynamic characteristics of a fast-response PSP that is developed in the Chinese Academy of Sciences(CAS)are analyzed and tested to serve as the basis for experiments on unsteady surface measurement using a fast-response PSP. Two calibration systems used for this study are set up to investigate the temperature dependency, response time, and resolution. A data processing method, used for dynamic data, is analyzed and selected carefully to determine the optimum signal. Results show that the fastresponse PSP can be used normally at temperatures from 25 ℃ to 80 ℃. The effect of temperature on the accuracy of the measurement must be considered when temperatures are beyond the temperature range of 30–40 ℃. The dynamic calibration device with a solenoid valve can achieve a pressure jump within a millisecond order. The resolution is determined by the signal-to-noise ratio of the photo-multiplier tube. Results of the measurement show that the response time of the PSP decreases with a large pressure variation, and the response time is below 0.016 s when the pressure variation is under 40 kPa.

Influence of leading edge with real manufacturing error on aerodynamic performance of high subsonic compressor cascades

To investigate the influence of real leading-edge manufacturing error on aerodynamic performance of high subsonic compressor blades,a family of leading-edge manufacturing error data were obtained from measured compressor cascades.Considering the limited samples,the leadingedge angle and leading-edge radius distribution forms were evaluated by Shapiro-Wilk test and quantile–quantile plot.Their statistical characteristics provided can be introduced to later related researches.The parameterization design method B-spline and Bezier are adopted to create geometry models with manufacturing error based on leading-edge angle and leading-edge radius.The influence of real manufacturing error is quantified and analyzed by self-developed non-intrusive polynomial chaos and Sobol’indices.The mechanism of leading-edge manufacturing error on aerodynamic performance is discussed.The results show that the total pressure loss coefficient is sensitive to the leading-edge manufacturing error compared with the static pressure ratio,especially at high incidence.Specifically,manufacturing error of the leading edge will influence the local flow acceleration and subsequently cause fluctuation of the downstream flow.The aerodynamic performance is sensitive to the manufacturing error of leading-edge radius at the design and negative incidences,while it is sensitive to the manufacturing error of leading-edge angle under the operation conditions with high incidences.

Effect of H_2 Reduction Temperature on the Properties of Reduced Graphene Oxide and Copper Matrix Composites

Reduced graphene oxide(RGO) and copper composites(RGO/Cu) were successfully fabricated based on a molecular-level mixing method(MLM). The composite powders were reduced in H2 at 350, 450, and 550 °C and then consolidated by spark plasma sintering(SPS) in order to evaluate the effect of H2 reduction temperature on the properties of the composites. The results indicate that the strengths of the composite decrease with the increase of H2 reduction temperature, while the electrical conductivity reaches its maximum at 450 °C and minimum at 550 °C. Hot rolling could benefit the electrical conductivity. The yield strength of the RGO/Cu composite reduced to 337 MPa at 350 °C. The electrical conductivity of the RGO/Cu composite reduced at 450 °C after hot rolling reaches 60.26% IACS. The properties of the RGO/Cu composites can be designed by adjusting the reduction degree of RGO and by hot rolling.

Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum

典型药用的植物的主要成分，蓼 multiflorum (用汉语的 Heshouwu ) ，那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害，而独唱治疗不能导致看得见的损害。在现在的工作，用成分大美人和敲门在里面策略，我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase， aspartate aminotransferase，和肝 histologic 的重要举起变化，而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且，孤立的 cis- ，并且不它的 trans 异构体，显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外，血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停，我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。

Effect of hypoglycemic anti-deafness capsules in diabetic patients with deafness and toxicological assessment in rats

OBJECTIVE:Through experiment on animals and clinical trials to explore the safety and efficacy of hypoglycemic anti-deafness capsules on diabetic patients with deafness.METHODS:Total 296 patients with non-insulin dependent diabetes mellitus(NIDDM)were randomly divided into two groups.A treatment group of 164patients(208 ears)was treated with hypoglycemic anti-deafness capsules based onTCM syndrome differentiation.A control group of 132 patients(184ears)was treated with glibenclamide and conventional drug treatment for deafness.The following were observed:hearing,fasting plasma glucose(FPG),2 h postprandial plasma glucose(2hPG),24 h urine glucose(24hUG),improvement of main symptoms,platelet function,and changes in superoxidedismutase(SOD)and lipid peroxide(LPO)levels.In animal studies,Kunming mice,weighing 18-22 g were used.Half of the mice were males and half were females.Wistar rats,weighing 80-120 g were used.Half of the rats were males and half were females.Male Wistar rats,weighing 200-220 g,were also used.Their acute and chronic toxicity was studied.RESULTS:The hearing improvement was 56.7%in the treatment group and 26.6%in the control group.FPG,2hPG,and 24hUG were improved significantly(P<0.05,P<0.01,P<0.01,respectively)in the treatment group and 2hPG and 24hUG improved significantly in the control group(P<0.05,P<0.05).The improvement in 2hPG and 24hUG in the treatment group was significantly greater than that in the control group P<0.01).There was no significant difference in FPG between the two groups(P<0.05).Main symptoms in the treatment group were significantly more improved than those in the control group(P<0.05,P<0.01).In the treatment group,platelet adhesion and aggregation,SOD,and LPO were all significantly improved from before treatment(P<0.05,P<0.01).However,in the control group,except LOP(P<0.05),there were no significant differences from before treatment to after(P<0.05).In animal studies,no obvious acute or long-term toxicity was observed from capsule administration.CONCLUSION:Through experiment on animals and clinical trials,we can found that hypoglycemic anti-deafness capsules could decrease blood glucose and serum triglycerides of alloxan-induced diabetic rats.This herbal capsule is effective for safely treating diabetic patients with deafness.

Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb,Polygonum multiflorum

Erratum to Frontiers of Medicine 201711(2):253–265 https://doi.org/10.1007/s11684-017-0508-9 The original version of this article unfortunately contained some mistakes.The panel of“LPS–/drug–”in Fig.3B(Page 259),the panels of“LPS–/EtoAc+”and“LPS–/Residue+”in Supplementary Fig.3(Page 7 in the online supplementary materials)should be corrected.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.