自供电电刺激辅助皮肤伤口治疗

Skin wounds are one of the most common and major global public health problems.As the human body’s largest organ,the skin is extremely vulnerable to invasion and damage by various physical,chemical,or biological factors[1].Disruption of skin integrity means loss of its barrier function,which may lead to damage to the deeper tissues or disturbance of the internal microenvironment.It is estimated that 1%–2%of the world’s population will experience chronic trauma during their lifetime,especially in recent years,the rising incidence has led to increased socioeconomic burden,making skin trauma an increasingly important clinical problem[2].

Rapidly separable bubble microneedle patch for effective local anesthesia

In cutaneous cosmetology surgery,local injection or coated anesthetics are generally used to provide analgesia at the treatment site to achieve painless operation.Due to the barrier of corneum,topical cream may cause uncertain dosage and delayed analgesia.Local injection has problems such as pain,infection,and misoperation.Therefore,it is necessary to develop a painless and rapid administration method for local anesthesia.Here,a lidocaine/hyaluronic acid bubble microneedle patch(Lido/HA bMNP)was prepared for rapid drug delivery and efficient analgesia.The bubble structure between microneedles(MNs)and the backing layer allowed the MNs to efficiently penetrate into the skin and remove from the backing layer under shear force to rapidly complete the administration.Drugs were quickly released with the dissolution of HA within 15 s,which immediately played an analgesic effect and lasted for 1 h.Lido/HA bMNP could deliver precise doses to the skin in an extremely short time,which had the advantages of convenient operation,high biosafety,rapid onset of analgesia,and reasonable pain relief time.This patch provided an alternative way for local anesthesia and it was a promising transdermal drug delivery method for the realization of high quality and efficiency“painless medical beauty”.

Localized Myocardial Anti-Inflammatory Effects of Temperature-Sensitive Budesonide Nanoparticles during Radiofrequency Catheter Ablation

Radiofrequency(RF)catheter ablation has emerged as an effective alternative for the treatment of atrial fibrillation(AF),but ablation lesions will result in swelling and hematoma of local surrounding tissue,triggering inflammatory cell infiltration and increased release of inflammatory cytokines.Some studies have shown that the inflammatory response may be related to the early occurrence of AF.The most direct way to inhibit perioperative inflammation is to use anti-inflammatory drugs such as glucocorticoids.Here,we prepared polylactic-co-glycolic acid(PLGA)nanoparticles loaded with budesonide(BUD)and delivered them through irrigation of saline during the onset of ablation.Local high temperature promoted local rupture of PLGA nanoparticles,releasing BUD,and produced a timely and effective local myocardial anti-inflammatory effect,resulting in the reduction of acute hematoma and inflammatory cell infiltration and the enhancement of ablation effect.Nanoparticles would also infiltrate into the local myocardium and gradually release BUD ingredients to produce a continuous antiinflammatory effect in the next few days.This resulted in a decrease in the level of inflammatory cytokine IL-6 and an increase of anti-inflammatory cytokine IL-10.This study explored an extraordinary drug delivery strategy to reduce ablation-related inflammation,which may prevent early recurrence of AF.