Preventing local tumor recurrence while promoting bone tissue regeneration is an urgent need for osteosarcoma treatment.However,the therapeutic efficacy of traditional photosensitizers is limited,and they lack the abi...Preventing local tumor recurrence while promoting bone tissue regeneration is an urgent need for osteosarcoma treatment.However,the therapeutic efficacy of traditional photosensitizers is limited,and they lack the ability to regenerate bone.Here,a piezo-photo nanoheterostructure is developed based on ultrasmall bismuth/strontium titanate nanocubes(denoted as Bi/SrTiO_(3)),which achieve piezoelectric field-driven fast charge separation coupling with surface plasmon resonance to efficiently generate reactive oxygen species.These hybrid nanotherapeutics are integrated into injectable biopolymer hydrogels,which exhibit outstanding anticancer effects under the combined irradiation of NIR and ultrasound.In vivo studies using patient-derived xenograft models and tibial osteosarcoma models demonstrate that the hydrogels achieve tumor suppression with efficacy rates of 98.6%and 67.6%in the respective models.Furthermore,the hydrogel had good filling and retention capabilities in the bone defect region,which exerted bone repair therapeutic efficacy by polarizing and conveying electrical stimuli to the cells under mild ultrasound radiation.This study provides a comprehensive and clinically feasible strategy for the overall treatment and tissue regeneration of osteosarcoma.展开更多
基金supported by the National Key R&D Program of China(Nos.2021YFC2400402 and 2021YFC2400405)the National Natural Science Foundation of China(Nos.52072127,52173275,52201297,51932002)+3 种基金Beijing Municipal Health Commission(BJRITO-RDP-2023,PXM 2020_026275_000002 and BMHC-2021-6)the Natural Science Foundation of Guangdong Province(2021A0505030083 and 202201010228)the Guangdong Basic and Applied Basic Research Foundation(2023A1515010784)the China Postdoctoral Science Foundation(No.2023M743979).
文摘Preventing local tumor recurrence while promoting bone tissue regeneration is an urgent need for osteosarcoma treatment.However,the therapeutic efficacy of traditional photosensitizers is limited,and they lack the ability to regenerate bone.Here,a piezo-photo nanoheterostructure is developed based on ultrasmall bismuth/strontium titanate nanocubes(denoted as Bi/SrTiO_(3)),which achieve piezoelectric field-driven fast charge separation coupling with surface plasmon resonance to efficiently generate reactive oxygen species.These hybrid nanotherapeutics are integrated into injectable biopolymer hydrogels,which exhibit outstanding anticancer effects under the combined irradiation of NIR and ultrasound.In vivo studies using patient-derived xenograft models and tibial osteosarcoma models demonstrate that the hydrogels achieve tumor suppression with efficacy rates of 98.6%and 67.6%in the respective models.Furthermore,the hydrogel had good filling and retention capabilities in the bone defect region,which exerted bone repair therapeutic efficacy by polarizing and conveying electrical stimuli to the cells under mild ultrasound radiation.This study provides a comprehensive and clinically feasible strategy for the overall treatment and tissue regeneration of osteosarcoma.
