MOF-Like 3D Graphene-Based Catalytic Membrane Fabricated by One-Step Laser Scribing for Robust Water Purification and Green Energy Production

Increasing both clean water and green energy demands for survival and development are the grand challenges of our age.Here,we successfully fabricate a novel multifunctional 3D graphene-based catalytic membrane(3D-GCM)with active metal nanoparticles(AMNs)loading for simultaneously obtaining the water purification and clean energy generation,via a“green”one-step laser scribing technology.The as-prepared 3D-GCM shows high porosity and uniform distribution with AMNs,which exhibits high permeated fluxes(over 100 L m^(−2) h^(−1))and versatile super-adsorption capacities for the removal of tricky organic pollutants from wastewater under ultra-low pressure-driving(0.1 bar).After adsorption saturating,the AMNs in 3D-GCM actuates the advanced oxidization process to self-clean the fouled membrane via the catalysis,and restores the adsorption capacity well for the next time membrane separation.Most importantly,the 3D-GCM with the welding of laser scribing overcomes the lateral shear force damaging during the long-term separation.Moreover,the 3D-GCM could emit plentiful of hot electrons from AMNs under light irradiation,realizing the membrane catalytic hydrolysis reactions for hydrogen energy generation.This“green”precision manufacturing with laser scribing technology provides a feasible technology to fabricate high-efficient and robust 3D-GCM microreactor in the tricky wastewater purification and sustainable clean energy production as well.

基于二维异质结的空穴主导福勒-诺德海姆隧穿器件应用于红外成像

基于多种二维材料的异质结结构能够有效调控并提高器件性能,在光电探测领域拥有巨大的潜力.然而,大多数已报道的基于一类和二类能带结构的异质结器件存在热载流子浓度高的问题,因此光电流和暗电流比值低、并且受到温度的较大影响,导致光电探测器性能受限.本文报道了二碲化钼/六方氮化硼/二碲化钼/六方氮化硼异质结结构中,在无光照及有光照条件下空穴主导的福勒-诺德海姆量子隧穿输运.该器件在室温环境和低于0.3 nWμm^(-2)激光功率密度的条件下,实现了高于10^(8)的探测率.该器件较快的开关比和高灵敏的探测性能成功地验证了成像功能.将隧穿机制与二维材料多种独特的性质相结合对于新型光电探测器的研究具有重要意义.

Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis

Currently, there is still no effective curative treatment for the development of late-stage liver fibrosis. Here, we have illustrated that TB001, a dual glucagon-like peptide-1 receptor/glucagon receptor(GLP-1 R/GCGR) agonist with higher affinity towards GCGR, could retard the progression of liver fibrosis in various rodent models, with remarkable potency, selectivity, extended half-life and low toxicity. Four types of liver fibrosis animal models which were induced by CCl_(4), a-naphthyl-isothiocyanate(ANIT), bile duct ligation(BDL) and Schistosoma japonicum were used in our study. We found that TB001 treatment dose-dependently significantly attenuated liver injury and collagen accumulation in these animal models. In addition to decreased levels of extracellular matrix(ECM) accumulation during hepatic injury, activation of hepatic stellate cells was also inhibited via suppression of TGF-β expression as well as downstream Smad signaling pathways particularly in CCl_(4)-and S. japonicum-induced liver fibrosis. Moreover, TB001 attenuated liver fibrosis through blocking downstream activation of proinflammatory nuclear factor kappa B/NF-kappa-B inhibitor alpha(NFκB/IKBa) pathways as well as cJun N-terminal kinase(JNK)-dependent induction of hepatocyte apoptosis. Furthermore, GLP-1 R and/or GCGR knock-down results represented GCGR played an important role in ameliorating CCl_(4)-induced hepatic fibrosis. Therefore, TB001 can be used as a promising therapeutic candidate for the treatment of multiple causes of hepatic fibrosis demonstrated by our extensive pre-clinical evaluation of TB001.

Interfacial Assembly Directed Unique Mesoporous Architectures:From Symmetric to Asymmetric

CONSPECTUS:Functional mesoporous materials have experienced flourishing developments over the past 30 years,and they are now a big family including large variety of compositions and architectures.Due to large surface area,high pore volume,tunable pore size,and unique mesostructures,mesoporous nanomaterials have been widely used in catalysis,energy conversion and storage,drug delivery,etc.Out of the various methods of architecting mesoporous materials,the soft-templating method that allows regulating the architecture by tuning the assembly process,is used mostly for fabricating mesoporous materials.In soft templating methods,amphiphilic surfactants and precursors assemble into“soft”micelles,and micelles further assemble into mesoporous materials.Usually,micelles homogeneously nucleate and assemble into mesoporous nanomaterials.Such a homogeneous assembly process naturally leads to“routine”structures such as nanospheres or other symmetric architectures.Introduction of nanoparticles during the micelle assembly process results in conventional core@shell structures,which though combining the mesoporous shell and functional core,is still simple.Nowadays,growing demands in diverse applications urgently require mesoporous nanomaterials with novelty in mesostructures,compositions,surface properties,morphologies,functionalities,etc.Therefore,researchers have been seeking to gain better control of the micelles’assembly process,pursuing the synthesis of mesoporous nanomaterials with unique architectures,especially morphology,mesostructure,surface chemistry,etc.Recently,the effect of“interface”during micelles’assembly process has aroused great attention.The introduction of an interface into the reaction system turns the micelles’homogeneous assembly into a heterogeneous one,altering their assembly behavior and thus leading to mesoporous nanomaterials with unique architectures.By manipulation of the interfacial-assembly behavior of micelles,a series of mesoporous nanomaterials with unique architectures have been developed,with structures ranging from symmetric to asymmetric.In this Account,the recent progresses in interfacial-assembly-directed mesoporous nanomaterials with unique architectures,both the fabrication and applications are systematic reviewed.The architectures of the obtained mesoporous nanomaterials are categorized into symmetric and asymmetric,including virus-like,bouquet-like,multishell hollow structures,and also Janus,multipods,hemisphere structures,etc.We introduced how interfaces such as nanoparticle−surface,water−oil interface,macropore scaffold interfaces,etc.are utilized to direct the assembly of micelles.The methods of controlling micelles’interfacial-assembly behavior,such as biphasic assembly method,interfacial-energy method,interface tension method,and so on are highlighted.The applications of these unique mesoporous nanomaterials in fields of catalysis,energy conversion,and biomedicine are surveyed.At the end of the review,a brief summary of the field,as well as shortcomings,challenges,and perspectives of the field are also included.