Precise control of circulating lipid levels is vital in both health and disease.We recently uncovered that bulk lipids,transported by lipoproteins,enter the circulation initially via the coat protein complex II(COPII)...Precise control of circulating lipid levels is vital in both health and disease.We recently uncovered that bulk lipids,transported by lipoproteins,enter the circulation initially via the coat protein complex II(COPII)in a condensation-dependent manner.Divalent manganese,acting as a signaling messenger,selectively controls COPII condensation to regulate lipid homeostasis in vivo.Here,we present evidence for a manganese-based therapy in murine models of hypolipidemia and hyperlipidemia.展开更多
基金The work is supported by the National Natural Science Foundation of China(NSFC:32125021,92254308,91957119,91954001,31571213 to X.W.C,32100947 to X.W.,and 62027901 to J.T.)the National Key R&D Program(2021YFA0804802).
文摘Precise control of circulating lipid levels is vital in both health and disease.We recently uncovered that bulk lipids,transported by lipoproteins,enter the circulation initially via the coat protein complex II(COPII)in a condensation-dependent manner.Divalent manganese,acting as a signaling messenger,selectively controls COPII condensation to regulate lipid homeostasis in vivo.Here,we present evidence for a manganese-based therapy in murine models of hypolipidemia and hyperlipidemia.
