Faithful DNA duplication is the fundamental event for all life forms.How to replicate the whole genome quickly and efficiently is a challenge that must be faced within every S phase of the cell cycle[1].Considering th...Faithful DNA duplication is the fundamental event for all life forms.How to replicate the whole genome quickly and efficiently is a challenge that must be faced within every S phase of the cell cycle[1].Considering the increased size and complexity of mammalian genomes,it is plausible that the regulation of DNA replication is more intricate in mammals.Tens of thousands of replication origins have been identified throughout mammalian genomes[2].Whether replication forks originated from different origins cooperate during replication is a long-term concern in the field.展开更多
The development of thermodynamically controllable synthetic strategy to manipulate the morphology of ZIF-8 without capping agent is essential to help understanding their facet effect and the structure-activity relatio...The development of thermodynamically controllable synthetic strategy to manipulate the morphology of ZIF-8 without capping agent is essential to help understanding their facet effect and the structure-activity relationship of single atom catalysts derived from ZIF-8.Here,we prepared ZIF-8 with different morphologies(cube,truncated rhombododecahedral and rhombododecahedral)and thus area ratio of exposed{100},{110}facets by a thermodynamically controllable synthetic strategy.When the reaction proceeds under room temperature(30℃),the assembling of ZIF-8 followed an area-reducing layered growth mode,while switched to an integral layered growth mode at lower temperature-40℃.Moreover,this strategy also works to obtain ZIF-8 encapsulated with metal precursors(Fe(acac)_(3),Cu(acac)_(2)and Co(acac)_(2)).Single Fe atom anchored on nitrogen doped carbon catalysts(SA-Fe/CN)derived from Fe-ZIF-8 retain their original morphologies and the unsaturated surface-active sites on{100}facet,which further displays different catalytic performance towards oxygen reduction reaction(ORR).This work not only reveals the different growth pattern of ZIF-8,but also points out a new direction for designing and synthesizing MOFs with different morphology rationally.展开更多
文摘Faithful DNA duplication is the fundamental event for all life forms.How to replicate the whole genome quickly and efficiently is a challenge that must be faced within every S phase of the cell cycle[1].Considering the increased size and complexity of mammalian genomes,it is plausible that the regulation of DNA replication is more intricate in mammals.Tens of thousands of replication origins have been identified throughout mammalian genomes[2].Whether replication forks originated from different origins cooperate during replication is a long-term concern in the field.
基金This work was supported by the National Natural Science Foundation of China(No.22102218)the Natural Science Foundation of Hunan Province(No.2020JJ4684)+1 种基金the science and technology innovation Program of Hunan Province(No.2022RC1110)the Open Sharing Fund for the Large-scale Instruments and Equipments of Central South University(No.CSUZC202221).
文摘The development of thermodynamically controllable synthetic strategy to manipulate the morphology of ZIF-8 without capping agent is essential to help understanding their facet effect and the structure-activity relationship of single atom catalysts derived from ZIF-8.Here,we prepared ZIF-8 with different morphologies(cube,truncated rhombododecahedral and rhombododecahedral)and thus area ratio of exposed{100},{110}facets by a thermodynamically controllable synthetic strategy.When the reaction proceeds under room temperature(30℃),the assembling of ZIF-8 followed an area-reducing layered growth mode,while switched to an integral layered growth mode at lower temperature-40℃.Moreover,this strategy also works to obtain ZIF-8 encapsulated with metal precursors(Fe(acac)_(3),Cu(acac)_(2)and Co(acac)_(2)).Single Fe atom anchored on nitrogen doped carbon catalysts(SA-Fe/CN)derived from Fe-ZIF-8 retain their original morphologies and the unsaturated surface-active sites on{100}facet,which further displays different catalytic performance towards oxygen reduction reaction(ORR).This work not only reveals the different growth pattern of ZIF-8,but also points out a new direction for designing and synthesizing MOFs with different morphology rationally.
