Hepatocellular carcinoma(HCC)is a highly aggressive cancer that ranks the second leading cause of cancer related death.Hepatitis B virus(HBV)infection is the most prevalent etiological factor,especially in eastern wor...Hepatocellular carcinoma(HCC)is a highly aggressive cancer that ranks the second leading cause of cancer related death.Hepatitis B virus(HBV)infection is the most prevalent etiological factor,especially in eastern world.However,the underlying mechanism of HBV infection-initialed carcinogenic progression remains largely unknown,making it difficult to improve therapeutic strategies for HBV-associated HCC(HBV+HCC).The virus drives multi-omics changes in human liver cells,leading to genomic in stability,epigenomic modifications,and proteomic a lterations.HBV infection also orchestrates the immunosuppressive microenv ironment in HBV+HCC.This review summarized recent research progress with the multimodal methods covering genome,transcriptome,epigenome,and proteome introduced in the mechanistic studies for HBV+HCC.展开更多
文摘Hepatocellular carcinoma(HCC)is a highly aggressive cancer that ranks the second leading cause of cancer related death.Hepatitis B virus(HBV)infection is the most prevalent etiological factor,especially in eastern world.However,the underlying mechanism of HBV infection-initialed carcinogenic progression remains largely unknown,making it difficult to improve therapeutic strategies for HBV-associated HCC(HBV+HCC).The virus drives multi-omics changes in human liver cells,leading to genomic in stability,epigenomic modifications,and proteomic a lterations.HBV infection also orchestrates the immunosuppressive microenv ironment in HBV+HCC.This review summarized recent research progress with the multimodal methods covering genome,transcriptome,epigenome,and proteome introduced in the mechanistic studies for HBV+HCC.
