Protein tyrosine phosphatases(PTPs)remove phosphate groups from protein tyrosine residues to regulate various cell signaling processes,subsequently affecting the growth,metabolism,differentiation,immune response,and o...Protein tyrosine phosphatases(PTPs)remove phosphate groups from protein tyrosine residues to regulate various cell signaling processes,subsequently affecting the growth,metabolism,differentiation,immune response,and other cellular processes.Several studies have investigated the functions of PTPs in tumor and organism immunity.However,only a few studies have focused on their roles in reproductive disorders.Therefore,in this review,we summarize the roles and underlying molecular mechanisms of PTPs in infertility,spontaneous abortion,pregnancy-induced hypertension,gestational diabetes mellitus,early embryonic developmental abnormalities,and preterm birth.This review can contribute to future research on PTPs and their potential applications as targets in the treatment of reproductive diseases.展开更多
基金the National Natural Science Foundation of China(82371699 and 82120108011)National Key Research and Development Project(2022YFC2704602 and 2022YFC2704502)+1 种基金Major Project of Shanghai Municipal Education Commission’s Scientific Research and Innovation Plan(2021-01-07-00-07-E00144)Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine(FIRMA200502)。
文摘Protein tyrosine phosphatases(PTPs)remove phosphate groups from protein tyrosine residues to regulate various cell signaling processes,subsequently affecting the growth,metabolism,differentiation,immune response,and other cellular processes.Several studies have investigated the functions of PTPs in tumor and organism immunity.However,only a few studies have focused on their roles in reproductive disorders.Therefore,in this review,we summarize the roles and underlying molecular mechanisms of PTPs in infertility,spontaneous abortion,pregnancy-induced hypertension,gestational diabetes mellitus,early embryonic developmental abnormalities,and preterm birth.This review can contribute to future research on PTPs and their potential applications as targets in the treatment of reproductive diseases.
