Objective:Current theories highlight the role of the microbiome in the pathogenesis of psoriasis.Additionally,abnormal metabolism can alter disease processes in terms of occurrence,progression,and prognosis.Therefore,...Objective:Current theories highlight the role of the microbiome in the pathogenesis of psoriasis.Additionally,abnormal metabolism can alter disease processes in terms of occurrence,progression,and prognosis.Therefore,an integrative microbiome and metabolome analysis of the skin may aid in understanding the disease pathogenesis and identify therapeutic targets for psoriasis.Methods:We recruited 22 patients with psoriasis and 22 age-and sex-matched healthy controls.Skin swabs were collected from the participants’scalps.All samples underwent amplicon sequencing of the internal transcribed spacer 1 and V3V416S rRNA regions and metabolome analysis.For amplicon data,analysis of the alpha diversities,microbial community structures and principal coordinate analysis were performed.Differential metabolites and pathway enrichment were analyzed for metabolome data.Studentt test and Wilcoxon rank sum test were used for statistical analysis.Results:The psoriatic lesions were characterized by higher bacterial diversity,significantly higher abundances ofCorynebacterium(P<0.001)andStaphylococcus(P=0.012),and a lower abundance ofCutibacterium(P<0.001)compared with healthy controls.However,no significant alterations in the fungal diversity or fungal taxonomies were detected.Metabolome analysis revealed that prostaglandin-related metabolites,nucleotides,and cysteine-and methionine-related metabolites were significantly enriched in patients with psoriasis,and these metabolites were positively correlated with the disease-associated bacteriaStaphylococcus andCorynebacterium.Conclusions:We demonstrated significant alterations in the skin microbiome and metabolome in patients with psoriasis compared with healthy controls.展开更多
To the Editor:Persistent trigeminal artery(PTA)is one of the most common remaining fetal anastomoses.During embroyotic development,the link between the carotid and vertebral basilar circulation would normally regress....To the Editor:Persistent trigeminal artery(PTA)is one of the most common remaining fetal anastomoses.During embroyotic development,the link between the carotid and vertebral basilar circulation would normally regress.Carotid artery dissection(CAD)is a common cause of cerebral ischemia in young people,which can be caused by hyperhomocysteinemia(HHcy)possibly due to gene mutation.We report a case of posterior circulation ischemia caused by CAD.展开更多
Introduction Xanthogranuloma is a kind of rare,non-Langerhans cell histiocytosis that most commonly occurs in infancy or early childhood.Adult xanthogranuloma was first described by Gartmann and Tritsch in 1963,and th...Introduction Xanthogranuloma is a kind of rare,non-Langerhans cell histiocytosis that most commonly occurs in infancy or early childhood.Adult xanthogranuloma was first described by Gartmann and Tritsch in 1963,and there have been only approximately one hundred cases reported until now[1].Diagnosis of this disease might be complicated due to its unusual forms,and a group of dermatoses need to be differentiated.We here described a case of multiple adult xanthogranuloma (MAXG) in a young man.展开更多
基金supported by the National Natural Science Foundation of China(No.81903225)the Special Clinical Research for Young Scholar of Peking University First Hospital(No.2021CR20)。
文摘Objective:Current theories highlight the role of the microbiome in the pathogenesis of psoriasis.Additionally,abnormal metabolism can alter disease processes in terms of occurrence,progression,and prognosis.Therefore,an integrative microbiome and metabolome analysis of the skin may aid in understanding the disease pathogenesis and identify therapeutic targets for psoriasis.Methods:We recruited 22 patients with psoriasis and 22 age-and sex-matched healthy controls.Skin swabs were collected from the participants’scalps.All samples underwent amplicon sequencing of the internal transcribed spacer 1 and V3V416S rRNA regions and metabolome analysis.For amplicon data,analysis of the alpha diversities,microbial community structures and principal coordinate analysis were performed.Differential metabolites and pathway enrichment were analyzed for metabolome data.Studentt test and Wilcoxon rank sum test were used for statistical analysis.Results:The psoriatic lesions were characterized by higher bacterial diversity,significantly higher abundances ofCorynebacterium(P<0.001)andStaphylococcus(P=0.012),and a lower abundance ofCutibacterium(P<0.001)compared with healthy controls.However,no significant alterations in the fungal diversity or fungal taxonomies were detected.Metabolome analysis revealed that prostaglandin-related metabolites,nucleotides,and cysteine-and methionine-related metabolites were significantly enriched in patients with psoriasis,and these metabolites were positively correlated with the disease-associated bacteriaStaphylococcus andCorynebacterium.Conclusions:We demonstrated significant alterations in the skin microbiome and metabolome in patients with psoriasis compared with healthy controls.
基金supported by grants from the National Natural Science Foundation of China(No.81901198)Basic research of Suzhou Medical and health care(No.SYS201724).
文摘To the Editor:Persistent trigeminal artery(PTA)is one of the most common remaining fetal anastomoses.During embroyotic development,the link between the carotid and vertebral basilar circulation would normally regress.Carotid artery dissection(CAD)is a common cause of cerebral ischemia in young people,which can be caused by hyperhomocysteinemia(HHcy)possibly due to gene mutation.We report a case of posterior circulation ischemia caused by CAD.
文摘Introduction Xanthogranuloma is a kind of rare,non-Langerhans cell histiocytosis that most commonly occurs in infancy or early childhood.Adult xanthogranuloma was first described by Gartmann and Tritsch in 1963,and there have been only approximately one hundred cases reported until now[1].Diagnosis of this disease might be complicated due to its unusual forms,and a group of dermatoses need to be differentiated.We here described a case of multiple adult xanthogranuloma (MAXG) in a young man.
