Sequential Ir-catalyzed asymmetric allylation/2-aza-Cope rearrangement of arylidene aminomalonates with allylic carbonates was successfully developed,and a variety of enantioenriched homoallylic amine derivatives were...Sequential Ir-catalyzed asymmetric allylation/2-aza-Cope rearrangement of arylidene aminomalonates with allylic carbonates was successfully developed,and a variety of enantioenriched homoallylic amine derivatives were obtained in high yields with good chirality transfer and excellent E/Z-geometry control(up to 99%yield,96%ee).Compared with previous dual catalytic system established for this transformation,the current mono metal catalytic system provides a simpler and more practical protocol employing the readily available starting materials.展开更多
基金We are grateful for financial support from the National Natural Science Foundation of China(Grant Nos.21525207,21772147to C.J.W.)Natural Science Foundation of Jiangsu Province(Grant No.SKB2019041078 to X.Q.D.)+2 种基金Wuhan Morning Light Plan ofYouth Science and Technology(Grant No.2017050304010307 to X.Q.D.)Postdoctoral Innovative Talent Support Program of china(BX20190253 to C.s.).We thank Prof.Shu-Li You at SloC forgenerously providing(R,R)-THQ-PhosThe Program of Introducing Talents of Discipline to Universities of China(111 Project)is alsoappreciated.
文摘Sequential Ir-catalyzed asymmetric allylation/2-aza-Cope rearrangement of arylidene aminomalonates with allylic carbonates was successfully developed,and a variety of enantioenriched homoallylic amine derivatives were obtained in high yields with good chirality transfer and excellent E/Z-geometry control(up to 99%yield,96%ee).Compared with previous dual catalytic system established for this transformation,the current mono metal catalytic system provides a simpler and more practical protocol employing the readily available starting materials.
