Diabetes mellitus(DM)is a pressing global public health issue with a high incidence of morbidity and mortality due to its complications.Although there are many medicines available for the treatment of DM,long-term use...Diabetes mellitus(DM)is a pressing global public health issue with a high incidence of morbidity and mortality due to its complications.Although there are many medicines available for the treatment of DM,long-term use causes various adverse effects,such as diarrhea,vomiting,and nausea.Tea,owing to its richness of diverse bioactive components including tea polyphenols,tea polysaccharides,and alkaloids,has displayed promising antidiabetic properties.Screening antidiabetic bioactive compounds derived from teas is receiving increasing attention.Epidemiological and clinical investigations have demonstrated an inverse relationship between tea consumption and the incidence of DM.Both in vitro and in vivo experiments have substantiated the hypoglycemic effects of tea and its bioactive components through several possible mechanisms,including improvement of insulin resistance,inhibition of carbohydrates digestion and absorption(inhibitα-amylase andα-glucosidase activity),regulations of gut microbiota,inflammatory cytokines,and gene and protein expressions in the insulin signaling pathway,as well as amelioration of DM complications.This comprehensive review provides an up-to-date overview of the hypoglycemic properties associated with tea and its bioactive components.It also delves into their potential mechanisms,offering a theoretical foundation for further research into tea's antidiabetic properties and for the development of innovative antidiabetic functional products.展开更多
基金supported by the Zhejiang Province Natural Science Foundation(LR23C160002)the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2023-TRICAAS)the National Natural Science Foundation(32172630 and 31972467).
文摘Diabetes mellitus(DM)is a pressing global public health issue with a high incidence of morbidity and mortality due to its complications.Although there are many medicines available for the treatment of DM,long-term use causes various adverse effects,such as diarrhea,vomiting,and nausea.Tea,owing to its richness of diverse bioactive components including tea polyphenols,tea polysaccharides,and alkaloids,has displayed promising antidiabetic properties.Screening antidiabetic bioactive compounds derived from teas is receiving increasing attention.Epidemiological and clinical investigations have demonstrated an inverse relationship between tea consumption and the incidence of DM.Both in vitro and in vivo experiments have substantiated the hypoglycemic effects of tea and its bioactive components through several possible mechanisms,including improvement of insulin resistance,inhibition of carbohydrates digestion and absorption(inhibitα-amylase andα-glucosidase activity),regulations of gut microbiota,inflammatory cytokines,and gene and protein expressions in the insulin signaling pathway,as well as amelioration of DM complications.This comprehensive review provides an up-to-date overview of the hypoglycemic properties associated with tea and its bioactive components.It also delves into their potential mechanisms,offering a theoretical foundation for further research into tea's antidiabetic properties and for the development of innovative antidiabetic functional products.
