Research on neck dissection for oral squamous-cell carcinoma:a bibliometric analysis

Neck dissection for oral squamous-cell carcinoma(OSCC)is a clinically controversial issue and has therefore been the subject of abundant research.However,no one has performed a bibliometric study on this topic to date.The aim of this study was to assess the development of research on neck dissection for OSCC in terms of the historical evolution,current hotspots and future directions,particularly including research trends and frontiers from 2010 to 2019.Literature records related to research on neck dissection for OSCC were retrieved from the Web of Science Core Collection(WoSCC).CiteSpace was used as a tool to perform a bibliometric analysis of this topic.The survey included 2096 papers.“Otorhinolaryngology”was the most popular research area.The most active institutions and countries were Memorial Sloan Kettering Cancer Center and the USA,respectively.Shah J.P.was the most cited author.Among the six identified“core journals”,Head&Neck ranked first.The top three trending keywords were‘invasion’,‘upper aerodigestive’and‘negative neck’.‘D’Cruz AK(2015)’was the most cited and the strongest burst reference in the last decade.The study evaluated the effect on survival of elective versus therapeutic neck dissection in patients with lateralized early-stage OSCC.The depth of invasion and the management of N0 OSCC were research frontiers in this field.The present study provides a comprehensive bibliometric analysis of research on neck dissection for OSCC,which will assist investigators in exploring potential research directions.

A fluorescent probe operating under weak acidic conditions for the visualization of HOCl in solid tumors in vivo

Levels of reactive oxygen species(ROS)in cancer cells or in the tumor microenvironment differ noticeably from those in normal cells and cellular microenvironments because ROS play important roles in all aspects of tumor physiology.However,due to the lack of adequate tools,it is difficult to study the relationship between ROS,especially certain types of ROS(e.g.,HOCl),and cancer.We report herein an HOCl-specific fluorescent probe,FDOCl-20,containing a thiocarbamide group as a receptor,for the visualization of HOCl in solid tumors in vivo.This probe displays high selectivity and sensitivity to HOCl,and is appropriate for use in acidic conditions,including the tumor microenvironment.Using FDOCl-20 as a tool,we can visualize HOCl in solid tumors in vivo.Importantly,the fluorescent intensity of FDOCl-20 is proportional to tumor volume.Thus,FDOCl-20 is a useful tool to investigate the relationship between HOCl and the physiological processes of tumors.

北京近郊浅山地区的野生豹猫分布及环境影响因素

豹猫(Prionailurus bengalensis)是亚洲特有的小型野生猫科动物,当华北豹(Panthera pardus japonensis)等大型食肉类绝迹后,成为北京地区温带森林生态系统的主要捕食者,是衡量其所在生态网络完整性的底线。本研究自2022年10月至2023年6月在北京西部一段环绕北京城区的马蹄形山地(定名为“京西半月湾”),沿百望山–香山–西山–鹫峰–阳台山–妙峰山–凤凰岭–白虎涧一线共计开展16次徒步调查,总路线覆盖180 km,通过粪便样品的非损伤性采样和DNA分子遗传学物种鉴定,获得258个豹猫分布位点,确定了距离北京城区最近的浅山地区豹猫种群的广泛存在。本研究基于豹猫分布位点和选取的8个环境变量,构建了豹猫物种分布的集合模型。结果显示,在栖息地完整的情况下,豹猫的分布主要受人为干扰因素影响,其中到道路、不透水层等人类设施的距离对豹猫分布的解释率最高,为42.71%;其次是徒步强度,解释率为20.12%。人类设施作为一种较强程度的人为干扰,到此类生境的距离与豹猫的分布概率呈正相关,豹猫的适宜栖息地与城市环境中的人类设施保持1,000 m以上的缓冲距离。徒步强度作为相对温和的人为干扰与豹猫的分布呈负相关,但总体影响有限,豹猫对于适度的人类活动表现出一定的生态可塑性和耐受能力。本研究结果表明,在确保栖息地连续和食物链完整的前提下,将人类干扰控制在适度范围内,华北温带森林生态系统中以豹猫为代表的捕食者野生动物,即便在毗邻北京城区的近郊浅山地区也有续存的希望。

Seismic responses of an intensively constructed metro station-passageway-shaft structure system

Intensive construction methods offer benefits for metro station development,yet they present challenges for seismic design due to the spatially asymmetric configuration of passageway-shaft structures.In this study,a detailed numerical model of a station-passageway-shaft structure system built using intensive construction methods was developed and the deformation and damage modes under seismic loadings were analyzed.The results indicate that inconsistent deformation between the shaft and the station generates interaction through the connecting passageway,leading to damage near the opening of the station structure and both ends of the connecting passageway Damage is more severe under longitudinal excitation.Compared with the opening plan that spans four segments,the opening plan that spans five segments exacerbates the overall degree of damage to the structure system.Under transverse excitation,the presence of interior structures intensifies the damage to the station and connecting passageway,while with such internal structure in place the impact is relatively minor under longitudinal excitation.Reinforcement with steel segments near the station opening can appreciably attenuate the damage.In contrast,introducing flexible joints at both ends of the connecting passageway intensifies the damage.Hence,reinforcement using steel segments emerges as an optimal seismic mitigation strategy.

间充质干细胞调控肠脑轴治疗神经系统疾病的潜力

肠脑轴是指胃肠道与中枢神经系统之间存在的双向调控作用。近年来,肠脑轴成为了一个新的研究热点,大量研究探索肠道微生物群与神经系统疾病之间的关系。干细胞疗法是一种再生医学治疗方法,间充质干细胞(MSCs)在改善神经病理损伤和肠道炎症方面具有良好的疗效。本文阐述肠脑轴与几种常见神经系统疾病的关系以及肠脑轴在疾病进展中的关键作用,指出MSCs在调控肠脑轴治疗神经系统疾病方面的优势和潜力,并综述MSCs在调控肠脑轴治疗神经系统疾病中的应用进展,以期为神经系统疾病的治疗提供新思路。

Diagnosis of sewer pipe defects on image recognition of multi-features and support vector machine in a southern Chinese city

Closed circuit television(CCTV)systems are widely used to inspect sewer pipe conditions.During the diagnosis process,the manual diagnosis of defects is time consuming,labor intensive and error prone.To assist inspectors in diagnosing sewer pipe defects on CCTV inspection images,this paper presents an image recognition algorithm that applies features extraction and machine learning approaches.An algorithm of image recognition techniques,including Hu invariant moment,texture features,lateral Fourier transform and Daubechies(DBn)wavelet transform,was used to describe the features of defects,and support vector machines were used to classify sewer pipe defects.According to the inspection results,seven defects were defined;the diagnostic system was applied to a sewer pipe system in a southern city of China,and 28,760 m of sewer pipes were inspected.The results revealed that the classification accuracies of the different defects ranged from 51.6% to 99.3%.The overall accuracy reached 84.1%.The diagnosing accuracy depended on the number of the training samples,and four fitting curves were applied to fit the data.According to this paper,the logarithmic fitting curve presents the highest coefficient of determination of 0.882,and more than 200 images need to be used for training samples to guarantee the accuracy higher than 85%.

Design of High-Contrast Mechanochromic Materials Based on Aggregation-Induced Emissive Pyran Derivatives Guided by Polymorph Predictions

High-contrast mechanochromic(MC)materials are prominent candidates for sensor,security,and memory applications;however,the development of materials with a large luminescence change(Δλem>100 nm)under external stimuli is challenging.Considering that polymorphic molecules usually exhibit reversible mechanochromism,polymorph prediction is adopted for thefirst time to guide the design of high-contrastMC materials in this study.We designed and synthesized a series of donor–π–acceptor pyran derivatives bearing different electron donors and acceptors as model systems.The polymorph prediction indicated that 4-dicyanomethylene-2,6-distyryl-4H-pyran and 4H-pyran-4-one derivatives had the potential to crystallize in both monomer andπ-dimer aggregates,while barbituric acid-based compound tended to pack tightly in all aggregated states.The experimental results agreed well with the prediction that the derivatives potentially possessing both monomer andπ-dimer aggregate structures exhibit excellent MC behavior,whereas the fluorescence difference for the barbituric acid-based compounds is minimal.Moreover,a compound with an excellent fluorescence difference of three colors during reversible mechanochromism was chosen as the candidate for an optical recording material and security ink.This work proposes an effective method to guide the design of stimuli-responsive materials,which may open promising avenues for the development of high-contrast MC molecules.

SRSFs mediate the function of AR in the ovarian granulosa cells of patients with PCOS

Ovarian hyperandrogenism is one of the characteristics of polycystic ovary syndrome(PCOS)and androgen receptor(AR)in ovarian granulosa cells(GCs)functions as an important element to the accumulation of androgens.This study verified the existence of alternative splicing variant of AR(AR-SVs)in the GCs of PCOS patients and found that the function of AR decreased significantly in the presence of AR-SVs.And compared to the normal individuals,the expression of Serine/arginine-rich splicing factor 2(SRSF2)was higher and the expression of SRSF3 was lower in the GCs of patients with AR-SVs.More importantly,we found that the expression of SRSF2 was inhibited and that the expression of AR was decreased after the successful upregulation of miRNA-183,and testostrone(T)concentrations in the culture medium were increased.The results also showed that the expression of SRSF3 decreased when miRNA-124 was successfully upregulated,while the expression of AR significantly increased;however,the function of AR was also inhibited when T concentration in the culture medium was increased.This study has proved that SRSFs are regulated by corresponding miRNAs,and the altered expression of SRSFs interferenced the alternative splicing process of AR and ultimately decreased the function of AR,leading to the accumulation of androgens in the ovary.