Although midfoot injury,especilly Lisfranc sprain,is a relative rare traumatic pathology,if overlooked or treated incorrectly,the damage will develop into chronic Lisfranc injury,which is characterized by lifelong res...Although midfoot injury,especilly Lisfranc sprain,is a relative rare traumatic pathology,if overlooked or treated incorrectly,the damage will develop into chronic Lisfranc injury,which is characterized by lifelong residual symptoms.The differences in injury severity,healing rates,treatment plans,and patient adherence make pro-spective investigations of the pathogenesis of Lisfranc injury very dificult to conduct.The development of ananimal model that mimics the symptoms of humans with chronic Lisfranc injury has the potential to lessen thechallenges associated with prospective human research.Previous research has successfully used a mouse model to explore the biomechanics of the human ankle joint.However,it remains to be determined if the mouse model canmimic human midfoot functions based on their similarities in anatomical structure.In this study,the anatomicalstructure of the mouse and human midfoot were compared by CT scan.The animal image data were obtainedfrom 10 male C57BL/6J mice(20 feet)by micro-CT.The human data were obtained from six volunteers(six feet)by CT scanning.The three-dimensional skeletal structure of the midfoot was reconstr ucted,and the morphologicalparameters were measured by a plane projection method.There were no significant differences among thehindfoot adductus angle(mice:28.86±6.27°;human:25.45±2.70°),metatarsus aductus angle(mice:11.34±2.95°;human:11.48±3.97°),or the transverse arch angle(mice:111.77±4.70°;human:111.84±6.34°)between the mice and humans.The mice had a comparable Lisfranc joint complex architecture compared tohumans in both coronal and transverse planes.The lateral cuneiform was fused with the navicular bone in mice,which would provide better intrinsic stability than in humans.Future research is necessary to evaluate the mouse midfoot injury model and the similarities of their neuro-musculo-skletal systems with humans.展开更多
基金This work was supported by the National Key R&D Program of China(No.2018YFB1107000)the National Natural Science Foundation of China(11572211).
文摘Although midfoot injury,especilly Lisfranc sprain,is a relative rare traumatic pathology,if overlooked or treated incorrectly,the damage will develop into chronic Lisfranc injury,which is characterized by lifelong residual symptoms.The differences in injury severity,healing rates,treatment plans,and patient adherence make pro-spective investigations of the pathogenesis of Lisfranc injury very dificult to conduct.The development of ananimal model that mimics the symptoms of humans with chronic Lisfranc injury has the potential to lessen thechallenges associated with prospective human research.Previous research has successfully used a mouse model to explore the biomechanics of the human ankle joint.However,it remains to be determined if the mouse model canmimic human midfoot functions based on their similarities in anatomical structure.In this study,the anatomicalstructure of the mouse and human midfoot were compared by CT scan.The animal image data were obtainedfrom 10 male C57BL/6J mice(20 feet)by micro-CT.The human data were obtained from six volunteers(six feet)by CT scanning.The three-dimensional skeletal structure of the midfoot was reconstr ucted,and the morphologicalparameters were measured by a plane projection method.There were no significant differences among thehindfoot adductus angle(mice:28.86±6.27°;human:25.45±2.70°),metatarsus aductus angle(mice:11.34±2.95°;human:11.48±3.97°),or the transverse arch angle(mice:111.77±4.70°;human:111.84±6.34°)between the mice and humans.The mice had a comparable Lisfranc joint complex architecture compared tohumans in both coronal and transverse planes.The lateral cuneiform was fused with the navicular bone in mice,which would provide better intrinsic stability than in humans.Future research is necessary to evaluate the mouse midfoot injury model and the similarities of their neuro-musculo-skletal systems with humans.
