Ovarian cancer accounts for only 3% of all cancers in women, but it causes more deaths than any other gynecologic cancer. Treatment with chemotherapy and cytoreductive surgery shows a good response to the therapy. How...Ovarian cancer accounts for only 3% of all cancers in women, but it causes more deaths than any other gynecologic cancer. Treatment with chemotherapy and cytoreductive surgery shows a good response to the therapy. However, in a large proportion of the patients the tumor grows back within a few years. Cancer stem cells, that are less responsive to these treatments, are blamed for this recurrence of disease. Immune therapy either cellular or humoral is a novel concept to treat cancer. It is based on the notice that immune cells invade the tumor. However, the tumor invest heavily to escape from immune elimination by recruiting several immune suppressive mechanisms. These processes are normally in place to limit excessive immune activation and prevent autoimmune phenomena. Here, we discuss current knowledge about the immune(suppressive)status in ovarian cancer. Moreover, we discuss the immunological targets of ovarian cancer stem cells.展开更多
Neutrophils are considered as the privates of the innate immune system. They are born in the bone marrow, migrate to the tissues where they kill putative intruders. After their job they are quickly removed from the ba...Neutrophils are considered as the privates of the innate immune system. They are born in the bone marrow, migrate to the tissues where they kill putative intruders. After their job they are quickly removed from the battlefield by macrophages. This view of a predetermined pathway fitted nicely in their short lifespan of 5 h. However, recent studies indicated that their lifespan was in the order of several days. Recently, it became clear that neutrophils have functions beyond killing of pathogens. The reported half-life of 5 h is hardly compatible with those functions. Moreover, the organism actively invests in rescuing primed neutrophils from clearance by the body. It appears that their half-life is highly dependent on the method used to measure their life span. Here, we discuss the literature and show that neutrophils compartmentalize which could explain partially the differences reported for their lifespan. Moreover, the methodology to label neutrophils ex-vivo could have similar deteriorating effects on their lifespan as found for transfused red blood cells.展开更多
基金Supported by The Dutch government to the Netherlands Institute for Regenerative Medicine,No.FES0908
文摘Ovarian cancer accounts for only 3% of all cancers in women, but it causes more deaths than any other gynecologic cancer. Treatment with chemotherapy and cytoreductive surgery shows a good response to the therapy. However, in a large proportion of the patients the tumor grows back within a few years. Cancer stem cells, that are less responsive to these treatments, are blamed for this recurrence of disease. Immune therapy either cellular or humoral is a novel concept to treat cancer. It is based on the notice that immune cells invade the tumor. However, the tumor invest heavily to escape from immune elimination by recruiting several immune suppressive mechanisms. These processes are normally in place to limit excessive immune activation and prevent autoimmune phenomena. Here, we discuss current knowledge about the immune(suppressive)status in ovarian cancer. Moreover, we discuss the immunological targets of ovarian cancer stem cells.
文摘Neutrophils are considered as the privates of the innate immune system. They are born in the bone marrow, migrate to the tissues where they kill putative intruders. After their job they are quickly removed from the battlefield by macrophages. This view of a predetermined pathway fitted nicely in their short lifespan of 5 h. However, recent studies indicated that their lifespan was in the order of several days. Recently, it became clear that neutrophils have functions beyond killing of pathogens. The reported half-life of 5 h is hardly compatible with those functions. Moreover, the organism actively invests in rescuing primed neutrophils from clearance by the body. It appears that their half-life is highly dependent on the method used to measure their life span. Here, we discuss the literature and show that neutrophils compartmentalize which could explain partially the differences reported for their lifespan. Moreover, the methodology to label neutrophils ex-vivo could have similar deteriorating effects on their lifespan as found for transfused red blood cells.
