In order to balance electrochemical kinetics with loading level for achieving efficient energy storage with high areal capacity and good rate capability simultaneously for wearable electronics,herein,2 D meshlike vert...In order to balance electrochemical kinetics with loading level for achieving efficient energy storage with high areal capacity and good rate capability simultaneously for wearable electronics,herein,2 D meshlike vertical structures(NiCo_2 S_4@Ni(OH)_2) with a high mass loading of 2.17 mg cm^(-2) and combined merits of both 1 D nanowires and 2 D nanosheets are designed for fabricating flexible hybrid supercapacitors.Particularly,the seamlessly interconnected NiCo_2 S_4 core not only provides high capacity of 287.5 μAh cm^(-2) but also functions as conductive skeleton for fast electron transport;Ni(OH)_2 sheath occupying the voids in NiCo_2 S_4 meshes contributes extra capacity of 248.4 μAh cm^(-2);the holey features guarantee rapid ion diffusion along and across NiCO_2 S_4@Ni(OH)_2 meshes.The resultant flexible electrode exhibits a high areal capacity of 535.9 μAh cm^(-2)(246.9 mAh g^(-1)) at 3 mA cm^(-2) and outstanding rate performance with 84.7% retention at 30 mA cm^(-2),suggesting efficient utilization of both NiCo_2 S_4 and Ni(OH)_2 with specific capacities approaching to their theoretical values.The flexible solid-state hybrid device based on NiCo_2 S_4@Ni(OH)_2 cathode and Fe_2 O_3 anode delivers a high energy density of 315 μWh cm^(-2) at the power density of 2.14 mW cm^(-2) with excellent electrochemical cycling stability.展开更多
Two-dimensional(2D)magnets provide an ideal platform to explore new physical phenomena in fundamental magnetism and to realize the miniaturization of magnetic devices.The study on its domain structure evolution with t...Two-dimensional(2D)magnets provide an ideal platform to explore new physical phenomena in fundamental magnetism and to realize the miniaturization of magnetic devices.The study on its domain structure evolution with thickness is of great significance for better understanding the 2D magnetism.Here,we investigate the magnetization reversal and domain structure evolution in 2D ferromagnet Fe_(3)GeTe_(2)(FGT)with a thickness range of 11.2-112 nm.Three types of domain structures and their corresponding hysteresis loops can be obtained.The magnetic domain varies from a circular domain via a dendritic domain to a labyrinthian domain with increasing FGT thickness,which is accompanied by a transition from squared to slanted hysteresis loops with reduced coercive fields.These features can be ascribed to the total energy changes from exchange interaction-dominated to dipolar interaction-dominated with increasing FGT thickness.Our finding not only enriches the fundamental magnetism,but also paves a way towards spintronics based on 2D magnet.展开更多
Respiratory syncytial virus(RSV)is the major cause of bronchiolitis and pneumonia in young children and the elderly.There are currently no approved RSV-specific therapeutic small molecules available.Using high-through...Respiratory syncytial virus(RSV)is the major cause of bronchiolitis and pneumonia in young children and the elderly.There are currently no approved RSV-specific therapeutic small molecules available.Using high-throughput antiviral screening,we identified an oral drug,the prenylation inhibitor lonafarnib,which showed potent inhibition of the RSV fusion process.Lonafarnib exhibited antiviral activity against both the RSV A and B genotypes and showed low cytotoxicity in HEp-2 and human primary bronchial epithelial cells(HBEC).Time-of-addition and pseudovirus assays demonstrated that lonafarnib inhibits RSV entry,but has farnesyltransferase-independent antiviral efficacy.Cryo-electron microscopy revealed that lonafarnib binds to a triple-symmetric pocket within the central cavity of the RSV F metastable pre-fusion conformation.Mutants at the RSV F sites interacting with lonafarnib showed resistance to lonafarnib but remained fully sensitive to the neutralizing monoclonal antibody palivizumab.Furthermore,lonafarnib dose-dependently reduced the replication of RSV in BALB/c mice.Collectively,lonafarnib could be a potential fusion inhibitor for RSV infection.展开更多
Despite red phosphorous(P)-based anodes hold great promise for advanced lithium-ion batteries due to their high theoretical capacity, their practical application is hindered by poor electronic conductivity and drastic...Despite red phosphorous(P)-based anodes hold great promise for advanced lithium-ion batteries due to their high theoretical capacity, their practical application is hindered by poor electronic conductivity and drastic volume changes during charge-discharge processes. In order to tackle these issues, herein, a facile grinding method was developed to embed sub-micro-and nano-sized red P particles in N,P-codoped hierarchical porous carbon(NPHPC). Such a unique structure enables P@NPHPC long-cyclic stability(1120 mAh g^-1 after 100 cycles at 100 mA g^-1) and superior rate performance(248 mA h g^-1 at 6400 mA g^-1). It is believed that our method holds great potential in scalable synthesis of P@carbon composites for future practical applications.展开更多
Amorphous pseudocapacitive nanomaterials are highly desired in energy storage applications for their disordered crystal structures,fast electrochemical dynamics,and outstanding cyclic stability,yet hardly achievable u...Amorphous pseudocapacitive nanomaterials are highly desired in energy storage applications for their disordered crystal structures,fast electrochemical dynamics,and outstanding cyclic stability,yet hardly achievable using the state-of-the-art synthetic strategies.Herein,for the first time,high capacitive fiber electrodes embedded with nanosized amorphous molybdenum trioxide(A-MoO_(3)-x)featuring an average particle diameter of~20 nm and rich oxygen vacancies are obtained via a top-down method usingα-MoO_(3)bulk belts as the precursors.The Jahn-Teller distortion in MoO_(6)octahedra due to the doubly degenerate ground state of Mo5+,which can be continuously strengthened by oxygen vacancies,triggers the phase transformation ofα-MoO_(3)bulk belts(up to 30μm long and 500 nm wide).The optimized fibrous electrode exhibits among the highest volumetric performance with a specific capacitance(CV)of 921.5 F cm^(-3)under 0.3 A cm^(-3),endowing the fiber-based weaveable supercapacitor superior CV and EV(energy density)of 107.0 F cm^(-3)and 9.5 mWh cm^(-3),respectively,together with excellent cyclic stability,mechanical robustness,and rate capability.This work demonstrates a promising strategy for synthesizing nanosized amorphous materials in a scalable,cost-effective,and controllable manner.展开更多
基金supported by the National Natural Science Foundation of China (Nos. 21975123, 61704076)the Natural Science Basic Research Program of Shaanxi (No. 2020JM-092)+2 种基金the Natural Science Foundation of Jiangsu Province (No. BK20171018)the Six Talent Peaks Project in Jiangsu Province (No. XCL-024)the Fundamental Research Funds for the Central Universities。
文摘In order to balance electrochemical kinetics with loading level for achieving efficient energy storage with high areal capacity and good rate capability simultaneously for wearable electronics,herein,2 D meshlike vertical structures(NiCo_2 S_4@Ni(OH)_2) with a high mass loading of 2.17 mg cm^(-2) and combined merits of both 1 D nanowires and 2 D nanosheets are designed for fabricating flexible hybrid supercapacitors.Particularly,the seamlessly interconnected NiCo_2 S_4 core not only provides high capacity of 287.5 μAh cm^(-2) but also functions as conductive skeleton for fast electron transport;Ni(OH)_2 sheath occupying the voids in NiCo_2 S_4 meshes contributes extra capacity of 248.4 μAh cm^(-2);the holey features guarantee rapid ion diffusion along and across NiCO_2 S_4@Ni(OH)_2 meshes.The resultant flexible electrode exhibits a high areal capacity of 535.9 μAh cm^(-2)(246.9 mAh g^(-1)) at 3 mA cm^(-2) and outstanding rate performance with 84.7% retention at 30 mA cm^(-2),suggesting efficient utilization of both NiCo_2 S_4 and Ni(OH)_2 with specific capacities approaching to their theoretical values.The flexible solid-state hybrid device based on NiCo_2 S_4@Ni(OH)_2 cathode and Fe_2 O_3 anode delivers a high energy density of 315 μWh cm^(-2) at the power density of 2.14 mW cm^(-2) with excellent electrochemical cycling stability.
基金Project supported by the National Key R&D Program of China(Grant Nos.2017YFA0206202 and 2019YFA0308000)the National Natural Science Foundation of China(Grant Nos.51871130,62022089,and 11874405)the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.2019007)。
文摘Two-dimensional(2D)magnets provide an ideal platform to explore new physical phenomena in fundamental magnetism and to realize the miniaturization of magnetic devices.The study on its domain structure evolution with thickness is of great significance for better understanding the 2D magnetism.Here,we investigate the magnetization reversal and domain structure evolution in 2D ferromagnet Fe_(3)GeTe_(2)(FGT)with a thickness range of 11.2-112 nm.Three types of domain structures and their corresponding hysteresis loops can be obtained.The magnetic domain varies from a circular domain via a dendritic domain to a labyrinthian domain with increasing FGT thickness,which is accompanied by a transition from squared to slanted hysteresis loops with reduced coercive fields.These features can be ascribed to the total energy changes from exchange interaction-dominated to dipolar interaction-dominated with increasing FGT thickness.Our finding not only enriches the fundamental magnetism,but also paves a way towards spintronics based on 2D magnet.
基金supported by the Natural Science Foundation of Guangdong province(Grant no.2024A1515011589 to Q.Y.)the National Natural Science Foundation of China(Grant no.32000111 to Q.Y.,82170473 to J.S.)+3 种基金the Pearl River Talent Recruitment Program(Grant no.2019CX01Y422 to X.C.)the Guangzhou Laboratory(Grant no.SRPG22-002 to J.S.and X.C.,No.SRPG22-011 to W.P.and Q.Y.)the Basic and Applied Basic Research Projects of Guangzhou Basic Research Program(2023A04J0161 to Q.Y.,2021QN020451 to J.S.)the Young Elite Scientists Sponsorship Program by CAST(Grant no.2023QNRC001 to F.L.).
文摘Respiratory syncytial virus(RSV)is the major cause of bronchiolitis and pneumonia in young children and the elderly.There are currently no approved RSV-specific therapeutic small molecules available.Using high-throughput antiviral screening,we identified an oral drug,the prenylation inhibitor lonafarnib,which showed potent inhibition of the RSV fusion process.Lonafarnib exhibited antiviral activity against both the RSV A and B genotypes and showed low cytotoxicity in HEp-2 and human primary bronchial epithelial cells(HBEC).Time-of-addition and pseudovirus assays demonstrated that lonafarnib inhibits RSV entry,but has farnesyltransferase-independent antiviral efficacy.Cryo-electron microscopy revealed that lonafarnib binds to a triple-symmetric pocket within the central cavity of the RSV F metastable pre-fusion conformation.Mutants at the RSV F sites interacting with lonafarnib showed resistance to lonafarnib but remained fully sensitive to the neutralizing monoclonal antibody palivizumab.Furthermore,lonafarnib dose-dependently reduced the replication of RSV in BALB/c mice.Collectively,lonafarnib could be a potential fusion inhibitor for RSV infection.
基金supported by the National Key Research and Development Program of China (2021YFB3601301,2022YFA1405100,and 2022YFA1403601)the National Natural Science Foundation of China (52225106,12241404,12150011,and 12174405)supported by High Magnetic Field Laboratory of Anhui Province。
基金supported by the National Key Basic Research Program of China (2015CB932200)the National Natural Science Foundation of China (61704076)+2 种基金the Natural Science Foundation of Jiangsu Province (BK20171018)Jiangsu Specially-Appointed Professor Program (54935012)the support from the Fundamental Research Funds for the Central Universities (31020180QD094)
文摘Despite red phosphorous(P)-based anodes hold great promise for advanced lithium-ion batteries due to their high theoretical capacity, their practical application is hindered by poor electronic conductivity and drastic volume changes during charge-discharge processes. In order to tackle these issues, herein, a facile grinding method was developed to embed sub-micro-and nano-sized red P particles in N,P-codoped hierarchical porous carbon(NPHPC). Such a unique structure enables P@NPHPC long-cyclic stability(1120 mAh g^-1 after 100 cycles at 100 mA g^-1) and superior rate performance(248 mA h g^-1 at 6400 mA g^-1). It is believed that our method holds great potential in scalable synthesis of P@carbon composites for future practical applications.
基金supported by the National Natural Science Foundation of China(No.21975123)the Natural Science Basic Research Program of Shaanxi(No.2020JM-092)+2 种基金Six Talent Peaks Project in Jiangsu Province(No.XCL-024)Cultivation Program for The Excellent Doctoral Dissertation of Nanjing Tech University,Postgraduate Research&Practice Innovation Program of Jiangsu Province(Nos.SJCX20_0401 and KYCX20_0997)the Fundamental Research Funds for the Central Universities.
文摘Amorphous pseudocapacitive nanomaterials are highly desired in energy storage applications for their disordered crystal structures,fast electrochemical dynamics,and outstanding cyclic stability,yet hardly achievable using the state-of-the-art synthetic strategies.Herein,for the first time,high capacitive fiber electrodes embedded with nanosized amorphous molybdenum trioxide(A-MoO_(3)-x)featuring an average particle diameter of~20 nm and rich oxygen vacancies are obtained via a top-down method usingα-MoO_(3)bulk belts as the precursors.The Jahn-Teller distortion in MoO_(6)octahedra due to the doubly degenerate ground state of Mo5+,which can be continuously strengthened by oxygen vacancies,triggers the phase transformation ofα-MoO_(3)bulk belts(up to 30μm long and 500 nm wide).The optimized fibrous electrode exhibits among the highest volumetric performance with a specific capacitance(CV)of 921.5 F cm^(-3)under 0.3 A cm^(-3),endowing the fiber-based weaveable supercapacitor superior CV and EV(energy density)of 107.0 F cm^(-3)and 9.5 mWh cm^(-3),respectively,together with excellent cyclic stability,mechanical robustness,and rate capability.This work demonstrates a promising strategy for synthesizing nanosized amorphous materials in a scalable,cost-effective,and controllable manner.
