期刊文献+
共找到3篇文章
< 1 >
每页显示 20 50 100
AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination 被引量:2
1
作者 Chunxia Jiang Wanqing Yang +6 位作者 Zhihong Fan Peng Teng ruyi mei Junlin Yang Aifen Yang Mengsheng Qiu Xiaofeng Zhao 《Neuroscience Bulletin》 SCIE CAS CSCD 2018年第3期527-533,共7页
Oligodendrocytes(OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK(... Oligodendrocytes(OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK(apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination. We therefore studied its role in OL differentiation. The results showed that AATYK knockdown inhibited OL differentiation and the expression of myelin genes in vitro. Moreover, AATYKdeficiency maintained the proliferation status of OLs but did not affect their survival. Thus, AATYK is essential for the differentiation of OLs. 展开更多
关键词 AATYK DIFFERENTIATION OLIGODENDROCYTES
原文传递
TAPP1 Represses the Differentiation of Oligodendrocyte and its Deficiency Accelerates Myelin Regeneration after Demyelinating Injuries 被引量:1
2
作者 ruyi mei Jiaying Fu +5 位作者 Chunxia Jiang Junlin Yang Kang Zheng Aifen Yang Mengsheng Qiu Xiaofeng Zhao 《Neuroscience Bulletin》 SCIE CAS CSCD 2021年第3期385-388,共4页
Dear Editor,Myelin,the lipid-rich insulation that supports the integrity of axons,enables rapid conduction of nerve impulses and information flow to distant brain areas[1].Oligodendrocytes(OLs)are glial cells that mye... Dear Editor,Myelin,the lipid-rich insulation that supports the integrity of axons,enables rapid conduction of nerve impulses and information flow to distant brain areas[1].Oligodendrocytes(OLs)are glial cells that myelinate axons with specialized lipid membrane extensions[2].OL progenitor cells(OPCs)arise from neural stem cells[3],and undergo proliferation before terminal differentiation and eventual myelination.Impairment at any stage of OL development can affect myelin formation. 展开更多
关键词 INSULATION conduction enable
原文传递
TAPP1 inhibits the differentiation of oligodendrocyte precursor cells via suppressing the Mek/Erk pathway 被引量:1
3
作者 Yidan Chen ruyi mei +5 位作者 Peng Teng Aifen Yang Xuemei Hu Zunyi Zhang Mengsheng Qiu Xiaofeng Zhao 《Neuroscience Bulletin》 SCIE CAS CSCD 2015年第5期517-526,共10页
Oligodendrocytes(OLs) are glial cells that form myelin sheaths around axons in the central nervous system(CNS).Loss of the myelin sheath in demyelinating and neurodegenerative diseases can lead to severe impairmen... Oligodendrocytes(OLs) are glial cells that form myelin sheaths around axons in the central nervous system(CNS).Loss of the myelin sheath in demyelinating and neurodegenerative diseases can lead to severe impairment of movement.Understanding the extracellular signals and intracellular factors that regulate OL differentiation and myelination during development can help to develop novel strategies for enhancing myelin repair in neurological disorders.Here,we report that TAPP1 was selectively expressed in differentiating OL precursor cells(OPCs).TAPP1 knockdown promoted OL differentiation and myelin gene expression in culture.Conversely,over-expression of TAPP1 in immature OPCs suppressed their differentiation.Moreover,TAPP1 inhibition in OPCs altered the expression of Erk1/2 but not AKT.Taken together,our results identify TAPP1 as an important negative regulator of OPC differentiation through the Mek/Erk signaling pathway. 展开更多
关键词 TAPP1 differentiation oligodendrocyte spinal cord
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部