Coffee has long been recognized as having hepatoprotective properties,however,the extent of any beneficial effect is still being elucidated.Coffee appears to reducerisk of hepatocellular carcinoma,reduce advancement o...Coffee has long been recognized as having hepatoprotective properties,however,the extent of any beneficial effect is still being elucidated.Coffee appears to reducerisk of hepatocellular carcinoma,reduce advancement of fibrotic disease in a variety of chronic liver diseases,and perhaps reduce ability of hepatitis C virus to replicate.This review aims to catalog the evidence for coffee as universally beneficial across a spectrum of chronic liver diseases,as well as spotlight opportunities for future investigation into coffee and liver disease.展开更多
BACKGROUND Music seems to be beneficial in multiple clinical areas.Colonoscopy is a stressful event for patients,especially with conscious sedation.Music during colonoscopy has been evaluated in multiple randomized co...BACKGROUND Music seems to be beneficial in multiple clinical areas.Colonoscopy is a stressful event for patients,especially with conscious sedation.Music during colonoscopy has been evaluated in multiple randomized controlled trials(RCTs)with varied results.Even meta-analyses on the subject over the years have yielded inconsistent conclusions.Therefore,we conducted an up-to-date meta-analysis regarding music during colonoscopy.AIM To assess the effects of music played during colonoscopy on patients’perspectives and sedation requirements.METHODS Multiple large databases were aggressively searched(November 2018).RCTs comparing music to without music during colonoscopy on adult patients were included.Pooled estimates were calculated for sedative medication doses,total procedure time,and patients’experience,willingness to repeat procedure,and pain scores using odds ratio(OR)and mean difference(MD)with random effects model.RESULTS Eleven studies(n=988)were included.Music during colonoscopy showed a statistically significant reduction in procedure times(MD:-2.3 min;95%CI:-4.13 to-0.47;P=0.01)and patients’pain(MD:-1.26;95%CI:-2.28 to-0.24;P=0.02)while improving patients’experience(MD:-1.11;95%CI:-1.7 to-0.53;P<0.01)as compared to no music.No statistically significant differences were observed between music and no music during colonoscopy for midazolam(MD:-0.4 mg;95%CI:-0.9 to 0.09;P=0.11),meperidine(MD:-3.06 mg;95%CI:-10.79 to 4.67;P=0.44),or patients’willingness to repeat the colonoscopy(OR:3.89;95%CI:0.76 to 19.97;P=0.1).CONCLUSION Music appears to improve overall patient experience while reducing procedure times and patient pain.Therefore,music,being a non-invasive intervention,should be strongly considered during colonoscopy.展开更多
Human hepatocyte transplantation is undergoing study as a bridge,or even alternative,to orthotopic liver transplantation(OLT).This technique has undergone multiple developments over the past thirty years in terms of m...Human hepatocyte transplantation is undergoing study as a bridge,or even alternative,to orthotopic liver transplantation(OLT).This technique has undergone multiple developments over the past thirty years in terms of mode of delivery,source and preparation of cell cultures,monitoring of graft function,and use of immunosuppression.Further refinements and improvements in these techniques will likely allow improved graft survival and function,granting patients higher yield from this technique and potentially significantly delaying need for OLT.展开更多
文摘Coffee has long been recognized as having hepatoprotective properties,however,the extent of any beneficial effect is still being elucidated.Coffee appears to reducerisk of hepatocellular carcinoma,reduce advancement of fibrotic disease in a variety of chronic liver diseases,and perhaps reduce ability of hepatitis C virus to replicate.This review aims to catalog the evidence for coffee as universally beneficial across a spectrum of chronic liver diseases,as well as spotlight opportunities for future investigation into coffee and liver disease.
文摘BACKGROUND Music seems to be beneficial in multiple clinical areas.Colonoscopy is a stressful event for patients,especially with conscious sedation.Music during colonoscopy has been evaluated in multiple randomized controlled trials(RCTs)with varied results.Even meta-analyses on the subject over the years have yielded inconsistent conclusions.Therefore,we conducted an up-to-date meta-analysis regarding music during colonoscopy.AIM To assess the effects of music played during colonoscopy on patients’perspectives and sedation requirements.METHODS Multiple large databases were aggressively searched(November 2018).RCTs comparing music to without music during colonoscopy on adult patients were included.Pooled estimates were calculated for sedative medication doses,total procedure time,and patients’experience,willingness to repeat procedure,and pain scores using odds ratio(OR)and mean difference(MD)with random effects model.RESULTS Eleven studies(n=988)were included.Music during colonoscopy showed a statistically significant reduction in procedure times(MD:-2.3 min;95%CI:-4.13 to-0.47;P=0.01)and patients’pain(MD:-1.26;95%CI:-2.28 to-0.24;P=0.02)while improving patients’experience(MD:-1.11;95%CI:-1.7 to-0.53;P<0.01)as compared to no music.No statistically significant differences were observed between music and no music during colonoscopy for midazolam(MD:-0.4 mg;95%CI:-0.9 to 0.09;P=0.11),meperidine(MD:-3.06 mg;95%CI:-10.79 to 4.67;P=0.44),or patients’willingness to repeat the colonoscopy(OR:3.89;95%CI:0.76 to 19.97;P=0.1).CONCLUSION Music appears to improve overall patient experience while reducing procedure times and patient pain.Therefore,music,being a non-invasive intervention,should be strongly considered during colonoscopy.
文摘Human hepatocyte transplantation is undergoing study as a bridge,or even alternative,to orthotopic liver transplantation(OLT).This technique has undergone multiple developments over the past thirty years in terms of mode of delivery,source and preparation of cell cultures,monitoring of graft function,and use of immunosuppression.Further refinements and improvements in these techniques will likely allow improved graft survival and function,granting patients higher yield from this technique and potentially significantly delaying need for OLT.
