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Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings 被引量:7
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作者 Elisabet A.Rank ryan sentosa +12 位作者 Danielle J.Harper Matthias Salas Anna Gaugutz Dana Seyringer Stefan Nevlacsil Alejandro Maese-Novo Moritz Eggeling Paul Muellner Rainer Hainberger Martin Sagmeister Jochen Kraft Rainer ALeitgeb Wolfgang Drexler 《Light(Science & Applications)》 SCIE EI CAS CSCD 2021年第1期71-85,共15页
In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip.The diffraction gratings used in spectral-domain optical coherence tomogr... In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip.The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating.Two arrayed waveguide grating designs with 256 channels were tested,which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements.Design 1 supports a bandwidth of 22nm,with which a sensitivity of up to 91 dB(830μW) and an axial resolution of 10.7 pm was measured.Design 2 supports a bandwidth of 48 nm,with which a sensitivity of 90 dB(480μW) and an axial resolution of 6.5μm was measured.The silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process,which allows their monolithic co-integration on top of an optoelectronic silicon chip.As a benchmark for chip-based optical coherence tomography,tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip gratings.The similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system. 展开更多
关键词 WAVEGUIDE arrayed optical
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