Microglia are brain-resident immune cells that contribute to the maintenance of brain homeostasis.In the epileptic brain, microglia show various activation phenotypes depending on the stage of epileptogenesis.Therefor...Microglia are brain-resident immune cells that contribute to the maintenance of brain homeostasis.In the epileptic brain, microglia show various activation phenotypes depending on the stage of epileptogenesis.Therefore, it remains unclear whether microglial activation acts in a pro-epileptic or anti-epileptic manner.In mesial temporal lobe epilepsy, one of the most common form of epilepsies, microglia exhibit at least two distinct morphologies, amoeboid shape and ramified shape.Amoeboid microglia are often found in sclerotic area, whereas ramified microglia are mainly found in non-sclerotic area;however, it remains unclear whether these structurally distinct microglia share separate roles in the epileptic brain.Here, we review the roles of the two distinct microglial phenotypes, focusing on their pro-and anti-epileptic roles in terms of inflammatory response, regulation of neurogenesis and microglia-neuron interaction.展开更多
Microglia are brain-resident immune cells that use their ramified processes to survey the brain parenchyma.They maintain brain homeostasis by mediating immune responses through cytokine release,phagocytosing pathogens...Microglia are brain-resident immune cells that use their ramified processes to survey the brain parenchyma.They maintain brain homeostasis by mediating immune responses through cytokine release,phagocytosing pathogens and protein aggregation(Salter et al.,2017).Furthermore,in both healthy and disease states,microglia interacting with neurons regulate synaptic formation,elimination and plasticity(Salter et al.,2017).It is thought that these functions may be altered by environmental stimuli such as lifestyle,stress,infection and air pollution,the effects of which may result in brain dysfunction and the development of neurodegenerative diseases(Branchi et al.,2014;Hanamsagar et al.,2017).展开更多
基金supported in part by a Grant-in-Aid for Scientific Research (B)(17H03988 to RK) from JSPS and JST PRESTO (JPMJPR18H4 to RK)。
文摘Microglia are brain-resident immune cells that contribute to the maintenance of brain homeostasis.In the epileptic brain, microglia show various activation phenotypes depending on the stage of epileptogenesis.Therefore, it remains unclear whether microglial activation acts in a pro-epileptic or anti-epileptic manner.In mesial temporal lobe epilepsy, one of the most common form of epilepsies, microglia exhibit at least two distinct morphologies, amoeboid shape and ramified shape.Amoeboid microglia are often found in sclerotic area, whereas ramified microglia are mainly found in non-sclerotic area;however, it remains unclear whether these structurally distinct microglia share separate roles in the epileptic brain.Here, we review the roles of the two distinct microglial phenotypes, focusing on their pro-and anti-epileptic roles in terms of inflammatory response, regulation of neurogenesis and microglia-neuron interaction.
基金This work was supported in part by a Grant-in-Aid for Scientific Research(B)(17H03988,to RK)from JSPS and JST PRESTO(JPMJPR18H4,to RK).
文摘Microglia are brain-resident immune cells that use their ramified processes to survey the brain parenchyma.They maintain brain homeostasis by mediating immune responses through cytokine release,phagocytosing pathogens and protein aggregation(Salter et al.,2017).Furthermore,in both healthy and disease states,microglia interacting with neurons regulate synaptic formation,elimination and plasticity(Salter et al.,2017).It is thought that these functions may be altered by environmental stimuli such as lifestyle,stress,infection and air pollution,the effects of which may result in brain dysfunction and the development of neurodegenerative diseases(Branchi et al.,2014;Hanamsagar et al.,2017).
