In the past decade carbon ion beam has attracted growing interest in cancer therapy. This could be attributed to the excellent characteristics of the carbon ion beam in physical and biological selectivities such as do...In the past decade carbon ion beam has attracted growing interest in cancer therapy. This could be attributed to the excellent characteristics of the carbon ion beam in physical and biological selectivities such as dose localization in the Bragg peak and high relative biological effectiveness over the peak. To enhance the efficacy of heavy ion beams in treating tumors, we have even proposed a novel idea usingβ-delayed particle decay beams such as 9C, 8B and 8Li. These ra'dioactive ion beams (RIB) isotropically emit low展开更多
A β-delayed particle decay 9C-ion beam as a type of double irradiation source is expected to enhance the curative effect when applying it to heavy-ion cancer therapy. It has been proved in our previous
A β-delayed particle decay beam like 9C has been recognized as a double irradiation source, i.e. the external beam radiation itself and the delayed low-energy particles emitted internally. A radioactive 9C-ion beam, ...A β-delayed particle decay beam like 9C has been recognized as a double irradiation source, i.e. the external beam radiation itself and the delayed low-energy particles emitted internally. A radioactive 9C-ion beam, therefore, is considered to be very useful in cancer radiation therapy. To explore the potential importance of radioactive 9C-ion beams in cancer therapy, radiobiological experiments using a 9C beam supplied by the secondary beam line (SBL) at the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan were carried out.展开更多
It is generally believed that there is no dose-rate sparing effect for mammalian cells exposed to high-LET heavy ion beams. To clarify this ambiguity, human salivary gland (HSG) cells were irradiated with carbon ion b...It is generally believed that there is no dose-rate sparing effect for mammalian cells exposed to high-LET heavy ion beams. To clarify this ambiguity, human salivary gland (HSG) cells were irradiated with carbon ion beams supplied by the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan at a low dose rate of 0.展开更多
Natural killer (NK) cells are innate immune effectors that produce various immunoregulatory cytokines. Recent studies have shown that NK cells are involved in the initiation of autoimmunity. In this study, we determin...Natural killer (NK) cells are innate immune effectors that produce various immunoregulatory cytokines. Recent studies have shown that NK cells are involved in the initiation of autoimmunity. In this study, we determined abnormalities of NK cells in systemic sclerosis (SSc), an autoimmune connective tissue disease, by assessing the frequency and absolute number, activation marker expression, cytokine production, and killing activity. The frequency and absolute number of NK cells increased in diffuse cutaneous SSc (dcSSc), whereas they were normal in limited cutaneous SSc (IcSSc). NK cells from both dcSSc and IcSSc patients exhibited activated phenotypes characterized by up-regulated CD16 and CD69 expression and downregulated CD62L expression. Interferon (IFN)-γ production by non-stimulated NK cells from both dcSSc and IcSSc patientswas increased compared to the normal control, whereas on stimulation, a reduced amount of IFN-γ was produced. Interleukin (IL)- 5 and IL- 10 production by non- stimulated NK cells and IL- 6 production by stimulated NK cells were augmented in dcSSc patients, but not in IcSSc patients. Despite the augmented cytokine production by non-stimulated NK cells, natural cytotoxicity activity and granzyme B secretion was reduced in NK cells from dcSSc and IcSSc patients. These results suggested that altered NK cell function contributes to immunological abnormalities in SSc.展开更多
Nuclear structure of proton-rich unstable nucleus 28P has been studied by measuring its g-factor for the first time. The g-factor of 28P (Iπ =3+, T1/2=270.3 ms) was measured by means of β-NMR technique combined with...Nuclear structure of proton-rich unstable nucleus 28P has been studied by measuring its g-factor for the first time. The g-factor of 28P (Iπ =3+, T1/2=270.3 ms) was measured by means of β-NMR technique combined with the new polarization technique for charge exchange reaction product in the intermediate energy heavy ion collisions. The obtained g-factor of g=0.1028(27) is very much quenched from the Schmidt value, but is well reproduced by the shell model (+0.102). In connection with the magnetic moment of the mirror partner and the β-ray transition probability, the orbital angular momenta and intrinsic spins of protons and neutrons have been determined as lp =0.43(29), ln =1.85(29), Sp)=0.28(4), and Sn =0.44(4).展开更多
文摘In the past decade carbon ion beam has attracted growing interest in cancer therapy. This could be attributed to the excellent characteristics of the carbon ion beam in physical and biological selectivities such as dose localization in the Bragg peak and high relative biological effectiveness over the peak. To enhance the efficacy of heavy ion beams in treating tumors, we have even proposed a novel idea usingβ-delayed particle decay beams such as 9C, 8B and 8Li. These ra'dioactive ion beams (RIB) isotropically emit low
文摘A β-delayed particle decay 9C-ion beam as a type of double irradiation source is expected to enhance the curative effect when applying it to heavy-ion cancer therapy. It has been proved in our previous
文摘A β-delayed particle decay beam like 9C has been recognized as a double irradiation source, i.e. the external beam radiation itself and the delayed low-energy particles emitted internally. A radioactive 9C-ion beam, therefore, is considered to be very useful in cancer radiation therapy. To explore the potential importance of radioactive 9C-ion beams in cancer therapy, radiobiological experiments using a 9C beam supplied by the secondary beam line (SBL) at the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan were carried out.
文摘It is generally believed that there is no dose-rate sparing effect for mammalian cells exposed to high-LET heavy ion beams. To clarify this ambiguity, human salivary gland (HSG) cells were irradiated with carbon ion beams supplied by the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan at a low dose rate of 0.
文摘Natural killer (NK) cells are innate immune effectors that produce various immunoregulatory cytokines. Recent studies have shown that NK cells are involved in the initiation of autoimmunity. In this study, we determined abnormalities of NK cells in systemic sclerosis (SSc), an autoimmune connective tissue disease, by assessing the frequency and absolute number, activation marker expression, cytokine production, and killing activity. The frequency and absolute number of NK cells increased in diffuse cutaneous SSc (dcSSc), whereas they were normal in limited cutaneous SSc (IcSSc). NK cells from both dcSSc and IcSSc patients exhibited activated phenotypes characterized by up-regulated CD16 and CD69 expression and downregulated CD62L expression. Interferon (IFN)-γ production by non-stimulated NK cells from both dcSSc and IcSSc patientswas increased compared to the normal control, whereas on stimulation, a reduced amount of IFN-γ was produced. Interleukin (IL)- 5 and IL- 10 production by non- stimulated NK cells and IL- 6 production by stimulated NK cells were augmented in dcSSc patients, but not in IcSSc patients. Despite the augmented cytokine production by non-stimulated NK cells, natural cytotoxicity activity and granzyme B secretion was reduced in NK cells from dcSSc and IcSSc patients. These results suggested that altered NK cell function contributes to immunological abnormalities in SSc.
基金Supported by National Natural Science Foundation of China (10435010, 10505032)
文摘Nuclear structure of proton-rich unstable nucleus 28P has been studied by measuring its g-factor for the first time. The g-factor of 28P (Iπ =3+, T1/2=270.3 ms) was measured by means of β-NMR technique combined with the new polarization technique for charge exchange reaction product in the intermediate energy heavy ion collisions. The obtained g-factor of g=0.1028(27) is very much quenched from the Schmidt value, but is well reproduced by the shell model (+0.102). In connection with the magnetic moment of the mirror partner and the β-ray transition probability, the orbital angular momenta and intrinsic spins of protons and neutrons have been determined as lp =0.43(29), ln =1.85(29), Sp)=0.28(4), and Sn =0.44(4).
