Kinesin is a microtubule-associated motor protein which can respond to the external electric field due to its polarity.Using a molecular dynamics simulation method, the effect of such a field on the affinity of kinesi...Kinesin is a microtubule-associated motor protein which can respond to the external electric field due to its polarity.Using a molecular dynamics simulation method, the effect of such a field on the affinity of kinesin to the α β-tubulin is investigated in this study. To consider kinesin affinity, the system is exposed to an electric field of 0.03 V/nm with frequency values of 1, 2,..., 9, and 10 GHz. It is found that the applied electric field can change kinesin affinity to the microtubule.These changes could perturb the normal operation of kinesin, such as the processive motility of kinesin on the microtubule.展开更多
文摘Kinesin is a microtubule-associated motor protein which can respond to the external electric field due to its polarity.Using a molecular dynamics simulation method, the effect of such a field on the affinity of kinesin to the α β-tubulin is investigated in this study. To consider kinesin affinity, the system is exposed to an electric field of 0.03 V/nm with frequency values of 1, 2,..., 9, and 10 GHz. It is found that the applied electric field can change kinesin affinity to the microtubule.These changes could perturb the normal operation of kinesin, such as the processive motility of kinesin on the microtubule.
