A subacute toxicity study of a potent tetanus toxoid (250 Lf) was carried out in guinea pigs.The toxoid was injected subcutaneously at the nape of the neck at dose levels of 1.0, 1.5.and 2.0 ml in Groups Ⅱ. Ⅲ. and ...A subacute toxicity study of a potent tetanus toxoid (250 Lf) was carried out in guinea pigs.The toxoid was injected subcutaneously at the nape of the neck at dose levels of 1.0, 1.5.and 2.0 ml in Groups Ⅱ. Ⅲ. and Ⅳ, respectively.In the controls (Group Ⅰ) 2.0 ml of aluminum phosphate suspension was given in each injection.Periodic evaluations of body weight, food/water intake, general observable behavior, hematology.and blood chemistry in toxoid-injected guinea pigs were similar to those in control guinea pigs.Thus, the toxoid did not cause any side effects up to four times the dose proposed for humans.1990 Academic Press, Inc.展开更多
Tolnidamine (50 mg / kg body wt. / alternate day for 90 days; oral) was investigated for its contraceptive efficacy, causes of irreversibility, and side-effects by assessment of seminal characteristics and biochemistr...Tolnidamine (50 mg / kg body wt. / alternate day for 90 days; oral) was investigated for its contraceptive efficacy, causes of irreversibility, and side-effects by assessment of seminal characteristics and biochemistry, morphometry, libido and clinical investigations in adult male langur monkeys ( Presbytis entellus entellus Dufresne) . Semen weight, volume, colour, pH and libido remained unaltered. Sperm motility, vitality and morphology were impaired with the advancement of the treatment. Increased number of immature germ cells was also noted. Sperm density reduced to severe oligospermia following 45 days of treatment and remained low during recovery period. A marked reversible reduction in seminal GPC and magnesium levels was notieed, while other biachemical parameters remained unchanged. Irreversible changes in various morphometric data of Sertoli cells and spermatogonia were observed. Circulatory levels of testosterone fluctuated within pretreatment range. A significant but reversible elevation in serum creatinine was evident. The possible causes for irreversibility are the ever lasting alterations in the morphometry of Sertoli ceils and spermatogonia.展开更多
We study the static and dynamical behavior of the contact line between two fluids and a solid plate by means of the Lattice Boltzmann method(LBM).The different fluid phases and their contact with the plate are simulat...We study the static and dynamical behavior of the contact line between two fluids and a solid plate by means of the Lattice Boltzmann method(LBM).The different fluid phases and their contact with the plate are simulated by means of standard Shan-Chen models.We investigate different regimes and compare the multicomponent vs.the multiphase LBM models near the contact line.A static interface profile is attained with the multiphase model just by balancing the hydrostatic pressure(due to gravity)with a pressure jump at the bottom.In order to study the same problem with the multicomponent case we propose and validate an idea of a body force acting only on one of the two fluid components.In order to reproduce results matching an infinite bath,boundary conditions at the bath side play a key role.We quantitatively compare open and wall boundary conditions and study their influence on the shape of the meniscus against static and lubrication theory solution.展开更多
文摘A subacute toxicity study of a potent tetanus toxoid (250 Lf) was carried out in guinea pigs.The toxoid was injected subcutaneously at the nape of the neck at dose levels of 1.0, 1.5.and 2.0 ml in Groups Ⅱ. Ⅲ. and Ⅳ, respectively.In the controls (Group Ⅰ) 2.0 ml of aluminum phosphate suspension was given in each injection.Periodic evaluations of body weight, food/water intake, general observable behavior, hematology.and blood chemistry in toxoid-injected guinea pigs were similar to those in control guinea pigs.Thus, the toxoid did not cause any side effects up to four times the dose proposed for humans.1990 Academic Press, Inc.
文摘Tolnidamine (50 mg / kg body wt. / alternate day for 90 days; oral) was investigated for its contraceptive efficacy, causes of irreversibility, and side-effects by assessment of seminal characteristics and biochemistry, morphometry, libido and clinical investigations in adult male langur monkeys ( Presbytis entellus entellus Dufresne) . Semen weight, volume, colour, pH and libido remained unaltered. Sperm motility, vitality and morphology were impaired with the advancement of the treatment. Increased number of immature germ cells was also noted. Sperm density reduced to severe oligospermia following 45 days of treatment and remained low during recovery period. A marked reversible reduction in seminal GPC and magnesium levels was notieed, while other biachemical parameters remained unchanged. Irreversible changes in various morphometric data of Sertoli cells and spermatogonia were observed. Circulatory levels of testosterone fluctuated within pretreatment range. A significant but reversible elevation in serum creatinine was evident. The possible causes for irreversibility are the ever lasting alterations in the morphometry of Sertoli ceils and spermatogonia.
基金funded by FOM(Foundation for Fundamental Research on Matter).
文摘We study the static and dynamical behavior of the contact line between two fluids and a solid plate by means of the Lattice Boltzmann method(LBM).The different fluid phases and their contact with the plate are simulated by means of standard Shan-Chen models.We investigate different regimes and compare the multicomponent vs.the multiphase LBM models near the contact line.A static interface profile is attained with the multiphase model just by balancing the hydrostatic pressure(due to gravity)with a pressure jump at the bottom.In order to study the same problem with the multicomponent case we propose and validate an idea of a body force acting only on one of the two fluid components.In order to reproduce results matching an infinite bath,boundary conditions at the bath side play a key role.We quantitatively compare open and wall boundary conditions and study their influence on the shape of the meniscus against static and lubrication theory solution.
