With the recent advancement in nanotechnology,nanoparticles(NPs)offer an ample variety of smart functions than conventional materials in various aspects.As compared to larger particles,NPs possess unique characteristi...With the recent advancement in nanotechnology,nanoparticles(NPs)offer an ample variety of smart functions than conventional materials in various aspects.As compared to larger particles,NPs possess unique characteristics and excellent abilities,such as low toxicity,chemical stability,surface functionality,and biocompatibility.These advantageous properties allow them to be widely utilized in many applications,including biomedical applications,energy applications,IT applications,and industrial applications.In order to fulfill the increasing demands of NP applications,existing NP synthesis methods need to be improved based on the requirements of different applications to further their usage.A comprehensive understanding of the relationships between synthesis parameters and properties of NPs can help us better fine-tune them with designed properties and minimal toxicity.This review paper will discuss the commonly used synthesis methods of functionalized NPs,as well as future directions and challenges to develop various synthesis methods further.展开更多
Microglial cells are non-neuronal cells which serve as the first line of defence against various injuries and insults in the central nervous system(CNS).They act as sentinels that constantly patrol the surrounding par...Microglial cells are non-neuronal cells which serve as the first line of defence against various injuries and insults in the central nervous system(CNS).They act as sentinels that constantly patrol the surrounding parenchyma through their ramified processes in the CNS.In response to any pathological insult,microglia become activated,undergo proliferation,migrate to the site of injury or infection,and release chemokines and cytokines followed by the phagocytosis of dead cells and debris.展开更多
文摘With the recent advancement in nanotechnology,nanoparticles(NPs)offer an ample variety of smart functions than conventional materials in various aspects.As compared to larger particles,NPs possess unique characteristics and excellent abilities,such as low toxicity,chemical stability,surface functionality,and biocompatibility.These advantageous properties allow them to be widely utilized in many applications,including biomedical applications,energy applications,IT applications,and industrial applications.In order to fulfill the increasing demands of NP applications,existing NP synthesis methods need to be improved based on the requirements of different applications to further their usage.A comprehensive understanding of the relationships between synthesis parameters and properties of NPs can help us better fine-tune them with designed properties and minimal toxicity.This review paper will discuss the commonly used synthesis methods of functionalized NPs,as well as future directions and challenges to develop various synthesis methods further.
基金This work was supported by the NUS Strategic Research Grant(Memory Networks in Rodent and Primate)DPRT/944/09/14(R185-000-271-646)(to STD)Ministry of Education(Tier 2)grant(R181-000-186-112)(to STD).
文摘Microglial cells are non-neuronal cells which serve as the first line of defence against various injuries and insults in the central nervous system(CNS).They act as sentinels that constantly patrol the surrounding parenchyma through their ramified processes in the CNS.In response to any pathological insult,microglia become activated,undergo proliferation,migrate to the site of injury or infection,and release chemokines and cytokines followed by the phagocytosis of dead cells and debris.
